A new synthesis resolution and in vitro activities of (R)- and (S)-β-Phenyl-Gaba

A New Species and Genus of Kraussinidae (Brachiopoda) With a Note on Feeding

“…In those kraussinids in which the lophophore has been described however briefly-Kraussina rubra, Megerlina lamarckiana and Megerlia truncata (Davidson, 1887)-it is plectolophous with a short spiral arm : it has unfortunately not been described in Kraussina atkinsoni. It is proposed to place Pumilus in the Kraussinidae (Allan, 1940) for the following reasons :-( 1) the brachial skeleton resembles that of immature Kraussina rubra ; (2) the presence of spicules in the lophophore (present also in Megerlina davidsoni and in Megerlia truncata) ; (3) similar arrangement of muscles to that in Megerlia, with the posterior adductors striated. The muscular system of Kraussina has not yet been described in detail.…”

Transaminases and their Applications

“…The transformation of racemic 4-oxo-3-phenylbutyric acid ethyl ester to the desired (R)-enantiomer was catalyzed by an (R)-ω-transaminase [76]. For a complete theoretical conversion, the coproduct pyruvate was converted to lactate by a lactate dehydrogenase.…”

The synthesis and resolution of tritiated 4‐amino‐3‐phenylbutanoic acid ([3H]R‐ and [3H]S‐β‐phenylgaba)

“…Enantiomeric separation of racemic [3H]baclofen by HPLC using a chiral mobile phase has previously been successful, but this led to a much lower than expected recovery of radioactive product (12). We have recently shown that diastereoisomeric (R)-(-)-pantolactone esters (1 3) of N-phthalimido-P-phenylGABA could be separated by HPLC (11). We now report the use of the corresponding radiolabelled diastereoisomers, formed by catalytic reduction of the…”