Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10)

Aydos, Sena; Tükün, Ajlan

doi:10.1016/j.fertnstert.2006.02.124

Cited by 11 publications

(10 citation statements)

References 7 publications

(9 reference statements)

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“…There are many case reports of male infertility due to balance translocation (Mark & Sigman, 1999;Quintana de la Rosa et al, 2001;Pernice et al, 2002;Aydos & Tukun, 2006). Here, we describe the case of a reciprocal balanced translocation t(8; 13) associated with male infertility.…”

Section: Discussionmentioning

confidence: 71%

Reciprocal balanced translocation: infertility and recurrent spontaneous abortions in a family

Goel

Phadke

2010

Andrologia

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In this case report we present a family with infertile, azoospermic but otherwise apparently healthy males with history of recurrent spontaneous abortions (RSA) in females. Karyotype of the infertile man revealed a reciprocal balanced translocation t(8; 13) with breakpoints at 8q22 and 13p11.2. The reported reciprocal balanced translocation is associated with azoospermia. The same translocation is probably the cause of RSA in females of the family.

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Section: Discussionmentioning

confidence: 71%

Reciprocal balanced translocation: infertility and recurrent spontaneous abortions in a family

Goel

Phadke

2010

Andrologia

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“…This may be due to disruption of critical genes involved in spermatogenesis or interference with chromosome segregation during meiosis [Foresta et al, 2001;Aydos and Tükün, 2006;Lehmann et al, 2012]. As impairment of testicular function seems to be limited to spermatogenesis, these cases should not be considered DSD.…”

Section: Discussionmentioning

confidence: 99%

A Search for Disorders of Sex Development among Infertile Men

Yabiku¹,

Guaragna²,

Sousa³

et al. 2018

Sex Dev

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A retrospective cross-sectional study was performed in a DSD clinic at a tertiary service (University Hospital) to estimate the frequency of disorders of sex development (DSD) among men who seek medical care because of infertility. The sample included 84 men >20 years of age referred from 2010-2017 due to oligozoospermia or nonobstructive azoospermia of unknown etiology. Twelve cases (14%) were diagnosed as DSD, including Klinefelter Syndrome, 46,XX testicular DSD, and mild androgen insensitivity syndrome. Y chromosome microdeletions were detected in 2 patients. Among the remaining 70 cases there were patients with chromosome abnormalities which are not included in the DSD classification as well as rare NR5A1 variants of uncertain significance and hypergonadotropic hypogonadism and microorchidism in 46,XY subjects. In conclusion, the frequency of DSD in this study was 14%, consisting mainly of sex chromosome abnormalities but also 46,XX and 46,XY DSD. However, this figure may increase as further investigations are conducted in idiopathic cases with signs of primary testicular failure, which may present partial gonadal dysgenesis.

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“…In a 46,XX,t(9;11)(p22;p15.5) case with different breakpoints from our case, the SRY gene was assigned to be positive, and delayed development and sex reversal were also observed (10) . Further, an infertile case with a 46,XY,t(9;15)(p10;q10) karyotype was defined (11) .…”

Section: Discussionmentioning

confidence: 99%

“…In various leukemia patients, t(9;11) cases with different break points were observed (18,19) . Infertility cases with balanced translocations of different chromosomes were also reported (4,6,11,20) . The common results of these gene was mapped in the 9p21-22 band region which was in the break point of our case (6) .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Familial Balanced Reciprocal Tranlocation t(9;11)(p12;p11.2) to Reproductive Performance

Ökten¹,

Kara²,

Tural³

et al. 2012

J Turk Soc Obstet Gynecol

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Aim: In this study, we report a couple who had been infertility problem for eight years and they had four failed IUI and one failed IVF. In second IVF attempt the women got pregnant and it resulted with abortion in eight week. Material and metods: Cytogenetic analysis was performed by standart peripheral blood culture and GTG method by using phytohemagglutinin-stimulated lymphocyte. Results: The women and her husband were phenotypically normal but karyotype analysis revealed 46, XX and 46,XY,t(9;11)(p12;p11.2) respectively. The mother of the husband's karyotype analysis showed the same translocation. The father of the husband's could not examined because he was not alive. Also two uncles of the husband were suffered from infertility for fifteen and five years respectively. However cytogenetic analyses of the uncles had not been accomplished yet. Balanced translocation carriers could give unbalanced chromosomes. Conclusion: The infertility cases of especially monosomy 9p and the other similar translocations that can result from the parents of balanced translocation carriers are represented here by comparing.

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Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10)

Cited by 11 publications

References 7 publications

Reciprocal balanced translocation: infertility and recurrent spontaneous abortions in a family

Reciprocal balanced translocation: infertility and recurrent spontaneous abortions in a family

A Search for Disorders of Sex Development among Infertile Men

The Effect of Familial Balanced Reciprocal Tranlocation t(9;11)(p12;p11.2) to Reproductive Performance

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