Normal body mass index (BMI) can rule out metabolic syndrome

Abstract

The aim of the study was to assess whether body mass index (BMI) can be used as a simple and reliable survey test for metabolic syndrome.The study is an observational cohort study among patients who visited the Rambam Periodic Examinations Institute (RPEI). We analyzed the correlation between obesity indices and presence of metabolic syndrome. We identified the ideal value of BMI for identification of patients at risk for metabolic syndrome. We also described the correlation between different BMI values and its negative predictive value (NPV) for metabolic syndrome.During the study years, 23,993 patients visited the RPEI, and 12.5% of them fulfilled the criteria for metabolic syndrome. Women with metabolic syndrome had higher proportion of obesity, when compared with men (89.9% vs 52.6%; P < .0001). Normal BMI had very high NPV to rule out metabolic syndrome among men and women (98% and 96%, respectively). Using receiver-operating characteristic curve, we found BMI 27 to be the ideal value for identification of metabolic syndrome for the entire cohort (area under the curve [AUC] 0.767, 95% confidence interval [CI] 0.758–0.775, P < .0001), for men (AUC 0.726, 95% CI 0.715–0.738, P < .0001), and for women (AUC 0.843, 95% CI 0.831–0.855, P < .0001). BMI below 30 provided NPV of 91.1% to rule out metabolic syndrome.The BMI as single survey measurement of obesity offers high NPV for metabolic syndrome and can be used by physician and patients for this purpose.

Anthropometric indices and cut-off points in the diagnosis of metabolic disorders

“…An optimal cut-off point for the BMI for the identification of metabolic disorders is 27.2 kg/m 2 for both sexes. Similar values for MetS were obtained in a study conducted in Israel (27 kg/m 2 ) [42]. Compared with our results, the BMI cut-off values for individual metabolic disorders obtained in studies conducted in Jordan, were slightly lower in men (26.2-27.2 kg/m 2 ), but higher in women (27.2-30.0 kg/m 2 ) [33].…”

Sex-based differences in and risk factors for metabolic syndrome in adults aged 40 years and above in Northeast China: Results from the cross-sectional China national stroke screening survey

“…These findings also suggest that weight gain in men (BMI ≥26 kg/m 2 ) increases the risk of MS more substantially than it does in women; this positive association has also been reported in a study of Turkish adults. 28 An Israeli cohort study claimed that a normal BMI had a high negative predictive value in both men (98%) and women (96%) with respect to MS. 29 The inverse association was found between hip circumference and metabolic risk factors in Tehranian women. 30 Further, weak predictive ability was found for hip circumference.…”

Clinical implication of metabolic syndrome in nonobese patients with antineutrophil cytoplasmic antibody-associated vasculitis

“…Whereas, in our study, BMI of AAV patients was signi cantly lower than that of controls, which exhibited an opposite tendency of the prevalence of MetS. Although BMI is not one of the components of the 2005 NCEP-ATP-III criteria, BMI is another independent index for determining obesity and considered one of the risks for MetS [6,27]. This inverse tendency suggests that another unique risk factor exists in AAV patients other than the conventional risk factors for MetS in normal people and it was assumed as the in ammatory burden of AAV.…”