Complications of diabetes contribute greatly to the increased mortality and morbidity associated with this disease. Diabetic complications are divided into two main categories: macrovascular complications, including heart disease and stroke, and microvascular complications, which include retinopathy, nephropathy, and neuropathy. In the multinational A1chieve study, a large global study, based on nearly 68,000 type 2 diabetics, microvascular complications accounted for about half the total number of complications [2]. Diagnostic and prognostic values of B-type natriuretic peptides (BNP) and N-terminal fragment brain natriuretic peptides (NTpro-BNP) BNP was initially discovered in the porcine brain, but the largest concentrations are found in the heart [3]. BNP is mainly synthesized and secreted by cardiomyocytes of left ventricle (LV) in response to stretched cardiomyocytes by pressure overload or volume expansion of the ventricle.