Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis

Abe, Osamu; Aoki, Shigeki; Hayashi, Naoto; Yamada, Hideaki; Kunimatsu, Akira; Mori, Hiromu; Yoshikawa, Tsuneo; Okubo, Toshiyuki; Ohtomo, Kuni

doi:10.1016/s0197-4580(01)00318-9

Cited by 396 publications

(263 citation statements)

References 17 publications

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“…We observed diffuse age-related reductions in FA in frontal, parietal, occipital, and temporal WM, consistent with previous results (Abe et al 2002;Madden et al shows scatter plots of the correlations between mean FA and SES in each WM region for each group (seniors=filled circles; young adults=open circles). Note: To render FA-SES regression plots more interpretable, participants' SES values on the ISP were converted such that higher scores now reflected higher levels of SES (by subtracting each participant's score from 100) (2013) 35:2045-20562004; O'Sullivan et al 2001;Pfefferbaum et al 2000).…”

Section: Discussionsupporting

confidence: 91%

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Johnson

Kim

Gold

2012

AGE

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Socioeconomic status (SES) is an important reserve variable which has been shown to benefit the aging brain's macrostructure. However, it remains unknown whether SES affects age-related changes in the brain's white matter (WM) microstructure. Here, we used diffusion tensor imaging to explore the relationship between SES and three components of the diffusion tensor [fractional anisotropy (FA), axial diffusivity, and radial diffusivity (DR)]. Participants were 40 (16 male) cognitively normal young adults (mean age=33.3 years, SD=4.27) and 44 (19 male) cognitively normal community dwelling seniors (mean age=66.2 years, SD= 7.5). Age-related FA declines were observed across a large portion of the WM skeleton. However, seniors with high SES showed lower age-related WM integrity declines in three frontal tracts: the right anterior corona radiata and bilateral portions of WM underlying the superior frontal gyri (SFG-WM). Positive SES-FA correlations were primarily driven by negative DR-SES correlations, suggesting that SES may buffer age-related declines in myelin. The functional significance of high SES in these frontal tracts was demonstrated through positive correlations with working memory performance. Possible mechanisms through which SES may attenuate the effects of age on frontal WM integrity are discussed.

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Section: Discussionsupporting

confidence: 91%

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Johnson

Kim

Gold

2012

AGE

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“…This is similar to findings reporting an increase in mean diffusivity within other regions of the brain in normal aging (Abe et al 2002;Moseley 2002). IQ was not statistically significantly correlated with any MRI measures for either group.…”

Section: Correlation Of Mr Measures Of the Fornix And The Hippocampussupporting

confidence: 91%

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients

Kuroki

Kubicki

Nestor

et al. 2006

Biological Psychiatry

138

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Background-The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia.

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“…This interpretation is in agreement with findings of reduced corpus callosum size (Doraiswamy et al, 1991;Sullivan et al, 2001;Weis et al, 1991) and reduced callosal functioning in ageing. Several studies using diffusion MRI confirmed disruption of white matter tract and commissural connectivity in normal ageing (Abe et al, 2002;Nusbaum, Tang, Buchsbaum, Wei, & Atlas, 2001;Pfefferbaum et al, 2000;Sullivan et al, 2001) which might lead to reduced callosal function and interhemispheric communication. Age-related increased asymmetry is also suggested in studies involving other modalities like visual and motor modalities that found increased interhemispheric transfer time with increasing age (Bellis & Wilber, 2001;Jeeves & Moes, 1996;Reuter-Lorenz & Stanczak, 2000).…”

Section: Increased Ear Asymmetry In Localisation Errors In Elderlymentioning

confidence: 99%

Age Effects in Identifying and Localising Dichotic Stimuli: A Corpus Callosum Deficit

Gootjes

Strien

Bouma

2004

Journal of Clinical and Experimental Neuropsychology

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In the present study, dichotic listening performance of 31 older adults was compared with performance of 25 younger adults under free and focussed attention conditions. In addition to an age-related general decrease in performance, we observed in the focussed attention condition increased asymmetry in the elderly group: the decrease of recall performance was stronger for the left ear (LE) than for the right ear (RE), while the increase of localisation errors was greater for the RE than for the LE. Identifying and localising digits appear to be different processes mediated predominantly by the left and right hemisphere, respectively. Since agerelated reduced performance is strongest for the ear ipsilateral to the hemisphere dominant to that particular function, these findings may be ascribed to decline of corpus callosum functioning resulting in decreased interhemispheric interaction rather than to a selective decline of right hemisphere functions.Age-related decline in cognitive functioning in healthy older adults appears to be restricted to tasks that demand more effortful processing. On tasks demanding automatic processing, elderly adults perform similarly to younger adults. Agerelated decline most probably is a consequence of deficits in selective attention needed during effortful processing (Kinsbourne, 1980). In the present research, we studied age differences in dichotic listening performance. The dichotic listening test (DLT) is an excellent tool for examining age-related cognitive decline since it involves different degrees of attentional and memory processing.The DLT is a non-invasive procedure to study the lateralisation of cerebral functions. Kimura (1961) developed the standard DLT, in which pairs of spoken digits are presented through a headphone. In each trial, three digits are sequentially presented to the left ear (LE), while at the same time three other digits are sequentially presented to the right ear (RE). The participants are asked to report as many digits as possible after each trial. Kimura (1967) found that verbal stimuli presented to the RE are reported more accurately than verbal stimuli presented to the LE.According to the structural model proposed by Kimura (1967), this right-ear advantage (REA) is a consequence of the functional anatomical organisation of the central-auditory system and the cerebral representation of language functions. Although auditory information is processed in the

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Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis

Cited by 396 publications

References 17 publications

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Socioeconomic status is positively correlated with frontal white matter integrity in aging

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients

Age Effects in Identifying and Localising Dichotic Stimuli: A Corpus Callosum Deficit

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