Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice: In Vitro and In Vivo Studies

“…In contrast, both dose regimes diminished the total adenoma volume significantly by ≈55% without affecting adenoma number in female mice (Figure ). The histopathological analysis verified the nodular lesions in the intestine of selected animals as being intestinal adenomas according to current guidelines . While the macroscopically determined parameters (i.e., adenoma number and volume) markedly differ between groups, microscopical assessment of gut samples did not show significant differences between study groups regarding cellular pleomorphism, atypia, dysplasia, nuclear morphology, or growth pattern.…”

4-Methylthio-3-butenyl isothiocyanate (raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats

“…Tissue slices of all organs were routinely processed for paraffin embedding, and sections were prepared and stained with hematoxylin and eosin (HE) for histopathological evaluation. Esophageal lesions were classified into hyperplasia, atypical hyperplasia (i.e., dysplasia), papilloma, and carcinoma of squamous cells based on histopathological features in rats, in accordance with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) 25 . Diagnostic features are as follows.…”

The Histopathological Effect of Rotavirus in Small Intestine of Mice Isolated from Different Area of Iraq

“…Group A rotaviruses have been shown to induce biliary atresia in mice, but this system requires intraperitoneal not oral inoculation of virus [16]. The most detailed studies of extra intestinal spread in the mouse examined spread to the liver following oral inoculation [8,17].…”