Nonsurgical Laser Treatment (NSLT) of Central and Peripheral Nervous System Injuries

Longo, Leonardo

doi:10.1089/pho.2016.4259

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…From December 2003 until December 2018, we treated hundreds of patients with Central Nervous System Injuries (CNSI), using Non-Surgical Laser Therapy (NSLT) (1) obtaining good results in terms of sensitivity and movement (2). To increase muscle strength and to further explore new emerging synergies, we have also started using a physical therapy practice based on the most current knowledge about motor control (3,4), called Grimaldi's Muscle Shortening Maneuver (GMSM) (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Effects of laser therapy and Grimaldi’s muscle shortening maneuver on spasticity in central nervous system injuries

Longo

Cherubini²,

Mangé³

et al. 2022

Laser Ther

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Background an Aims: For 2003 year until today we treated hundreds of patients with Central Nervous System Injuries (CNSI), using Non-Surgical Laser Therapy (NSLT) obtaining good results in terms of sensibility and movement. In order to increase muscle strength and to further explore new emerging synergies, we have also started using a physical therapy practice based on the most current knowledge about the motor control, called Grimaldi’s Muscle Shortening Maneuver (GMSM). Spasticity is often the most disabling symptom and the current therapies are still not able to heal it at all. The goal of our study is to suggest a new way of treatment of spasticity, supporting it with objective measurements of muscle thresholds. Materials and Methods: In 2016-2017, 36 patients with traumatic or degenerative CNSI were enrolled. Lasers used were 808 nm, 10600 nm, and 1064 nm, applied with a first cycle of 20 sessions, four a day. Patients were subjected to Grimaldi’s Muscle Shortening Maneuver (MSM) twice a day, ten sessions at all, working selectively on hypertonic muscles and their antagonists. Before treatment, tonic stretch reflex thresholds (TSRTs) in Gastrocnemius Lateralis (GL) were assessed through a surface electromyography (sEMG) device paired with an electrogoniometer. Antagonist muscle force (Tibialis Anterioris) was assessed by some electronic hand-held dynamometers. For the clinical measure, we used the Modified Ashworth Scale (MAS). All tests have been performed at the baseline (before starting treatments), after one week (at the end of the last treatment) and after a month. Results: Results were considered positive if the instrumental assessment procedure showed modifications in TSRT values and subjects improved their antagonist muscle strength. Results showed modifications in TSRT values at every follow up. The average comparison between the follow-ups was always statistically significant (p .000). The increase in Tibialis Anterioris muscle strength was statistically significant as well (p .000). MAS showed some differences between followups but not all of them are statistically significant (T0-T1 p .063, T1-T2 p .001, T0-T2 p .000). Encouraging results suggest a possible correlation between laser and MSM therapies and modifications of TSRT in spastic muscles. Conclusion: Associating laser treatment and Grimaldi’s Muscle Shortening Maneuver (MSM) seems to be effective on spasticity in patients affected by traumatic or degenerative CNSI. Obviously, this kind of study design showed a lot of limits however this clinical series could be an important hint for every researcher working in the complex field of spasticity, a symptom that is poorly defined and hardly treated.

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Section: Introductionmentioning

confidence: 99%

Effects of laser therapy and Grimaldi’s muscle shortening maneuver on spasticity in central nervous system injuries

Longo

Cherubini²,

Mangé³

et al. 2022

Laser Ther

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“…16 Not only does photobiomodulation therapy (PBMT) reduce the harmful effects of H2O2, but also it increases the expression of antioxidants and reduces oxidative stress. 17 Nerve regeneration and tissue healing are positively affected by low-energy lasers. These lasers support chiropractic interventions in an effective way.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Photobiomodulation Therapy and Bone Marrow Stromal Stem Cells Conditioned Media on Pheochromocytoma Cell Line 12 Against Oxidative Stress Induced by Hydrogen Peroxide

et al. 2019

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Introduction: Bone marrow stromal stem cells (BMSCs), a type of adult stem cells, secrete bioactive molecules such as trophic factors, growth factors, chemokine and cytokines that may be effective against oxidative stress in neurodegenerative diseases. In this study, we examined the protective effect of BMSCs conditioned media (CM) and photobiomodulation therapy (PBMT) on PC12 cells exposed to H2O2 as an oxidative injury model. Methods: BMSCs were cultured and confirmed by flow cytometry analysis and underwent osteogenic and adipogenic differentiation. Then, PC12-H2O2 cells were co-treated with BMSCs-CM and PBMT. The effect of BMSCs-CM and PBMT (He-Ne laser, 632.8nm, 3mW, 1.2J/ cm2 , 378s) on Bax/Bcl2 expression, cell viability, was assessed by real-time PCR and MTT assay. The length of the Neurite and cell body areas were assessed by Cell A software. Results: Flowcytometry analysis, as well as osteogenic and adipogenic staining, confirmed the BMSCs. The length of the Neurite was the highest in the group which received CM+PBMT and cell body areas were significant in CM+PBMT compared to other groups. Based on our results, elevating H2O2 concentration increased cell death significantly and using concentrations of 250 µM resulted in a dramatic increase in the mortality compared to the other groups. Conclusion: Our result demonstrated that the combination of CM +PBMT has a protective effect on PC12 cells against oxidative stress.

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Laser treatment of central nervous system injuries: an update and prospects

Longo¹

2019

Photobiomodulation in the Brain

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Nonsurgical Laser Treatment (NSLT) of Central and Peripheral Nervous System Injuries

Cited by 3 publications

References 5 publications

Effects of laser therapy and Grimaldi’s muscle shortening maneuver on spasticity in central nervous system injuries

Effects of laser therapy and Grimaldi’s muscle shortening maneuver on spasticity in central nervous system injuries

Protective effect of Photobiomodulation Therapy and Bone Marrow Stromal Stem Cells Conditioned Media on Pheochromocytoma Cell Line 12 Against Oxidative Stress Induced by Hydrogen Peroxide

Laser treatment of central nervous system injuries: an update and prospects

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