Nootropic properties of GABA derivatives

Ostrovskaya, R. U.; Trofimov, S. S.

doi:10.1007/bf00804096

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Cited by 4 publications

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“…While earlier studies were mainly concentrate on baclofen, recent literature indicate renewed interest in the biological activities of b-phenyl-GABA. These include anticonvulsant 13 , antiepileptic 14 , antistress 15 , antiamnesic and antihypoxic 16 , antihypertensive 17 , and analgesic activities 18 . Because of its biological and pharmacological importance, several methodologies have been described focusing the total synthesis of baclofen 19,20 .…”

Section: Introductionmentioning

confidence: 99%

A new approach to the synthesis of (±)-methyl jasmonate and (±)-baclofen via conjugated addition of oxazoline cyanocuprate to Michael acceptors

Santos¹,

Clososki²,

Simonelli³

et al. 2001

J. Braz. Chem. Soc.

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Section: Introductionmentioning

confidence: 99%

A new approach to the synthesis of (±)-methyl jasmonate and (±)-baclofen via conjugated addition of oxazoline cyanocuprate to Michael acceptors

Santos¹,

Clososki²,

Simonelli³

et al. 2001

J. Braz. Chem. Soc.

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Experimental validation for a clinical study of GABA-positive substances in threatened abortion

et al. 1994

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The barouterography method revealed that intravenous phenibut in a dose of 50 mg/ kg and phenazepam in a dose of 2.5 mg/kg have a suppressive effect on the contractile isometric (fetus-expelling) activity of the uterus in nonpregnant and pregnant rabbits. Phenibut (150 mg/kg) and phenazepam (3 mg/kg) do not have an adverse effect on fetal development in rats. Clinical trials of phenibut and phenazepam as gravidoprotectors in threatened abortions are recommended.

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A new synthesis resolution and in vitro activities of (R)- and (S)-β-Phenyl-Gaba

et al. 1990

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Nootropic properties of GABA derivatives

Cited by 4 publications

References 3 publications

A new approach to the synthesis of (±)-methyl jasmonate and (±)-baclofen via conjugated addition of oxazoline cyanocuprate to Michael acceptors

A new approach to the synthesis of (±)-methyl jasmonate and (±)-baclofen via conjugated addition of oxazoline cyanocuprate to Michael acceptors

Experimental validation for a clinical study of GABA-positive substances in threatened abortion

A new synthesis resolution and in vitro activities of (R)- and (S)-β-Phenyl-Gaba

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