Nontraumatic Pediatric Intracerebral Hemorrhage

Boulouis, Grégoire; Blauwblomme, Thomas; Hak, Jean-François; Benichi, Sandro; Kirton, Adam; Meyer, Philippe; Chevignard, Mathilde; Tournier‐Lasserve, Elisabeth; Mackay, Mark T; Chabrier, Stéphane; Cordonnier, Charlotte; Kossorotoff, Manoëlle; Naggara, Olivier

doi:10.1161/strokeaha.119.025783

Cited by 58 publications

(50 citation statements)

References 78 publications

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“…If a patient is not treated on time, the patient may proceed to coma and, ultimately, death because of cerebral edema or cerebral hemorrhage [7]. In our case, the patient was diagnosed very early, and appropriate treatment was started on time, so neurologically as well as physically, the patient is doing well to date.…”

Section: Discussionmentioning

confidence: 76%

Isovaleric Acidemia: A Rare Case of an Inborn Error of Metabolism

Khan

Zahid

Khan³

et al. 2020

Cureus

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Isovaleric acidemia (IVA) is an autosomal recessive disease of the leucine metabolism due to a deficiency of isovaleryl-CoA dehydrogenase (IVD). We report the case of a six-month-old girl admitted with a seven-day history of fever, cough, stridor, vomiting, and respiratory distress. Second-degree consanguinity was documented between the parents. Urine organic acid analysis by gas chromatography-mass spectrometry showed marked excretion of 3hydroxybutyric acid along with moderate excretion of 3-hydroxy-isovaleric acid. Isovaleric acidemia was diagnosed based on history, examination, and laboratory evaluation. The patient managed with fluid resuscitation, correction of her metabolic acidosis, antibiotics, and supportive care.

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Section: Discussionmentioning

confidence: 76%

Isovaleric Acidemia: A Rare Case of an Inborn Error of Metabolism

Khan

Zahid

Khan³

et al. 2020

Cureus

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“…In children with acute focal neurological deficits, most pediatric stroke guidelines recommend brain magnetic resonance imaging (MRI) as first imaging modality especially in suspected ischemic stroke, where computed tomography (CT) may be less sensitive for detection of early ischemic changes [17,18]. Yet, in children with suspected intracranial hemorrhage, CT has several advantages, including greater accessibility and faster acquisition time [3] limiting the risk of requiring sedation for imaging acquisition, hence often counterbalancing the disadvantages of radiation and iodine contrast exposure [17], in the context of a life-threatening condition. Altogether, MRI should be preferred in stable and calm children, and CT favored in children with vigilance alteration, agitation or acutely worsening neurological symptoms.…”

Section: Acute Imaging Work-upmentioning

confidence: 99%

“…While accounting for a minority of adult strokes, hemorrhagic strokes account for half of all strokes seen in children, and occur in approximately 1-2 per 100,000 children per year [1,2]. The etiologies of hemorrhagic stroke differ in children as well; hypertensive hemorrhage rarely occurs in children, and cerebral amyloid angiopathy is almost exclusively an adult disease [3]. Trauma is the most common cause of intracerebral hemorrhage (ICH) in children, and the distinction between traumatic versus spontaneous hemorrhage can be challenging.…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging of Pediatric Intracerebral Hemorrhage

Sporns

Psychogios

Fullerton

et al. 2020

JCM

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Hemorrhagic strokes account for half of all strokes seen in children, and the etiologies of these hemorrhagic strokes differ greatly from those seen in adult patients. This review gives an overview about incidence and etiologies as well as presentation of children with intracerebral hemorrhage and with differential diagnoses in the emergency department. Most importantly it describes how neuroimaging of children with intracerebral hemorrhage should be tailored to specific situations and clinical contexts and recommends specific imaging protocols for acute and repeat imaging. In this context it is important to keep in mind the high prevalence of underlying vascular lesions and adapt the imaging protocol accordingly, meaning that vascular imaging plays a key role regardless of modality. Magnetic resonance imaging (MRI), including advanced sequences, should be favored whenever possible at the acute phase.

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“…La incidencia de MAVc alcanza el 70 % de todas las anomalías vasculares cerebrales y tiene una prevalencia anual de 10 a 12 en 100 000 niños (2) . Cada año, las complicaciones hemorrágicas ocurren en 4 de cada 100 pacientes con estas malformaciones, mientras que el riesgo de muerte representa el 15-20 % (8)(9)(10) . Es importante brindar una atención adecuada y especializada acompañada de técnicas de diagnóstico por imágenes para una correcta elección terapéutica.…”

Section: Introductionunclassified

Características clínico-epidemiológicas y manejo de las malformaciones arteriovenosas cerebrales en el Servicio de Neurocirugía del Instituto Nacional de Salud del Niño San Borja, 2015-2017

et al. 2021

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Objetivo: Describir las características clínico-epidemiológicas y el manejo de las malformaciones arteriovenosas cerebrales (MAVc) en pacientes atendidos en el Instituto Nacional de Salud del Niño San Borja (INSN-SB). Materiales y métodos: Estudio retrospectivo y descriptivo en pacientes con malformaciones arteriovenosas cerebrales atendidos en el Instituto Nacional de Salud del Niño San Borja entre 2015-2017. Los datos fueron procesados y analizados en el programa SPSS versión 22. Las variables cualitativas se expresaron en frecuencias absolutas y relativas. Resultados: Se identificaron 41 malformaciones arteriovenosas cerebrales. La mayoría se presentó en el grupo etario entre los 6 y 12 años (56,10 %) y en el sexo femenino (65,90 %). La ruptura de las malformaciones ocurrió en el 80,49 % de casos, y el 92,70 % de los pacientes tuvo cefalea como manifestación clínica predominante. Las localizaciones más frecuentes fueron el lóbulo frontal (36,60 %) y el hemisferio cerebral izquierdo (51,20 %). El grado más común de las malformaciones arteriovenosas cerebrales fue el III (43,90 %) de la clasificación de Spetzler-Martin. La embolización fue el tratamiento empleado con mayor frecuencia (39 %) y la mortalidad alcanzó el 2,40 %. Conclusiones: Los grupos que presentan malformaciones arteriovenosas cerebrales con mayor frecuencia son las mujeres y los pacientes entre 6 y 12 años. Un poco más de la mitad de los pacientes tuvieron ruptura de la lesión. La cefalea es el síntoma predominante y las malformaciones más frecuentes corresponden al grado III de la escala de Spetzler-Martin. La embolización es el método quirúrgico más empleado y la mortalidad fue baja.

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Nontraumatic Pediatric Intracerebral Hemorrhage

Cited by 58 publications

References 78 publications

Isovaleric Acidemia: A Rare Case of an Inborn Error of Metabolism

Isovaleric Acidemia: A Rare Case of an Inborn Error of Metabolism

Neuroimaging of Pediatric Intracerebral Hemorrhage

Características clínico-epidemiológicas y manejo de las malformaciones arteriovenosas cerebrales en el Servicio de Neurocirugía del Instituto Nacional de Salud del Niño San Borja, 2015-2017

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