Nonsurgical transurethral collagen denaturation for stress urinary incontinence in women: 18‐month results from a prospective long‐term study

Elser, Denise M.; Mitchell, G.K.; Miklos, John R.; Nickell, Kevin G.; Cline, Kevin; Winkler, Harvey A.; Wells, W. Glen

doi:10.1002/nau.20875

Cited by 16 publications

(13 citation statements)

References 14 publications

(17 reference statements)

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“…Non-ablative low-energy RF energy has been suggested as a possible treatment for SUI [16, 17] and this treatment modality has received FDA (Renessa/Lyrette, Novasys Medical Inc., Newark, CA, USA) approval for its management [17]. With the low energy heat exposure of the proximal urethra, small regions of periurethral collagen get denatured, thereby leading to a change in tissue compliance and improving its function.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Heat Exposure on Vaginal Smooth Muscle Cells: Elastin and Collagen Production

Kozma

Candiotti

Póka

et al. 2018

Gynecol Obstet Invest

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Aims: To evaluate smooth muscle cells (SMCs) proliferation and elastin and collagen production after heat exposure (65°C). Methods: Samples were taken from the anterior vaginal wall, SMCs were cultured, and heated to 65°C for 30 and 60 s. Cell proliferation was assessed; tropoelastin and collagen production was measured. Results: Heat does not affect SMC proliferation at 65°C neither at 30 nor at 60 s. Surface-deposited elastin level was significantly increased after heat exposure (mean ± SD, 30 s 155 ± 5% of control [p < 0.01] and 60 s 516 ± 40% of control [p < 0.01]). Tropoelastin levels in the culture media were significantly lower after 60 s of heat exposure (mean ± SD, 30 s 102 ± 5% of control [p = ns] and 60 s 70 ± 2% of control [p = 0.04]). Significant increase in surface-deposited collagen production was found (mean ± SD, 30 s 170 ± 6% of control [p < 0.01] and 60 s 123 ± 6% of control [p < 0.01]), but no such elevation was measured in the media after heat exposure (mean ± SD, 30 s 120 ± 20% of control [p = ns] and 60 s 100 ± 20% of control [p = ns]). Conclusion: When SMCs are exposed to heat there is significant elevation in collagen and elastin production. Changes in the composition of the extracellular matrix after heat exposure may contribute to vaginal wall remodeling.

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Section: Resultsmentioning

confidence: 99%

The Effects of Heat Exposure on Vaginal Smooth Muscle Cells: Elastin and Collagen Production

Kozma

Candiotti

Póka

et al. 2018

Gynecol Obstet Invest

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“…A summary of prospective trials employing Renessa is presented in Table 1 [18–22]. Inclusion criteria common to all studies were SUI and urethral hypermobility, with exclusion of those with a history of previous anti-incontinence surgery and those with primary urge-associated leakage in the presence of mixed incontinence.…”

Section: Clinical Datamentioning

confidence: 99%

Transurethral Radiofrequency Collagen Denaturation for Treatment of Female Stress Urinary Incontinence: A Review of the Literature and Clinical Recommendations

Lukban

2012

Obstetrics and Gynecology International

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Stress urinary incontinence is a prevalent condition in women with a significant negative effect on quality of life. Intervention includes behavioral modification, intravaginal devices, pelvic floor muscle exercises, biofeedback, functional electrical stimulation, and surgical procedures. We will review a new in-office procedure for the treatment of SUI that may serve as a viable nonsurgical option.

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“…Stress urinary incontinence (SUI) is a common medical condition affecting approximately 30% of postpartum women and interfering with their quality of life [1,2]. It is defined as a "complaint of involuntary loss of urine upon effort or physical exertion (e.g., sporting activities), or sneezing or coughing" according to the International Continence Society (ICS) guidelines [3].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Human Adipose-Derived Stem Cell Exosomes in Stress Urinary Incontinence – An in Vitro and in Vivo Study

Zhou

et al. 2018

Cell Physiol Biochem

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Background/Aims: To evaluate whether local injection of exosomes derived from human adipose-derived stem cells (hADSCs) facilitates recovery of stress urinary incontinence (SUI) in a rat model. Methods: For the in vitro study, a Cell Counting Kit-8 (CCK-8) array and proteomic analysis were performed. For the in vivo study, female rats were divided into four groups: sham, SUI, adipose-derived stem cell (ADSC), and exosomes (n = 12 each). The SUI model was generated by pudendal nerve transection and vaginal dilation. Vehicle, hADSCs, or exosomes were injected into the peripheral urethra. After 2, 4, and 8 weeks, the rats underwent cystometrography and leak point pressure (LPP) testing, and tissues were harvested for histochemical analyses. Results: The CCK-8 experiment demonstrated that ADSC-derived exosomes could enhance the growth of skeletal muscle and Schwann cell lines in a dose-dependent manner. Proteomic analysis revealed that ADSC-derived exosomes contained various proteins of different signaling pathways. Some of these proteins are associated with the PI3K-Akt, Jak-STAT, and Wnt pathways, which are related to skeletal muscle and nerve regeneration and proliferation. In vivo experiments illustrated that rats of the exosome group had higher bladder capacity and LPP, and had more striated muscle fibers and peripheral nerve fibers in the urethra than rats of the SUI group. Both urethral function and histology of rats in the exosome group were slightly better than those in the ADSC group. Conclusions: Local injection of hADSC-derived exosomes improved functional and histological recovery after SUI.

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Nonsurgical transurethral collagen denaturation for stress urinary incontinence in women: 18‐month results from a prospective long‐term study

Abstract: Transurethral collagen denaturation resulted in significant improvements in stress leaks and quality of life for at least 18 months. This procedure offers a safe, effective, nonsurgical treatment option for women with SUI.

Cited by 16 publications

References 14 publications

The Effects of Heat Exposure on Vaginal Smooth Muscle Cells: Elastin and Collagen Production

The Effects of Heat Exposure on Vaginal Smooth Muscle Cells: Elastin and Collagen Production

Transurethral Radiofrequency Collagen Denaturation for Treatment of Female Stress Urinary Incontinence: A Review of the Literature and Clinical Recommendations

Therapeutic Potential of Human Adipose-Derived Stem Cell Exosomes in Stress Urinary Incontinence – An in Vitro and in Vivo Study

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