“…Radiotherapy can be considered a “double-edged sword.” Beyond its cytotoxic effects on malignant cells, radiation is a well-known mutagen. When used therapeutically for many inoperable thoracic tumors, lower doses at the periphery of the irradiation zone render these regions at the highest risk for malignancy because these cells undergo DNA damage without cell death [5] . A uniform mechanism for radiation-induced carcinogenesis remains poorly understood, and each tissue type has its own sensitivity to radiation [6] .…”