Nonviral gene-delivery by highly fluorinated gemini bispyridinium surfactant-based DNA nanoparticles

Fisicaro, E.; Compari, Carlotta; Bacciottini, Franco; Contardi, Laura; Pongiluppi, Erika; Barbero, Nadia; Viscardi, Guido; Quagliotto, Pierluigi; Donofrío, Gaetano; Krafft, Marie Pierre

doi:10.1016/j.jcis.2016.10.032

Cited by 31 publications

(32 citation statements)

References 41 publications

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“…Some gemini surfactants with sugar substituent, peptide moiety [225,226] or cholesterol-based diquaternary ammonium gemini surfactant [227] were tested as a gene transfection vectors. It was recently shown that hydroxyethylated gemini surfactants [228], fluorinated bispyridinium gemini surfactants [229] and geminis derived from cysteine [230,231] can be also used for this application.…”

Section: Gene Therapy and Bioimagingmentioning

confidence: 99%

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Brycki¹,

Kowalczyk²,

Szulc³

et al. 2017

Application and Characterization of Surfactants

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Gemini cationic surfactants are compounds which are composed of two hydrophilic head groups and two hydrophobic tails linked by a spacer at the head groups or closed to them. The spacer can be either hydrophobic or hydrophilic. It can be rigid or flexible. The neutral charge of the molecule is retained by the presence of organic or inorganic counterions. Critical micelle concentrations (CMCs), surface tension (γ) and minimal inhibitory concentration (MIC) are dozen times lower than corresponding parameters of monomeric surfactants. The unique properties of gemini surfactants with a wide range of hydrophiliclipophilic balance (HLB) make them a very useful, innovative material in detergents, cosmetics, personal care products, additives for paints and coatings, biocides, material science, organic synthesis, pharmacy, textiles, enhanced oil recovery, nanotechnology, petroleum and many other branches of life. A large number of papers concerning gemini surfactants have been published so far. This review presents a synthetic look at current work devoted to structure, synthesis and applications of gemini surfactants.

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Section: Gene Therapy and Bioimagingmentioning

confidence: 99%

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Brycki¹,

Kowalczyk²,

Szulc³

et al. 2017

Application and Characterization of Surfactants

View full text Add to dashboard Cite

show abstract

“…Because of their unique properties, gemini surfactants are used in different areas such as household, medicine, pharmacy or petrochemistry [17][18][19] as biocides [20], corrosion inhibitors [21,22], detergents [7], emulsifiers [23], gene delivery agents [24], in micellar catalysis [25,26] and much more. The use of gemini surfactants is increasing and consequently their potential risk to the aquatic environment also increases.…”

Section: Introductionmentioning

confidence: 99%

Cationic gemini surfactants containing an O-substituted spacer and hydroxyethyl moiety in the polar heads: Self-assembly, biodegradability and aquatic toxicity

Kaczerewska

Brycki

Ribosa

et al. 2018

Journal of Industrial and Engineering Chemistry

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Micellization and some ecological properties of new cationic gemini surfactants with oxygensubstituted spacer and hydroxyethyl groups connected to the polar heads have been studied. The incorporation of a hydroxyethyl group in the polar head favors self-aggregation whereas the presence of the oxygen in the spacer increases critical micelle concentration. Surfactants investigated are not biodegradable due to their toxic effect on microorganisms responsible for biodegradation. Aquatic toxicity increases with the hydrophobic chain and decreases by increasing the hydrophilicity of spacer and polar heads. New gemini surfactants are less toxic to the aquatic environment than monomeric surfactants and non-oxygen-containing gemini surfactants.

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“…Due to their excellent properties, gemini surfactants can have many potential industrial applications such as cleaning agents and detergents, biocides, preservatives and solubilisation agents in textile dying [7,[9][10][11][12][13][14]. They can be also applied in nanotechnology as gene delivery agents and supramolecular solvents [15][16][17]. Recently, greater attention has been paid to the use of gemini surfactants as corrosion inhibitors (CIs) for metals, especially in acidic environments [18][19][20][21][22][23][24].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Efficiency of cationic gemini surfactants with 3-azamethylpentamethylene spacer as corrosion inhibitors for stainless steel in hydrochloric acid

Kaczerewska

Leiva-García

Akid

et al. 2017

Journal of Molecular Liquids

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Nonviral gene-delivery by highly fluorinated gemini bispyridinium surfactant-based DNA nanoparticles

Cited by 31 publications

References 41 publications

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Cationic gemini surfactants containing an O-substituted spacer and hydroxyethyl moiety in the polar heads: Self-assembly, biodegradability and aquatic toxicity

Efficiency of cationic gemini surfactants with 3-azamethylpentamethylene spacer as corrosion inhibitors for stainless steel in hydrochloric acid

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