Norcembranoidal Diterpenes from a Formosan Soft Coral Sinularia sp.

Yen, Wei-Hsuan; Hu, Li-Chung; Su, Jui‐Hsin; Lu, Mei‐Chin; Twan, Wen‐Hung; Yang, Show-Ying; Kuo, Yung-Chi; Weng, Ching‐Feng; Lee, Chia‐Hung; Kuo, Yueh‐Hsiung; Sung, Ping‐Jyun

doi:10.3390/molecules171214058

Cited by 18 publications

(19 citation statements)

References 33 publications

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“…850 has revealed that intramuscular injection leads to attenuation of inammation in a monosodium urate model of human gouty arthritis, and that the NP also suppressed neutrophil inltration and expression of related pro-inammatory cytokines. 851 While the mechanisms of cytotoxicity of the cembranoid 5-episinuleptolide acetate 852 appear to include inhibition of levels of Hsp90 and induction of apoptosis, 853 11-episinulariolide acetate 854 targets EGFmediated cytoplasmic calcium levels and inhibits COX-2 and IL-8 expression. 855 Of a range of exo-methylene lactonecontaining cembranoids tested for immunomodulatory effects, lobocrassin B (Lobophytum crassum) 856 was the most effective at blocking TNF-a production and attenuating LPSstimulated dendritic cell maturation and endocytosis.…”

Section: Sesquiterpenes Capillosananementioning

confidence: 99%

Marine natural products

et al. 2015

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This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Sesquiterpenes Capillosananementioning

confidence: 99%

Marine natural products

et al. 2015

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“…(Taitung County, Taiwan). 760 A collection of Sinularia sp. (Dongluo Is., Hainan, South China Sea) afforded sinuexibilins A-E 962-966, with the authors speculating about the potential artefactual nature of amethoxyfuranocembranoid 966.…”

Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2014

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This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…The straightforward one‐pot conversion of 5‐episinuleptolide into ineleganolide and sinulochmodin C in the presence of LiHMDS seems quite remarkable and provided convincing support for the biosynthesis proposals we made earlier to these novel structures. Interestingly, several months after this work was published, Yen et al isolated 5‐episinuleptolide acetate 119 from a soft coral Sinularia sp collected off the coast of Taiwan.…”

Section: Ineleganolide and Related Norcembranoidsmentioning

confidence: 99%