Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation

Venojärvi, Mika; Wasenius, Niko; Manderoos, Sirpa; Heinonen, Olli J.; Hernelahti, Miika; Lindholm, Harri; Surakka, Jukka; Lindström, Jaana; Aunola, Sirkka; Atalay, Mustafa; Eriksson, Johan G.

doi:10.3109/07853890.2012.727020

Cited by 60 publications

(150 citation statements)

References 53 publications

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“…Our data show that this type of physical activity performed by T2DM patients was associated with chemerin levels lower than those presented by the sedentary T2DM patients. In accordance with our results, Venojärvi et al 12 found that Nordic walking, fitness walking with specially designed poles, contributes to decreased chemerin levels in middle-aged men.…”

Section: Discussionsupporting

confidence: 93%

The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus

Neuparth¹,

Proença

Santos‐Silva³

et al. 2014

Journal of Investigative Medicine

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Section: Discussionsupporting

confidence: 93%

The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus

Neuparth¹,

Proença

Santos‐Silva³

et al. 2014

Journal of Investigative Medicine

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“…A large number of clinical studies demonstrated that elevated levels of circulating chemerin were associated with the onset of many traditional risk factors of CAD, such as sex [38], hypertension [39], and diabetes [40]. However, those findings were not observed in the present study.…”

Section: Discussioncontrasting

confidence: 80%

Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris

Lin

Liang

et al. 2014

Cardiovasc Diabetol

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BackgroundRecent evidence demonstrated that the circulating adipokines were associated with the onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and acute myocardial infarction (AMI). As a novel adipokine, chemerin has been related to atherosclerosis and the presence of coronary artery disease. However, the plasma levels of chemerin in patients with ACS have yet to be investigated.MethodsPlasma levels of chemerin and adiponectin were measured by an enzyme-linked immunosorbent assay (ELISA) in 60 patients with stable angina pectoris (SAP), 60 patients with UAP, 60 patients with AMI and 40 control patients. Left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were measured using a GE ViVid E7 ultrasonography machine, and the severity of coronary stenosis in patients was estimated with a Gensini coronary score following coronary angiography.ResultsPlasma chemerin levels were significantly higher in ACS patients than in the control and SAP groups, while plasma adiponectin levels were significantly lower in ACS patients than the control group. A correlation analysis revealed that plasma chemerin levels were positively correlated with the levels of C-reactive protein (CRP) (r = 0.29, P < 0.01) and LVEDD (r = 0.27, P < 0.01) but negatively correlated with LVEF (r = -0.45, P < 0.01) and that plasma adiponectin levels were positively correlated with LVEF (r = 0.53, P < 0.01) but negatively correlated with CRP (r = -0.33, P < 0.01) and LVEDD (r = -0.30, P < 0.01). Although significant correlations between chemerin, adiponectin and BMI or the Gensini coronary score were found in patients with SAP, neither chemerin nor adiponectin was correlated with BMI and the Gensini coronary score in patients with ACS. Furthermore, both chemerin (OR 1.103, 95% CI 1.065 to 1.142; P = 0.001) and adiponectin (OR 0.871, 95% CI 0.776 to 0.970; P = 0.018) were independently associated with the presence of ACS.ConclusionsChemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris.

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“…decreased chemerin) [Lee et al 2013;Venojarvi et al 2013;Stefanov et al 2014;Kim et al 2014;Neuparth et al 2014]. In a recent study by Neuparth and colleagues [Neuparth et al 2014] looking at T2DM patients, they found that subjects who maintained a regular walking regimen (⩾30 min, 3×/week) had significantly lower circulating chemerin levels (median [interquartile range] 134 [102-181] ng/ml), compared with their agematched sedentary counterparts (181 [156-199] ng/ml; p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

“…In other studies of this kind where an exercise intervention was used to observe effects on chemerin, exercise was often accompanied by other 'lifestyle modifications' such as a dietary intervention [Lee et al 2013;Venojarvi et al 2013;Stefanov et al 2014;Kim et al 2014;Neuparth et al 2014] as well as weight loss, which have both been shown to have favorable effects on circulating chemerin levels, irrespective of exercise [Bluher et al 2012;Sell et al 2010;Terra et al 2013]. A main advantage of using an animal model to examine the effects of exercise is the ability to more strictly control for potential confounding variables, namely dietary intake, compared with human trials.…”

Section: Discussionmentioning

confidence: 99%

“…A few recent studies have observed significant associations between lifestyle modifications, including aerobic and resistance training regimens (8 weeks to 1 year), and decreases in circulating chemerin levels [Lee et al 2013;Venojarvi et al 2013;Stefanov et al 2014;Kim et al 2014;Neuparth et al 2014] as well as correlations between decreases in chemerin levels and improvements in indices of insulin sensitivity [Lee et al 2013;Stefanov et al 2014;Kim et al 2014]. However, interventions in these recent studies often included dietary modifications in conjunction with exercise, and they did not attempt to tease out the independent effects of the diet and exercise components on chemerin or improvements in insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR

Lloyd

Zerfass

Heckstall

et al. 2015

Therapeutic Advances in Endocrinology

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Objectives: Chemerin concentrations are elevated in obesity and associated with inflammation and insulin resistance. Exercise improves insulin sensitivity, which may be facilitated by changes in chemerin. We explored the effects of chronic exercise on chemerin levels in dietinduced obese mice. Methods: We divided 40 mice into 4 groups: high-fat diet/exercise, high-fat diet/sedentary, normal diet/exercise, and normal diet/sedentary. A 9-week dietary intervention was followed by a 12-week exercise intervention (treadmill run: 11 m/min for 30 min, 3×/week). We analyzed blood samples before and after the exercise intervention. We used t-tests and linear regression to examine changes in chemerin, insulin resistance, and inflammatory markers, and associations between changes in chemerin and all other biomarkers. Results: Chemerin increased significantly across all mice over the 12-week intervention (mean ± SD = 40.7 ± 77.8%, p = 0.01), and this increase was smaller in the exercise versus sedentary mice (27.2 ± 83.9% versus 54.9 ± 70.5%, p = 0.29). The increase among the highfat diet/exercise mice was ~44% lower than the increase among the high-fat diet/sedentary mice (55.7 ± 54.9% versus 99.8 ± 57.7%, p = 0.12). The high-fat diet mice showed significant increases in insulin (773.5 ± 1286.6%, p < 0.0001) and homeostatic model assessment of insulin resistance (HOMA-IR; 846.5 ± 1723.3%, p < 0.01). Mediation analyses showed that increases in chemerin explained a substantial amount of the diet-induced increases in insulin and HOMA-IR. Conclusion: Chronic exercise may attenuate diet-driven increases in circulating chemerin, and the insulin resistance associated with a high-fat diet may be mediated by diet-induced increases in chemerin.

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Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation

Abstract: Nordic walking intervention seems to decrease chemerin and leptin levels, and subjects in this intervention group achieved the most beneficial effects on components of MeS.

Cited by 60 publications

References 53 publications

The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus

The Positive Effect of Moderate Walking Exercise on Chemerin Levels in Portuguese Patients with Type 2 Diabetes Mellitus

Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris

Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR

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