NonToxic Silver/Poly-1-Vinyl-1,2,4-Triazole Nanocomposite Materials with Antibacterial Activity

Abstract

Novel silver/poly-1-vinyl-1,2,4-triazole nanocomposite materials—possessing antimicrobial activity against Gram-positive and Gram-negative bacteria—have been synthesized and characterized in the solid state and aqueous solution by complex of modern physical-chemical and biologic methods. TEM-monitoring has revealed the main stages of microbial cell (E. coli) destruction by novel nanocomposite. The concept of direct polarized destruction of microbes by nanosilver proposed by the authors allows the relationship between physicochemical and antimicrobial properties of novel nanocomposites. At the same time, it was shown that the nanocomposite was nontoxic to the fibroblast cell culture. Thus, the synthesized nanocomposite combining antibacterial activity against Gram-positive and Gram-negative bacteria as well as the absence of toxic effects on mammalian cells is a promising material for the development of catheters, coatings for medical devices.

One-Pot Preparation of Metal–Polymer Nanocomposites in Irradiated Aqueous Solutions of 1-Vinyl-1,2,4-triazole and Silver Ions

“…Among the important properties of this polymer are pharmacological activity, nontoxicity, and resistance to aggressive media. Silver nanoparticles incorporated into the PVT matrix exhibit high antibacterial, immunomodulatory, and cytotoxic activity, enhance body defenses, and exert a protective effect against the Yersinia pestis bacteria and anthrax [ 27 , 28 , 29 ].…”

Synthesis, Properties, and Biological Activity of Poly(1-vinyl-1,2,4-triazole) and Silver Nanocomposites Based on It

“…According to photon correlation spectroscopy, PVT macromolecules occur in an aqueous solution as statistical coils with an average hydrodynamic diameter of 292 nm ( Fig. 1b ) [ 64 ].…”

Green Synthesis of Stable Nanocomposites Containing Copper Nanoparticles Incorporated in Poly-N-vinylimidazole

“…In the 13 The synthesized PVI was characterized by 1 H and 13 C NMR analysis (Figure 2). The 1 H spectrum of PVI contains the characteristic proton signals from the imidazole ring at 6.64-7.06 ppm (2,4,5). The broadened signals at 1.98-2.11 ppm ( 7) belong to protons of the -CH 2 -backbone groups.…”

“…The specific properties of metals in an ultradispersed state open up wide opportunities for the creation of new effective catalysts, sensor systems, and drugs with high biological activity for use in medicine, ecology, and agriculture [ 1 , 2 , 3 , 4 , 5 , 6 ]. Metal nanoparticles are the objects of active study, due to their increased reactivity, interesting biological properties, small size, and ability to penetrate into the cells of the body [ 7 , 8 , 9 , 10 , 11 , 12 ].…”