Normal Bone Marrow

Babyn, Paul; Ranson, Marilyn; McCarville, Mary E.

doi:10.1016/s1064-9689(21)00233-6

Cited by 51 publications

(1 citation statement)

References 72 publications

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“…With aging, there is progressive conversion, and in adults, normal bone marrow is characterized by fatty conversion and low hematopoietic cellularity, which on MRI gives the typical appearance of relatively high signal intensity on T1-weighted images (compared with skeletal muscle and disks) and low signal on STIR or fat-suppressed T2 images (compared with skeletal muscle). 3…”

Section: General Considerations About Imaging In the Oncologic Patientmentioning

confidence: 99%

Effects of Radiation Therapy and Chemotherapy on the Musculoskeletal System

Gómez

Aparisi

Morganti

et al. 2022

Semin Musculoskelet Radiol

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The effects of radiation and chemotherapy on the musculoskeletal (MSK) system are diverse, and interpretation may be challenging. The different lines of treatment have effects on diseased and normal marrow, and they may lead to complications that must be differentiated from recurrence or progression. This review analyzes the changes induced by radiotherapy and chemotherapy in the MSK system in the adult and pediatric population, and the expected associated imaging findings. Treatments are often combined, so the effects may blend. Awareness of the spectrum of changes, complications, and their imaging appearances is paramount for the correct diagnosis. The assessment of body composition during and after treatment allows potential interventions to implement long-term outcomes and personalize treatments. Imaging techniques such as computed tomography or magnetic resonance imaging provide information on body composition that can be incorporated into clinical pathways. We also address future perspectives in posttreatment assessment.

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Section: General Considerations About Imaging In the Oncologic Patientmentioning

confidence: 99%

Effects of Radiation Therapy and Chemotherapy on the Musculoskeletal System

Gómez

Aparisi

Morganti

et al. 2022

Semin Musculoskelet Radiol

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Bones of the Lower Limb

Haffner

Conklin

2016

Bergman's Comprehensive Encyclopedia of Human Anatomic Variation

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Comparison of qualitative and quantitative analyses of age‐related changes in clivus bone marrow on MR imaging

et al. 2003

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Magnetic resonance (MR) imaging is capable of detecting a wide spectrum of diseases involving clivus bone marrow. To evaluate any pathology in this region, the normal MR signal intensity patterns according to age should be known. Assessment of clivus bone marrow is usually and more efficiently made visually (qualitatively) on routine MR imaging. To compare the qualitative and quantitative analyses of age-related changes in clivus bone marrow on MR imaging, midsagittal T1-weighted MR images of the clivus bone marrow were prospectively evaluated in 201 subjects. MR signal intensity patterns of clivus bone marrow were qualitatively graded from I to III according to the proportions of low and high signal intensity areas within the clivus (Grade I: predominantly hypointense, Grade III: predominantly hyperintense). Signal intensity measurements were also made from the clivus, pons, and the cerebrospinal fluid within the fourth ventricle. Grade I pattern was observed in 92% of the subjects in the first decade, whereas Grade III pattern was not seen in this decade; Grade I pattern was absent in all but one of the subjects over the age of 50. Mean values of clivus/pons and clivus/CSF signal intensity measurements gradually increased with age in both males and females. Comparison of these ratios in each gender showed statistically significant higher values for males (P < 0.05). Comparison of the qualitative and quantitative results showed that calculated mean values of intensity ratios for each grade were different from each other; however, there was an overlap of the ranges of signal intensity ratios for Grades II and III. Visual evaluation of the clivus bone marrow MR signal is validated with the quantitative assessment results. Statistically significant higher intensity ratios in males may reflect a difference between gender in the bone mineral content under the influence of sex hormones.

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Normal Bone Marrow

Cited by 51 publications

References 72 publications

Effects of Radiation Therapy and Chemotherapy on the Musculoskeletal System

Effects of Radiation Therapy and Chemotherapy on the Musculoskeletal System

Bones of the Lower Limb

Comparison of qualitative and quantitative analyses of age‐related changes in clivus bone marrow on MR imaging

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