Nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opioids for acute renal colic

Nonopioid Pain Management Pathways for Stone Disease

“…A Cochrane Review published by Afshar et al included six studies that compared NSAIDs with antispasmodics such as hyoscine (an anticholinergic). 24 Results were mixed, in that NSAIDs were more effective than hyoscine (four studies) in lowering pain scores by 50% (RR 2.44, 95% CI 1.61–3.70); however, no differences were seen in total VAS pain score improvement or need for rescue medication. 24 In the context of these findings, anti-spasmodics are not considered first-line or second-line options for management of acute renal colic.…”

Nonopioid Pain Management Pathways for Stone Disease

“…A Cochrane Review published by Afshar et al included six studies that compared NSAIDs with antispasmodics such as hyoscine (an anticholinergic). 24 Results were mixed, in that NSAIDs were more effective than hyoscine (four studies) in lowering pain scores by 50% (RR 2.44, 95% CI 1.61–3.70); however, no differences were seen in total VAS pain score improvement or need for rescue medication. 24 In the context of these findings, anti-spasmodics are not considered first-line or second-line options for management of acute renal colic.…”

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

“…A total of 12 systematic reviews on urinary stones were included in the present study 12–23 which were published in the Cochrane Database of Systematic Reviews up to January 1, 2022. Details of the included systematic reviews are presented in Table 2.…”

Ureteral Access Sheath Influence on the Ureteral Wall Evaluated by Cyclooxygenase-2 and Tumor Necrosis Factor-α in a Porcine Model

“…The effects of NSAID on pain and inflammation have long been utilized in the treatment of acute renal colic. 13 A selective COX-2 inhibitor and a nonselective COX inhibitor reduced ureteral contractility in both porcine and human ureteral segments in vitro. 14 Treatment with the COX-2 inhibitor, Celecoxib, completely abolished the expression of COX-2 and prostaglandin E2 (PGE2) in the smooth muscle layer of ligated ureters, and the severity of hydroureter and fibrosis of the muscle layer was significantly attenuated in a rat experiment.…”

Nonopioid Pain Management Pathways for Stone Disease

“…A Cochrane Review published by Afshar et al included six studies that compared NSAIDs with antispasmodics such as hyoscine (an anticholinergic). 24 Results were mixed, in that NSAIDs were more effective than hyoscine (four studies) in lowering pain scores by 50% (RR 2.44, 95% CI 1.61–3.70); however, no differences were seen in total VAS pain score improvement or need for rescue medication. 24 In the context of these findings, anti-spasmodics are not considered first-line or second-line options for management of acute renal colic.…”

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

“…A total of 12 systematic reviews on urinary stones were included in the present study 12–23 which were published in the Cochrane Database of Systematic Reviews up to January 1, 2022. Details of the included systematic reviews are presented in Table 2.…”

Ureteral Access Sheath Influence on the Ureteral Wall Evaluated by Cyclooxygenase-2 and Tumor Necrosis Factor-α in a Porcine Model

“…The effects of NSAID on pain and inflammation have long been utilized in the treatment of acute renal colic. 13 A selective COX-2 inhibitor and a nonselective COX inhibitor reduced ureteral contractility in both porcine and human ureteral segments in vitro. 14 Treatment with the COX-2 inhibitor, Celecoxib, completely abolished the expression of COX-2 and prostaglandin E2 (PGE2) in the smooth muscle layer of ligated ureters, and the severity of hydroureter and fibrosis of the muscle layer was significantly attenuated in a rat experiment.…”

Nonopioid Pain Management Pathways for Stone Disease

“…A Cochrane Review published by Afshar et al included six studies that compared NSAIDs with antispasmodics such as hyoscine (an anticholinergic). 24 Results were mixed, in that NSAIDs were more effective than hyoscine (four studies) in lowering pain scores by 50% (RR 2.44, 95% CI 1.61–3.70); however, no differences were seen in total VAS pain score improvement or need for rescue medication. 24 In the context of these findings, anti-spasmodics are not considered first-line or second-line options for management of acute renal colic.…”

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

“…A total of 12 systematic reviews on urinary stones were included in the present study 12–23 which were published in the Cochrane Database of Systematic Reviews up to January 1, 2022. Details of the included systematic reviews are presented in Table 2.…”

Ureteral Access Sheath Influence on the Ureteral Wall Evaluated by Cyclooxygenase-2 and Tumor Necrosis Factor-α in a Porcine Model

“…The effects of NSAID on pain and inflammation have long been utilized in the treatment of acute renal colic. 13 A selective COX-2 inhibitor and a nonselective COX inhibitor reduced ureteral contractility in both porcine and human ureteral segments in vitro. 14 Treatment with the COX-2 inhibitor, Celecoxib, completely abolished the expression of COX-2 and prostaglandin E2 (PGE2) in the smooth muscle layer of ligated ureters, and the severity of hydroureter and fibrosis of the muscle layer was significantly attenuated in a rat experiment.…”