J. of Medical Sciences

2011

DOI: 10.3923/jms.2011.145.151

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Normal Adiponectin Level and Glycemic Control could Delay Subclinical Atherosclerotic Changes in Lean Type 1 Diabetic Children

Hassan A Shora²,

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“…This study shows that adolescents with increased HbA 1c have increased cIMT. This is in accordance with Atwa and Shora, who demonstrated that good glycemic control and normal adiponectin levels may reverse subclinical atherosclerotic change in T1D children [ 12 ] and found a mean cIMT of 0.40 mm in children with T1D. On the other hand, Järvisalo et al found no difference in cIMT in children with T1D in comparison to normal children [ 38 ].…”

Section: Discussionsupporting

confidence: 87%

“…An adolescent was considered to have a poor metabolic control if HbA 1c was > 8.5%. Recent evidence has shown that there is a greater risk of harm from prolonged hyperglycemia that would occur if adolescents maintained an HbA 1c of 8.5% [ 12 , 13 ].…”

Section: Methodsmentioning

confidence: 99%

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Is subclinical atherosclerosis associated with visceral fat and fatty liver in adolescents with type 1 diabetes?

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et al. 2018

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IntroductionThere is a 3-fold higher prevalence of cardiovascular complications in patients with type 1 diabetes. The aim was to assess the relationship between subclinical atherosclerosis and visceral fat and fatty liver in diabetic adolescents.Material and methodsThe study was performed on 110 adolescents with type 1 diabetes (T1D) attending the Pediatric Diabetes Clinic of the University Hospital, Ismailia, Egypt. Their mean age was 14.2 ±0.7 years with a mean duration of diabetes 6 ±0.3 years. They were divided into group 1 which consisted of 55 adolescents with T1D and normal carotid intima media thickness (cIMT) and the second group which included 55 adolescents with T1D and subclinical atherosclerosis. All adolescents were normotensive, normo-albuminuric and had no retinopathy. Visceral fat thickness was measured as the distance between the anterior wall of the aorta and the posterior surface of the rectus abdominis muscle. Hepatic steatosis was diagnosed based on enlarged liver size and evidence of diffuse hyper-echogenicity of liver relative to kidneys.ResultsThe mean visceral fat was significantly higher in adolescents with increased cIMT (4.8 ±1.6) than in the normal thickness group (3.9 ±1.4). Liver size was also significantly larger in the former group (13.73 ±2.26 versus 12.63 ±2.20) (p = 0.022). After adjusting for other variables, logistic regression demonstrated that glycated hemoglobin (HbA1c) and fatty liver are independent factors affecting cIMT, OR = 1.426 (p < 0.05) and OR = 4.71 (p < 0.05).ConclusionsIn the present study, fatty liver and HbA1c were associated with subclinical atherosclerosis in lean adolescents with T1D.

“…This study shows that adolescents with increased HbA 1c have increased cIMT. This is in accordance with Atwa and Shora, who demonstrated that good glycemic control and normal adiponectin levels may reverse subclinical atherosclerotic change in T1D children [ 12 ] and found a mean cIMT of 0.40 mm in children with T1D. On the other hand, Järvisalo et al found no difference in cIMT in children with T1D in comparison to normal children [ 38 ].…”

Section: Discussionsupporting

confidence: 87%

“…An adolescent was considered to have a poor metabolic control if HbA 1c was > 8.5%. Recent evidence has shown that there is a greater risk of harm from prolonged hyperglycemia that would occur if adolescents maintained an HbA 1c of 8.5% [ 12 , 13 ].…”

Section: Methodsmentioning

confidence: 99%

Is subclinical atherosclerosis associated with visceral fat and fatty liver in adolescents with type 1 diabetes?

¹

,

²

,

³

et al. 2018

Self Cite

View full text Add to dashboard Cite

IntroductionThere is a 3-fold higher prevalence of cardiovascular complications in patients with type 1 diabetes. The aim was to assess the relationship between subclinical atherosclerosis and visceral fat and fatty liver in diabetic adolescents.Material and methodsThe study was performed on 110 adolescents with type 1 diabetes (T1D) attending the Pediatric Diabetes Clinic of the University Hospital, Ismailia, Egypt. Their mean age was 14.2 ±0.7 years with a mean duration of diabetes 6 ±0.3 years. They were divided into group 1 which consisted of 55 adolescents with T1D and normal carotid intima media thickness (cIMT) and the second group which included 55 adolescents with T1D and subclinical atherosclerosis. All adolescents were normotensive, normo-albuminuric and had no retinopathy. Visceral fat thickness was measured as the distance between the anterior wall of the aorta and the posterior surface of the rectus abdominis muscle. Hepatic steatosis was diagnosed based on enlarged liver size and evidence of diffuse hyper-echogenicity of liver relative to kidneys.ResultsThe mean visceral fat was significantly higher in adolescents with increased cIMT (4.8 ±1.6) than in the normal thickness group (3.9 ±1.4). Liver size was also significantly larger in the former group (13.73 ±2.26 versus 12.63 ±2.20) (p = 0.022). After adjusting for other variables, logistic regression demonstrated that glycated hemoglobin (HbA1c) and fatty liver are independent factors affecting cIMT, OR = 1.426 (p < 0.05) and OR = 4.71 (p < 0.05).ConclusionsIn the present study, fatty liver and HbA1c were associated with subclinical atherosclerosis in lean adolescents with T1D.

“…Although intensive glycemic control lowers the incidence and progression of microvascular complications, the morbidity associated with these complications is still increasing [37,38].…”

Section: Discussionmentioning

confidence: 99%

Correlation of NT-PROBNP levels with Physical and Biochemical Parameters in Egyptian Patients with Type 2 Diabetes

2020

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Complications of diabetes contribute greatly to the increased mortality and morbidity associated with this disease. Diabetic complications are divided into two main categories: macrovascular complications, including heart disease and stroke, and microvascular complications, which include retinopathy, nephropathy, and neuropathy. In the multinational A1chieve study, a large global study, based on nearly 68,000 type 2 diabetics, microvascular complications accounted for about half the total number of complications [2]. Diagnostic and prognostic values of B-type natriuretic peptides (BNP) and N-terminal fragment brain natriuretic peptides (NTpro-BNP) BNP was initially discovered in the porcine brain, but the largest concentrations are found in the heart [3]. BNP is mainly synthesized and secreted by cardiomyocytes of left ventricle (LV) in response to stretched cardiomyocytes by pressure overload or volume expansion of the ventricle.

Common Carotid Artery Intima-media Thickness and Atherosclerotic Plaques in Carotid Bulb in Patients with Chronic Kidney Disease on Hemodialysis: A Case-control Study

Abdi²,

et al. 2011

Pakistan J. of Biological Sciences

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The Common Carotid artery Intima-Media Thickness (CCIMT) can reflect systemic atherosclerosis in renal patients on hemodialysis. This study aimed to compare CCIMT measured by color Doppler ultrasonography between two groups including dialytic patients and normal subjects. In this case-control setting, 48 patients with Chronic Kidney Disease (CKD) on hemodialysis (case group) and 46 age and sex-matched healthy subjects (control group) were enrolled in this study. Color Doppler ultrasound was used to measure CCIMT and determine presence of atherosclerotic plaques in carotid bulb in both groups. Various laboratory parameters were also determined. Serum levels of triglyceride, total cholesterol, low-density lipoprotein, fasting sugar, ionized calcium, inorganic phosphorus and magnesium were comparable between the two groups. Hypertension and elevated levels of serum C-reactive protein, as well as the mean levels of serum non-fasting homocysteine and phosphate were significantly higher in the case group. Mean levels of serum high-density lipoprotein and albumin were significantly higher in the controls. Mean maximum CCIMT was significantly higher in the case group than in controls (0.73 +/- 0.15 vs. 0.68 +/- 0.08 mm, p = 0.01) even after adjusting for other confounding variables. Frequency of patients with atherosclerotic plaques in carotid bulbs was not significantly different between case and controls. In conclusion, this study showed that CCIMT is significantly higher in CKD patients on hemodialysis comparing with matched normal counterparts. Furthermore, this difference was independent of other conventional risk factors for atherosclerosis.

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