Baboon-to-human liver transplantation

Vine, William; Kier, Amm; Starzl, T. E.; Warty, VijayS.

doi:10.1016/0140-6736(93)93183-2

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Two years later, the first chimpanzee-to-human liver transplantation was carried out by Starzl, but the patient never recovered [ 75 ]. In 1992, a patient survived for 70 d after transplantation with a baboon liver and immunosuppression [ 80 , 81 ]. While these studies raise feasibility concerns, other hurdles for NHP xenotransplantation are risk of the organ infection, time, the expense of NHP breeding and the limited availability of NHP organs [ 82 ].…”

Section: Xenotransplantationmentioning

confidence: 99%

Genome editing in large animals: current status and future prospects

Zhao

Lai

et al. 2019

National Science Review

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Large animals (non-human primates, livestock and dogs) are playing important roles in biomedical research, and large livestock animals serve as important sources of meat and milk. The recently developed programmable DNA nucleases have revolutionized the generation of gene-modified large animals that are used for biological and biomedical research. In this review, we briefly introduce the recent advances in nuclease-meditated gene editing tools, and we outline these editing tools’ applications in human disease modeling, regenerative medicine and agriculture. Additionally, we provide perspectives regarding the challenges and prospects of the new genome editing technology.

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Section: Xenotransplantationmentioning

confidence: 99%

Genome editing in large animals: current status and future prospects

Zhao

Lai

et al. 2019

National Science Review

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“…The ability of SHFV genome RNA to replicate in cells from other species including humans suggests that it has the potential to cross the species barrier. The use of baboon organs for human transplantation could facilitate the selection of mutants that could infect humans (Levy, 2000; Vine and Kier, 1993). Over expression of Myxoma virus M013 was previously shown to antagonize proinflammatory cytokine production induced through both the inflammasome and the NF-κB pathway (Rahman and McFadden, 2011; Rahman et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Insertion position as well as the inserted TRS and gene sequences differentially affect the retention of foreign gene expression by simian hemorrhagic fever virus (SHFV)

et al. 2018

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Recombinant SHFV infectious cDNA clones expressing a foreign gene from an additional sg mRNA were constructed. Two 3′ genomic region sites, between ORF4′ and ORF2b and between ORF4 and ORF5, were utilized for insertion of the myxoma M013 gene with a C-terminal V5 tag followed by one of the three inserted transcription regulatory sequences (TRS), TRS2′, TRS4′ or TRS7. M013 insertion at the ORF4′/ORF2b site but not the ORF4/ORF5 site generated progeny virus but only recombinant viruses with an inserted TRS2′ retained the entire M013 gene through passage four. Insertion of an auto-fluorescent protein gene, iLOV, with an inserted TRS2′ at the ORF4′/ORF2b site generated viable progeny virus and iLOV expression was maintained through passage eight. Although regulation of SHFV subgenomic RNA synthesis is complex, the ORF4′/ORF2b site, which is located between the two sets of minor structural proteins, is able to tolerate foreign gene insertion.

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“…The liver/body weight ratio is a fundamental parameter for the correct and complete liver mass restoring [ 65 ]. In this respect, it has been seen that transplanting from a donor animal with a smaller liver to the receiver, entails a re-organisation that allows the transplanted liver to reach the weight of the recipient [ 66 ]. Several sources suggest that the proper functioning of the hepatostat is provided by mammalian target of rapamycin (mTOR), demonstrating that, post PH, the rapamycin induced inhibition of mTOR is able to block DNA replication [ 67 , 68 ].…”

Section: Liver Regeneration Step By Stepmentioning

confidence: 99%

Liver Regeneration and Immunity: A Tale to Tell

Di-Iacovo

Pieroni

Piobbico

et al. 2023

IJMS

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The physiological importance of the liver is demonstrated by its unique and essential ability to regenerate following extensive injuries affecting its function. By regenerating, the liver reacts to hepatic damage and thus enables homeostasis to be restored. The aim of this review is to add new findings that integrate the regenerative pathway to the current knowledge. An optimal regeneration is achieved through the integration of two main pathways: IL-6/JAK/STAT3, which promotes hepatocyte proliferation, and PI3K/PDK1/Akt, which in turn enhances cell growth. Proliferation and cell growth are events that must be balanced during the three phases of the regenerative process: initiation, proliferation and termination. Achieving the correct liver/body weight ratio is ensured by several pathways as extracellular matrix signalling, apoptosis through caspase-3 activation, and molecules including transforming growth factor-beta, and cyclic adenosine monophosphate. The actors involved in the regenerative process are numerous and many of them are also pivotal players in both the immune and non-immune inflammatory process, that is observed in the early stages of hepatic regeneration. Balance of Th17/Treg is important in liver inflammatory process outcomes. Knowledge of liver regeneration will allow a more detailed characterisation of the molecular mechanisms that are crucial in the interplay between proliferation and inflammation.

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Baboon-to-human liver transplantation

Cited by 4 publications

References 6 publications

Genome editing in large animals: current status and future prospects

Genome editing in large animals: current status and future prospects

Insertion position as well as the inserted TRS and gene sequences differentially affect the retention of foreign gene expression by simian hemorrhagic fever virus (SHFV)

Liver Regeneration and Immunity: A Tale to Tell

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