Nonpsychotic Psychiatric Disorders in Juvenile Myoclonic Epilepsy

Moskaleva, Polina; Шилкина, О. С.; Artyukhov, Ivan; Strotskaya, Irina G.; Дмитренко, Д. В.; Shnayder, N. А.

doi:10.21103/article7(2)_ra1

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Behavioral and mental disorders, especially unstable mood, anxiety, and personality disorders, are present on average in 30% of patients [48][49][50], in connection with which a number of authors figuratively call JME -"a wolf in sheep's clothing" (Fig. 7).…”

Section: Comorbid Disorders and Juvenile Myoclonic Epilepsymentioning

confidence: 99%

Juvenile myoclonic epilepsy: current state of the problem

Shnayder

Petrov

2021

jour

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Due to the high prevalence of the disease, its genetic and clinical heterogeneity, the need for lifelong therapy and the emergence of new views on the pathogenesis and course of JME, it is necessary to provide primary care physicians (general practitioners, district therapists, neurologists) with up-to-date systematized information about the most common form of genetic generalized epilepsy (Herpin-Janz syndrome). JME is a genetically determined disease of the brain, accompanied by a triad of seizures (absences, myoclonia, generalized tonic-clonic seizures), and developing mainly in adolescence and young age. In recent years, monogenic and multifactorial forms of JME have been identified, but questions about the genetics of JME are far from being resolved. JME is characterized by the preservation of intelligence, life expectancy with adequate therapy does not differ from the average population, but the frequency of failures of pharmaco-induced remission is high when taking anticonvulsants is canceled. This explains the need for lifelong pharmacotherapy, individual selection of anticonvulsants. About 30% of patients with JME have non-psychotic mental disorders, disorders of the sleep and wake cycle, which in turn leads to an aggravation of epileptic seizures mainly in the first half of the day. This review presents an analysis of full-text publications in Russian and English over the past five years in the databases eLibrary, PubMed, Web of Science, OxfordPress, Springer, and Clinicalkeys. In addition, the review includes earlier publications of historical significance.

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Section: Comorbid Disorders and Juvenile Myoclonic Epilepsymentioning

confidence: 99%

Juvenile myoclonic epilepsy: current state of the problem

Shnayder

Petrov

2021

jour

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“…Moskaleva et al previously described this vicious cycle: "Despite recognizing the factors, which cause more frequent seizures and worsening of the general condition, many patients cannot cope with their emotions singly; they note a decrease in stress resistance, and therefore complain about the difficulties of falling asleep, resulting in an undesirable lack of sleep." (32) Depression forms pathophysiological pathways with the epileptogenic process and may be independent of seizure control. S.Roshan tried to attribute this connection.…”

Section: Comorbid Depression and Anxietymentioning

confidence: 99%

Advances in the Management of Sleep Disorders in Juvenile Myoclonic Epilepsy

Moskaleva¹,

Шилкина²,

Shnayder³

et al. 2018

IJBM

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Juvenile myoclonic epilepsy (JME) is a well-defined sub-syndrome of idiopathic generalized/genetic epilepsy, usually presenting in adolescence and characterized by myoclonic jerks, predominately in the arms, associated with tonic-clonic seizures and less often generalized absences. Although the evidence base for a relationship between JME and sleep disorders is weak, most experts regard sleep disorders as an actual comorbidity. This paper reviews the literature underpinning the development of sleep disorders in JME patients. Data that report associated causes of sleep problems in JME patients are discussed, as is the importance of counseling on lifestyle issues. Lastly, a practical approach to managing sleep disorders in young men and women with JME is summarized. (International Journal of Biomedicine. 2018;8(2):108-114.)

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“…Dysfunction of frontal lobe, which is responsible for decisionmaking, individuality, motion and speech, was demonstrated in patients with JME [4]. Tapping is known as a psychomotor test for evaluation of brain psychophysiological functions, such as time perception [5].…”

Section: Introductionmentioning

confidence: 99%

Influence of anxiety on wrist tapping parameters and individual perception of one minute in healthy adults and in patients with juvenile myoclonic epilepsy

Narodova¹,

Shnayder²,

Narodova³

et al. 2018

Russ Open Med J

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Aim -To study the influence of anxiety on parameters of wrist tapping in normal conditions and in juvenile myoclonic epilepsy (JME). Material and Methods -We evaluated 105 people aged 16 to 55 years old (average: 31.6±10.2 years). The sample was comprised of two groups: first (I) group -healthy volunteers (n=60); second (II) group -patients with JME (n=45). Every group was stratified into two subgroups: subgroup Ia (n=33) -healthy volunteers without symptoms of anxiety; subgroup Ib (n=27) -healthy volunteers with subclinical anxiety; subgroup IIa (n=19) -patients with JME without symptoms of anxiety; subgroup IIb (n=26) -patients with JME with subclinical anxiety. Wrist tapping parameters were studied using method of our authorship named «Method of influencing a person's individual rhythm through exogenous rhythmic stimulation». We studied reference ranges of basic characteristics of wrist tapping. Results -Comparison of basic parameters of wrist tapping in subgroups Ia and IIa revealed a trend towards an increase in rhythm stability in patients with JME when compared to healthy volunteers. At the same time, subclinical anxiety led to a pronounced increase in frequency of individual rhythm in subgroup IIb when compared to subgroup Ia. Conclusion -Influence of anxiety on wrist tapping parameters is more pronounced in patients with JME when compared to healthy volunteers.

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Nonpsychotic Psychiatric Disorders in Juvenile Myoclonic Epilepsy

Cited by 5 publications

References 28 publications

Juvenile myoclonic epilepsy: current state of the problem

Juvenile myoclonic epilepsy: current state of the problem

Advances in the Management of Sleep Disorders in Juvenile Myoclonic Epilepsy

Influence of anxiety on wrist tapping parameters and individual perception of one minute in healthy adults and in patients with juvenile myoclonic epilepsy

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