Nonrobertsonian translocation t(6;11) is associated with infertility in an oligoazoospermic male

Pernice, Francesco; Mazza, Giuseppa; Puglisi, Domenico; Luppino, Maria Giuseppa; Frisina, N

doi:10.1016/s0015-0282(02)03180-1

Cited by 16 publications

(15 citation statements)

References 5 publications

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“…The sex chromosomes are implicated in 3.8% of such abnormalities anomalies, while involve the sex chromosomes and 1.3% of abnormalities involve the autosomes (Bache et al, 2004). Most balanced chromosomal aberrations are not associated with a clinical phenotype; however, in some patients they may disrupt gene structure (Olesen et al, 2001;Pernice et al, 2002;Bianco et al, 2011;Li et al, 2014). Ananthapur et al (2014) reported the unusual non-Robertsonian translocation 46,XY,t(2;11)(p14;q21), found in an infertile oligozoospermic man with no clinical manifestations other than primary infertility.…”

Section: Discussionmentioning

confidence: 99%

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

Zhang¹,

Wang²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from northeastern China, and explored the relationship between sperm count and reproductive performance, to enable informed genetic counseling. The frequency of balanced reciprocal translocations was found to be 1.62%. Semen analysis showed that 5.9% of male carriers had azoospermia, 43.1% had oligozoospermia, and 51.0% had normozoospermia. Of the 25 men with a balanced reciprocal translocation and azoospermia or oligozoospermia, chromosome 1 was the most commonly often involved in the translocation. However, in the 26 normozoospermic men with a balanced reciprocal translocation and normozoospermia, chromosome 3 was most commonly implicated. Fifty percent of men with a balanced reciprocal translocation conceived a pregnancy that went to term. Our data suggest that of all chromosomes, Reciprocal translocations in northeastern Chinese men 18793©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18792-18798 (2015) chromosomes 1 and 3 are the most commonly involved chromosomes in balanced reciprocal such translocations in northeastern Chinese men. Karyotype analysis should be performed for men with azoospermia, oligozoospermia, and those in couples having suffered recurrent miscarriages. Natural conception should be discussed during genetic counseling for male carriers of balanced chromosomal translocations with normozoospermia.

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Section: Discussionmentioning

confidence: 99%

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

Zhang¹,

Wang²,

Li³

et al. 2015

Genet. Mol. Res.

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“…Alhough in men with oligozoospermia, frequent chromosome abnormalities are sex chromosome aberration and autosomal robertsonian translocation, the rate of reciprocal translocations is also higher than in normal individuals (1,4). The other reciprocal translocations reported in previous studies (3)(4)(5)(6)(7)(8) are shown in Table 1.…”

Section: Discussionmentioning

confidence: 84%

Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10)

Aydos

Tükün

2006

Fertility and Sterility

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“…Chromosome anomalies in males with oligozoospermia usually involve sex chromosomes and robertsonian translocations [6]; however, the rate of reciprocal translocations is also higher than in normal individuals [4]. The mechanism by which reciprocal translocations cause oligozoospermia is not completely clear.…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of chromosomal abnormalities in infertile males varies from 2.2% to 15.2% [3], among which robertsonian translocations and sex chromosome abnormalities are more frequent [4,5]. Reciprocal translocations have been found in only less than 1% of oligozoospermic men [6].…”

Section: Introductionmentioning

confidence: 99%

Impact of reciprocal translocation t (18; 21) on male infertility and embryo development: lessons from an oocyte-donating ICSI cycle

Zhang

Zhu

2011

J Assist Reprod Genet

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Purpose To report the outcome of intracytoplasmic sperm injection (ICSI) cycles of an oligozoospermic man with reciprocal translocation. Methods Two ICSI cycles were given to a 29-year-old man with severe oligozoospermia and reciprocal translocation t (18;21)(p11;q21) and his wife. In the first cycle, no sperm were found in his semen and all 15 oocytes retrieved were donated to another infertile couple suffering from oligozoospermia and premature ovarian failure. In the second cycle, sperm from the husband's ejaculate were used to fertilize 13 retrieved oocytes. Results Eleven embryos were acquired and a healthy girl was born in the oocyte-donated ICSI cycle. In the second cycle, 6 embryos were acquired and only biochemical pregnancy was achieved after three times of embryo transfer. Conclusions By the unusual oocyte-donating ICSI procedures, impact of the new reported reciprocal translocation t (18; 21) (p11; q21) on male fertility and embryo development was suggested.

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Nonrobertsonian translocation t(6;11) is associated with infertility in an oligoazoospermic male

Cited by 16 publications

References 5 publications

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10)

Impact of reciprocal translocation t (18; 21) on male infertility and embryo development: lessons from an oocyte-donating ICSI cycle

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