Normal Arterial Blood Pressure in the Nephrectomized Fetal Lamb

Nd, Binder; Df, Anderson; Dm, Potter; Thornburg, Kent L.; Jj, Faber

doi:10.1159/000241575

Cited by 3 publications

(7 citation statements)

References 7 publications

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“…22 Methodological differences in ECV measurement do not explain the reduction in BV per kg after nephrectomy. A reduction in BV was also observed by Scroop et al 23 Consistent with these findings, during the course of a study by Binder et al, 6 BV rose in intact foetuses (P < 0.05 by paired t-test on their data) but not in nephrectomized foetuses. Interestingly, in the present study, although BV per kg was lower after nephrectomy, haematocrit was unaltered.…”

Section: Body Fluid Compartmentssupporting

confidence: 69%

“…Many workers have reported at least one of these blood gas changes after foetal nephrectomy. 5,6,8,18 The poorer blood gas status after nephrectomy may have been due to several factors. First, the nephrectomized foetuses had lower HR and, therefore, possibly lower cardiac outputs and reduced placental blood flows compared with intact foetuses.…”

Section: Arterial Blood Gasesmentioning

confidence: 99%

“…Previously, nephrectomized foetuses have been used to study the autonomy of the foetal renin-angiotensin system (RAS) 1,2 and the role of the foetal kidney in growth, 3 lung development, 4 regulation of arterial pressure [5][6][7][8] and erythropoietin production. 9 It is well recognized that the foetal kidneys are vital for maintaining extrafoetal fluids (amniotic and allantoic fluids), 10 but it is not known how important the kidneys are for the maintenance of the normal volume and composition of the foetal body fluids.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, because adult animals display an exaggerated pressor response to AngII after nephrectomy, 12 the arterial pressor responses to bolus injections of AngII were measured before and after the 3 day infusions. Although a number of groups have studied basal blood pressure in nephrectomized foetuses, 5,6,8 vascular sensitivity to AngII has not been previously examined in nephrectomized foetuses. pedicle was ligated three times with linen sutures before the kidney was removed.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Bilateral Nephrectomy and Angiotensin Ii Replacement on Body Fluids in Foetal Sheep

Gibson

Lumbers

1999

Clin Exp Pharma Physio

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1. To determine the importance of the kidneys in maintaining the normal volume and composition of foetal body fluids, measurements were made in 11 chronically catheterized foetuses (123-136 days) that had been bilaterally nephrectomized at least 5 days previously and compared with 10 intact foetuses (121-133 days). 2. The nephrectomized foetuses had reduced extracellular (ECV), blood, plasma and interstitial volumes per kg foetal weight (P < 0.005), reduced plasma chloride levels (P < 0.001) and were acidaemic, hypoxaemic and hypercapnaemic (P < 0.05) compared with intact foetuses. They also had reduced lung liquid production (P < 0.05) and reduced lung liquid sodium and osmolality levels (P < 0.05). Their arterial pressure was more variable between foetuses (P < 0.005) and was directly related to ECV/kg (P = 0.013). 3. To determine which of these changes were due to absence of the foetal renin-angiotensin system, seven chronically catheterized nephrectomized foetal sheep (124-132 days) were infused with replacement doses of angiotensin (Ang)II (1.5 micrograms/kg per h) for 3 days. Six nephrectomized foetuses were infused with 0.15 mol/L saline. 4. The AngII infusion was non-pressor. It prevented the fall in ECV that occurred in the control group (P < 0.05) and foetal plasma chloride concentration rose (P < 0.05). Blood gas status and lung liquid production rate did not change, but lung liquid sodium concentration fell (P < 0.05) and potassium concentration rose (P < 0.05). 5. Bolus injections of AngII (0.3-5 micrograms) were given to assess vascular sensitivity to AngII. This was not altered by either nephrectomy or AngII replacement. 6. It is concluded that the foetal kidneys are important for the maintenance of the normal volume and composition of foetal body fluids. Angiotensin II, perhaps because it promotes fluid transfer across the placenta, helps maintain foetal ECV and plasma chloride levels.

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Section: Body Fluid Compartmentssupporting

confidence: 69%

Section: Arterial Blood Gasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Bilateral Nephrectomy and Angiotensin Ii Replacement on Body Fluids in Foetal Sheep

Gibson

Lumbers

1999

Clin Exp Pharma Physio

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“…of mean, mmHg, Mott, 1981). In contrast, Binder, Anderson, Potter, Thornburg & Faber (1982) reported no difference between mean pressures in nephrectomized (41-5 + 3 S.E. of mean, mmHg) and intact (43-9+1-4 S.E.…”

mentioning

confidence: 91%

Proceedings of the Physiological Society, 20‐21 July 1984, Cambridge Meeting: Communications

1984

The Journal of Physiology

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It has long been known that the haemoglobin of neonates, juveniles and pregnant women is more susceptible to methaemoglobinization by sodium nitrite than that of adults. In 1981 we (Metcalf, Metcalf & Tarburton) reported to the Society that this reaction takes place in two phases, a lag and a log phase, and that both are longer in haemoglobin obtained from adults.The recently acquired reputation of alkyl nitrites (amyl and butyl) as aphrodisiacs has led to an increase in their inhalation by children and adults resulting in a number of deaths. We therefore decided to investigate the reaction of this class of compounds with haemoglobin in vitro.Two ml samples of cord blood and adult blood were collected by venepuncture in EDTA vacutainers. After washing, the red cells were haemolysed in distilled water, and the haemoglobin concentration adjusted to a consistent value in the cuvette of a recording spectrophotometer. This enabled the methaemoglobinization reaction, when a measured amount of nitrite was mixed with the haemoglobin, to be followed.In contrast to the reaction of sodium nitrite with haemoglobin, the reaction commenced immediately, i.e. there was no lag phase. However, the difference in sensitivity between the haemoglobin of cord blood and that of adult blood was even more pronounced than in the reaction with sodium nitrite. The reaction rate was proportional to the concentration of both amyl nitrite and haemoglobin; it was reduced by the addition of superoxide dismutase, but was unaffected by the addition of catalase to the reaction mixture.Whilst further work is clearly needed, it would seem advisable to avoid exposing pregnant women, neonates and probably juveniles to organic nitrites.

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Research on the history of salto skill development on the balance beam

Nakasone

2021

Japan Journal of Physical Education, Health and Sport Sciences

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Normal Arterial Blood Pressure in the Nephrectomized Fetal Lamb

Cited by 3 publications

References 7 publications

Effects of Bilateral Nephrectomy and Angiotensin Ii Replacement on Body Fluids in Foetal Sheep

Effects of Bilateral Nephrectomy and Angiotensin Ii Replacement on Body Fluids in Foetal Sheep

Proceedings of the Physiological Society, 20‐21 July 1984, Cambridge Meeting: Communications

Research on the history of salto skill development on the balance beam

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