Nonsteroidal Anti-Inflammatory Drugs: Gastroduodenal Injury and Beyond

There are numerous etiologic and pathogenic mechanisms associated with colitis, ranging from infectious to noninfectious colitis. However, despite their different causes, their presentations are often similar making it difficult to formulate the correct diagnosis. This article describes the presentation, endoscopic and pathological findings of six different noninfectious colitides: diversion colitis, neutropenic enterocolitis, disinfectant colitis, corrosive colitis, nonsteroidal anti-inflammatory drug and salicylate-induced colitis, and toxic epidermal necrolysis. In addition, this article discusses the management and current treatment options for these six colitides.

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“…Endoscopic findings range from patchy erythema and granularity to severe, extensive mucosal ulcers. 14…”

Section: Nonsteroidal Anti-inflammatory Drug and Salicylate-induced Cmentioning

confidence: 99%

Noninfectious Colitides

Quiogue

Bayasi

2015

Clinics in Colon and Rectal Surgery

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“…Exposure to NSAIDs may be anywhere from 2 days to 12 years, with a median of 3 months, prior to the development of symptoms. 108,109 Symptoms often resolve soon after the drug is discontinued. 110 Strictures of the colon may also form with NSAID use.…”

Section: Nsaidmentioning

confidence: 99%

Noninfectious Colitides: Collagenous Colitis, Lymphocytic Colitis, Diversion Colitis, and Chemically Induced Colitis

Thorsen

2007

Clinics in Colon and Rectal Surgery

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Approximately 10% of patients with chronic diarrhea carry a diagnosis of microscopic colitis. The endoscopic appearance of both collagenous colitis and lymphocytic colitis may be normal; however, biopsies confirm the diagnosis. Available treatments include antidiarrheals, bismuth salicylate, and budesonide. Although most patients with fecal diversion may have endoscopic evidence of colitis, a much smaller percentage of patients are symptomatic. Some cases of diversion colitis respond to treatment with shortchain fatty acid enemas; however, return of the fecal stream is the most successful therapy. A variety of oral, intravenous, and per rectum chemicals may cause colitis; symptoms usually abate when chemical exposure is discontinued. KEYWORDS: Collagenous colitis, lymphocytic colitis, microscopic colitis, diversion colitisObjectives: On completion of this article, the reader should be able to summarize the diagnostic work-up and available treatments for microscopic colitis. The reader will also be familiarized with diversion colitis and chemically induced colitis.

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“…Upper gastrointestinal complications of chronic NSAID use are well established, occurring in as much as 25% of patients. However, colonic ulceration and diaphragm disease has also become recognized as a major adverse event associated with NSAID use (2,3). Colonic diaphragms, though benign, can have serious patient implications such as intestinal obstruction and anaemia (3).…”

Section: Introductionmentioning

confidence: 99%

Colonic Diaphragm in a Patient with Rheumatoid Arthritis – A Case Report from the Caribbean

Felix¹,

Goodluck²,

Morant³

et al. 2015

West Indian Med J

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Colonic diaphragm is a rare complication of chronic use of non-steroidal anti-inflammatory drugs. Though benign, life-threatening complications such as intestinal obstruction and anaemia may ensue. Distinguishing colonic diaphragm from other causes of intestinal obstruction such as malignancy is often difficult, with patients often requiring surgical intervention to establish the diagnosis. We present a case of colonic diaphragm with a short review of the clinical and pathologic features.

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Nonsteroidal Anti-Inflammatory Drugs: Gastroduodenal Injury and Beyond

Cited by 5 publications

References 50 publications

Noninfectious Colitides

Noninfectious Colitides

Noninfectious Colitides: Collagenous Colitis, Lymphocytic Colitis, Diversion Colitis, and Chemically Induced Colitis

Colonic Diaphragm in a Patient with Rheumatoid Arthritis – A Case Report from the Caribbean

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