Nordic studies on late effects of treatment of cancer in childhood and adolescence

Garwicz, Stanislaw; Möller, Torgil; Olsen, Jørgen H.; Sankila, Risto

doi:10.1080/02841860410018557

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…These registries have provided data for a series of studies on cancer in childhood and adolescence during the last decade (2), and a description of their procedures and completeness can be found in ae ORIGINAL ARTICLE ae these papers or in Tulinius et al (3), for example, and is also available at www.ncu.cancer.dk (4).…”

Section: Patientsmentioning

confidence: 99%

Late mortality among five-year survivors of cancer in childhood and adolescence Differences between the Nordic Countries

Möller

Garwicz²,

Perfekt³

et al. 2004

Acta Oncologica

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The present study was aimed at assessing differences between the Nordic countries, if any, in late mortality among five-year survivors of childhood cancer. All cases diagnosed before the age of 20 years, between 1960 and 1989, were collected from all Nordic cancer registries. In total, 13 689 patients were identified as five-year survivors and during the extended follow-up 12.3) of them died. Mortality was analysed by decade of diagnosis, for all sites, and for leukaemia, Hodgkin's lymphoma, and central nervous system tumours separately. Analyses were done within a Cox proportional hazards regression framework with adjustments made for gender and age at diagnosis. Hazard ratios were calculated in relation to a weighted Nordic mean based on the proportion of five-year survivors in each country. Overall late mortality was significantly higher in Denmark and Finland than in Norway and Sweden. This could not be explained by inverse differences in five-year survival. The differences diminished over time and had disappeared in the last period. The pattern was similar for both genders. The disappearance of the differences was most probably the effect of a closer collaboration between Nordic paediatric oncologists with development and implementation of common protocols for treatment of childhood cancers in all countries.

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