Noradrenergic activity and prediction of psychotic relapse following haloperidol withdrawal in schizophrenia

doi:10.1176/ajp.151.3.379

Cited by 31 publications

(3 citation statements)

References 51 publications

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“…Reported cluster sizes represented the size of a significant cluster after corrected for a small volume unless the cluster was significant at the whole brain level only. 7 et al, 1993;van Kammen et al, 1994;van Kammen & Kelley, 1991), and the effects of atypical antipsychotics on symptom reduction partly act through alpha-adrenergic receptors (Svensson, 2003).…”

Section: Differential Effects Of Stress On Salience Network Connectivmentioning

confidence: 99%

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

et al. 2020

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Background An adaptive neural stress response is essential to adequately cope with a changing environment. It was previously argued that sympathetic/noradrenergic activity during acute stress increases salience network (SN) connectivity and reduces executive control network (ECN) connectivity in healthy controls, with opposing effects in the late aftermath of stress. Altered temporal dynamics of these networks in response to stress are thought to play a role in the development of psychopathology in vulnerable individuals. Methods We exposed male healthy controls (n = 40, mean age = 33.9) and unaffected siblings of schizophrenia patients (n = 39, mean age = 33.2) to the stress or control condition of the trier social stress test and subsequently investigated resting state functional connectivity of the SN and ECN directly after and 1.5 h after stress. Results Acute stress resulted in increased functional connectivity within the SN in healthy controls, but not in siblings (group × stress interaction pfwe < 0.05). In the late aftermath of stress, stress reduced functional connectivity within the SN in both groups. Moreover, we found increased functional connectivity between the ECN and the cerebellum in the aftermath of stress in both healthy controls and siblings of schizophrenia patients. Conclusions The results show profound differences between siblings of schizophrenia patients and controls during acute stress. Siblings lacked the upregulation of neural resources necessary to quickly and adequately cope with a stressor. This points to a reduced dynamic range in the sympathetic response, and may constitute a vulnerability factor for the development of psychopathology in this at-risk group.

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Section: Differential Effects Of Stress On Salience Network Connectivmentioning

confidence: 99%

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

et al. 2020

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“…Reported cluster sizes represented the size of a significant cluster after corrected for a small volume unless the cluster was significant at the whole brain level only. van Kammen et al, 1994;van Kammen & Kelley, 1991), and the effects of atypical antipsychotics on symptom reduction partly act through alpha-adrenergic receptors (Svensson, 2003).…”

Section: Psychological Medicine 1043mentioning

confidence: 99%

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Leeuwen¹,

Vinkers

Vink

et al. 2019

Psychoneuroendocrinology

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“…However, it has also become clear that the noradrenergic system has extensive interactions with the dopamine system, and may play a role in schizophrenia, 8 and may also have a key role in psychotic relapse. 9 Interactions between the two systems have been well-studied in the cerebrospinal fluid and plasma of schizophrenic patients through their respective metabolites; plasma homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are the major degradation products of the monoamines dopamine and noradrenaline, respectively. Plasma HVA and MHPG are good predictors of response to antipsychotic treatment; 10 – 12 the effects of risperidone (a benzisoxazole derivative belonging to a family of atypical antipsychotic drugs) on plasma levels of HVA and MHPG have been related to its clinical efficacy in ameliorating the positive and negative symptoms of schizophrenia, respectively.…”

Section: Introductionmentioning

confidence: 99%

Plasma levels of 3-methoxy-4-hydroxyphenylglycol are associated with microstructural changes within the cerebellum in the early stage of first-episode schizophrenia: a longitudinal VBM study

Nishimura¹,

Kakeda²,

Abe³

et al. 2014

NDT

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The aims of this study are to determine how the interval changes of the brain structures in the early stage of first-episode schizophrenia relate to the interval changes in the clinical data, including the clinical symptoms of schizophrenia and catecholaminergic measures (plasma homovanillic acid [HVA] and 3-methoxy-4-hydroxyphenylglycol [MHPG]). Regional brain volumes and fractional anisotropy (FA)/mean diffusivity (MD) with diffusion tensor imaging (DTI) were measured at baseline and 6-month follow-up in a 3T magnetic resonance imaging (MRI) system in a cohort of 16 schizophrenic patients, who were in their first episode at the time of baseline MRI. At the time of baseline and follow-up MRI, all 16 patients underwent evaluations that included a psychopathological assessment (Positive and Negative Syndrome Scale [PANSS]) and peripheral catecholaminergic measures (plasma MHPG or HVA). For interval changes between baseline and follow-up MRI data (morphological change, MD, and FA), the correlation/regression analysis was performed as a series of single regression correlations in Statistical Parametric Mapping 5, with the interval changes in PANSS or plasma HVA and MHPG as the covariates of interest. Positive and inverse correlations contrasts were created, and in this preliminary analysis, a family-wise error-corrected threshold of P<0.05 was considered significant. In the correlation/regression analysis, a positive correlation between the FA in the right cerebellar vermis and the MHPG was observed. No significant correlations between the brain volume or MD and any laboratory data (plasma HVA and MHPG) were found. During the 6-month follow-up in the early stage of first-episode schizophrenia, the MHPG changes were correlated with the microstructural FA changes in the cerebellum, which may reflect the functional connections of the noradrenergic system in the cerebellum.

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Noradrenergic activity and prediction of psychotic relapse following haloperidol withdrawal in schizophrenia

Cited by 31 publications

References 51 publications

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

Plasma levels of 3-methoxy-4-hydroxyphenylglycol are associated with microstructural changes within the cerebellum in the early stage of first-episode schizophrenia: a longitudinal VBM study

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