1991
DOI: 10.1016/0924-8579(91)90019-a
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Norfloxacin, the first of a new class of fluoroquinolone antimicrobials, revisited

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Cited by 14 publications
(5 citation statements)
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“…Thus, it is rational to speculate that the upregulation of these genes will increase the survival of cells upon treatment with antibiotics that are capable of causing oxidative damage. To test our speculation, norfloxacin, a fluoroquinolone, inhibits DNA replication via affecting the activity of DNA gyrase, was used in the killing assay (Gadebusch and Shungu 1991). The norfloxacin MIC of EcN wildtype and derivatives was 1 μg/ mL.…”
Section: Transcriptional Interruption Of Ccdab and Hipab Affects The Expression Of Genes Involved In Stress Responsementioning
confidence: 99%
“…Thus, it is rational to speculate that the upregulation of these genes will increase the survival of cells upon treatment with antibiotics that are capable of causing oxidative damage. To test our speculation, norfloxacin, a fluoroquinolone, inhibits DNA replication via affecting the activity of DNA gyrase, was used in the killing assay (Gadebusch and Shungu 1991). The norfloxacin MIC of EcN wildtype and derivatives was 1 μg/ mL.…”
Section: Transcriptional Interruption Of Ccdab and Hipab Affects The Expression Of Genes Involved In Stress Responsementioning
confidence: 99%
“…Norfloxacin is widely used in the treatment of infectious conditions such as urinary tract infections, 46 prostate, skin, pulmonary and digestive infections. [47][48][49] It belongs to the fluoroquinolone family of drugs that target bacterial enzymes involved in DNA replication thereby inhibiting cell division. 50 The exact mechanism of its action, particularly from its uptake by the membrane through drug-lipid interactions to drug-DNA complex formation however is not well established.…”
Section: Introductionmentioning
confidence: 99%
“…Their mechanism of action is believed to be inhibition of DNA gyrase, preventing both replication and repair of DNA, affecting both actively growing (replication) and more slowly growing cells (repair processes). Fluoroquinolone activity, which is blocked by chloramphenicol, dinitrophenol, and amino acid starvation, requires both new protein synthesis and a functioning electron transport system (3,4,6,18).…”
mentioning
confidence: 99%