volume 190, issue 9, P4717-4724 2013
DOI: 10.4049/jimmunol.1300027
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Eric J. Seeley, Sophia S. Barry, Saisindhu Narala, Michael A. Matthay, Paul J. Wolters

Abstract: Effective host defense requires a robust, yet self-limited response to pathogens. A poorly calibrated response can lead to either bacterial dissemination due to insufficient inflammation or to organ injury due to excessive inflammation. Recent evidence suggests that the cholinergic anti-inflammatory reflex helps calibrate the immune response. However, the influence of peripheral noradrenergic neurons, which are primarily sympathetic neurons, in regulating immunity remains incompletely characterized. Using a m…

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