Nordic Seaweed and Diabetes Prevention: Exploratory Studies in KK-Ay Mice

Abstract

Background: The global epidemic of type 2 diabetes (T2D) is a challenging health problem. Lifestyle changes, including nutrition therapy, areimportant for the prevention and management of T2D. Seaweeds contain several bioactive substances with potential health properties and may be a low-cost alternative functional food in the prevention of T2D. Objective: The aim of this study was to explore the preventive effects of dried Nordic seaweed species on diabetes in an animal model of T2D. Method: Fiftymale KK-Ay mice were randomly assigned to one of four diets: control diet (chow) or diets supplemented with Alaria esculenta (AE), Saccharina latissima (SL), or Palmaria palmata (PP). The effect of the interventions on the progression of T2D was monitored over 10 weeks and evaluated by circulating glucose, glycated hemoglobin (HbA1c), insulin, glucagon, and lipid levels. Results: The SL group had significantly lower bodyweight, lower HbA1c and insulin levels, as well as higher high density lipoprotein (HDL) cholesterol levels after the 10-week intervention than the control group. At the end of the study, the control group had significantly higher HbA1c (p < 0.001) than all of the seaweed groups. Conclusion: All seaweed groups improved HbA1C compared to control and Saccharinalatissima seaweed had concomitantly beneficial effects on glycemic control and lipid levels in KK-Ay diabetic mice.

Quantifying the Effect of Supplementation with Algae and Its Extracts on Glycolipid Metabolism: A Meta-Analysis of Randomized Controlled Trials

“…It can regulate intestinal health and reduce risk factors of diabetes, antiviral, anticancer, anticoagulation, etc. [ 15 ]. Dietary studies in Japan and South Korea showed that consumption of seaweed can reduce the incidence of chronic diseases such as cancer, hyperlipidemia and coronary heart disease [ 16 , 17 ].…”

“…Dietary studies in Japan and South Korea showed that consumption of seaweed can reduce the incidence of chronic diseases such as cancer, hyperlipidemia and coronary heart disease [ 16 , 17 ]. The existing evidence shows that algae, especially spirulina, has antioxidant, anti-inflammatory, antitumor, antiviral, antibacterial and other health-promoting functions, and has a positive therapeutic effect on hyperlipidemia, obesity, cardiac vascular disease (CVD) and diabetes [ 15 , 18 , 19 , 20 , 21 ]. Polyphenols extracted from seaweed are thought to contribute to reducing the risk of cardiovascular disease and diabetes complications due to hyperglycemia, hyperlipidemia, oxidative damage and chronic inflammation, as well as metabolic abnormalities [ 22 ].…”

Hypoglycemic activity of CPU2206: A novel peptide from sika ( Cervus nippon Temminck ) antler

“…The KK‐Ay mouse is spontaneously diabetic by means of transplantation of the diabetic gene into the C57BL/6J mouse, which exhibits profound obesity, hyperglycemia, and hyperinsulinemia (Sorensen et al, ). It is an ideal animal model for studying the etiopathogenesis of insulin resistance and type 2 diabetes.…”

“…The molecular weight of CPU2206 was 7,127.6 Da, estimated by MALDI‐TOF‐MS. Therefore, based on the former, we selected chemically induced T2D model (alloxan‐induced diabetic mice) and spontaneous T2D model (KK‐Ay mice) (Sorensen, Jeppesen, Christiansen, Hermansen, & Gregersen, ; Zheng et al, ) to test the toxicity and hypoglycemic activity of the peptide in vivo, aiming to explore the possibility of developing traditional Chinese medicine for diabetes treatment.…”

Beneficial Effects of Algerian Green Alga Ulva lactuca and Its Hydroethanolic Extract on Insulin Resistance and Cholesterol Reverse Transport in High-Fat/Streptozotocin Diabetic Rats

“…In the study of diabetes, all tested micro or macroalgae such as Caulerpa lentillifera , Spirulina versicolor , and Ulva lactuca shown antihyperglycemic effects in diabetic rats ( AbouZid et al, 2014 ). In addition, Sørensen et al (2019) showed that Nordic seaweed improves, glycosylated hemoglobin (HbA1c), glucose, and lipid profile, in diabetic mice. Moreover, ethanolic extract of Ulva reticulata induces a significant reduction in fasting blood glucose levels and an increase in plasma insulin activity (Ashok Kumar and Sharunetha, 2018 ).…”