Normal biochemistry values in baboons (Papio c. cinocephalus)

Cano, M.; Desco, M.; García‐Barreno, Pedro

doi:10.1016/0305-0491(90)90208-b

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…The liver was 600 g at the time of transplantation and regenerated to a computed tomographic (CT) scan estimated size of 1074 g after one week and 1555 g by day 24. Although he was released from intensive care after one month, he developed several infections (table 11) that necessitated treatment with nephrotoxic antibodies. The most disabling of these was mixed CMV and candida oesophagi tis and duodenitis, which were suspected to be the cause of recurrent gastrointestinal haemorrhages from days 27-39 and which required 14 units of transfused blood.…”

Section: Clinical Coursementioning

confidence: 99%

Baboon-to-human liver transplantation

Vine¹,

Kier²,

Starzl³

et al. 1993

The Lancet

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Section: Clinical Coursementioning

confidence: 99%

Baboon-to-human liver transplantation

Vine¹,

Kier²,

Starzl³

et al. 1993

The Lancet

View full text Add to dashboard Cite

Baboon-to-human liver transplantation

et al. 1993

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Our ability to control both the cellular and humoral components of xenograft rejection in laboratory experiments, together with an organ shortage that has placed limits on clinical transplantation services, prompted us to undertake a liver transplantation from a baboon to a 35-year-old man with B virus-associated chronic active hepatitis and human immunodeficiency virus infection.Liver replacement was performed according to conventional surgical techniques. Immunosuppression was with the FK 506-prednisone-prostaglandin regimen used routinely for hepatic allotransplantation, to which a daily non-myelotoxic dose of cyclophosphamide was added. During 70 days of survival, there was little evidence of hepatic rejection by biochemical monitoring or histopathological examination. Products of hepatic synthesis, including clotting factors, became those of the baboon liver with no obvious adverse effects. Death followed a cerebral and subarachnoid haemorrhage that was caused by an angioinvasive aspergillus infection. However, the underlying cause of death was widespread biliary sludge that formed in the biliary tree despite a seemingly satisfactory choledochojejunostomy. During life and in necropsy samples, there was evidence of the chimerism that we believe is integral to the acceptance of both xenografts and allografts.Our experience has shown the feasibility of controlling the rejection of the baboon liver xenograft in a human recipient. The biliary stasis that was the beginning of lethal infectious complications may be correctable by modifications of surgical technique. In further trials, the error of overimmunosuppression should be avoidable.

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Normal biochemistry values in baboons (Papio c. cinocephalus)

Cited by 2 publications

References 3 publications

Baboon-to-human liver transplantation

Baboon-to-human liver transplantation

Baboon-to-human liver transplantation

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