Nonoperative Treatment of Dupuytren’s Disease

Hurst, Lawrence C.; Badalamente, Marie A.

doi:10.1016/s0749-0712(21)00443-1

Cited by 93 publications

(13 citation statements)

References 34 publications

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“…Forty-four patients (77%) treated had no disease progression but 13 (23%) did progress. Another study of radiotherapy treatment, with a 7-year follow-up, reported no difference between the treated group and the untreated one (Hurst and Badalamente, 1999). Today, radiotherapy is not commonly used for benign diseases because of its side effects, such as lymphatic occlusions, actinic nerve lesions, with reduction of motor strength and sensory reinnervation, and various skin changes, such as radiodermatitis, sclerosis of the dermis, friable nails, ulceration and necrosis (Brenner and Rayan, 2003).…”

Section: Alternatives To Surgerymentioning

confidence: 98%

“…For the treatment and prevention of Dupuytren's contracture, some researchers in the past had turned their attention to the possible clinical-therapeutic role of allopurinol (Murrel et al, 1987), which inhibits xanthine oxidase and prevents free radical formation. However, experimental studies have shown that this role is absolutely insignificant (Hurst and Badalamente, 1999).…”

Section: (G) Free Radicalsmentioning

confidence: 99%

“…The existence of cases with regression and complete spontaneous healing without any surgical treatment has led to a search for possible alternatives to surgery, such as the use of creams based on vitamin E, dimetilsulphoxides, drugs inducing hypo-uricaemia and therapy with ultrasounds (Hurst and Badalamente, 1999). However, many of these therapies have not led to any clinical improvement and have not made it possible to stabilize the disease in the long term.…”

Section: Alternatives To Surgerymentioning

confidence: 99%

“…In the ensuing 4 months, he, or she, then has to do exercises to restore flexion and extension and, at night, wear an extension splint. In this way, fair results are achieved in over 90% of contractures of the metacarpophalangeal joint and in over 66% of contractures of the proximal interphalangeal joint (Hurst and Badalamente, 1999). At present, no longterm results with this type of treatment are known.…”

Section: Alternatives To Surgerymentioning

confidence: 99%

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Dupuytren’s Contracture: An Update of Biomolecular Aspects and Therapeutic Perspectives

Cordova

Tripoli

Corradino

et al. 2005

Journal of Hand Surgery

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The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.

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Section: Alternatives To Surgerymentioning

confidence: 98%

Section: (G) Free Radicalsmentioning

confidence: 99%

Section: Alternatives To Surgerymentioning

confidence: 99%

Section: Alternatives To Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Dupuytren’s Contracture: An Update of Biomolecular Aspects and Therapeutic Perspectives

Cordova

Tripoli

Corradino

et al. 2005

Journal of Hand Surgery

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“…A large portion of these treatments have no longer confirmed or demonstrated to be clinically valuable. After all, Shockwave treatment has shown empowering results [3]. Finding is typically based on signs and symptoms; Patients, at first, may be symptomless and they may introduce withdrawal of palmar facia related with nodules, at a later stage their capacity to hold and maintain items plus ache and pain logically decline [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of extracorporeal shockwave therapy on palmar fibromatosis

Saad¹,

Elbaky²,

Alfotooh³

et al. 2021

jlsb

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Introduction. Extracorporeal shock wave therapy (ESWT) is therapeutic modality that applies shockwave from outer part of the body to a specific lesion and promotes revascularization and hence stimulates the curing process of connective tissues, relieves pain and improves function. Aim. The present study was done to detect the role of extracorporeal shock wave therapy in reducing palmar fibromatosis using Arabic version of modified QuickDASH-9 scale. Methods. Thirty patient with age ranged from 50 to 70 suffering from palmar fibromatosis were randomly selected from faculty of physical therapy modern technology and information university outpatient hand clinic, Cairo, Egypt and distributed into two equal groups: study group (A) received ESWT once a week for six weeks, done at frequency of 6-8 Hz with 1700 pulse/session at 0.18 mj/cm2 with traditional physical therapy protocol (U.S, massage, stretching ex, range of motion (ROM) ex and splinting). Group B received traditional physical therapy protocol. The measurements were conducted pre and post six weeks of treatment using Arabic version of Modified Quick DASH-9 scale and Jamar hand dynamometer. The study was carried out from April to December 2020. Descriptive statistics and unpaired t-test were conducted for comparison of age between groups. Results. There was a significant decrease in the score of Arabic modified Quick DASH scoring which is a good sign of improvement and increase in the hand grip strength. Conclusion. Extracorporeal shockwave is a beneficial method in reducing the progress of palmar fibromatosis.

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Acquired Disorders of Dermal Connective Tissue

Lovell

2016

Rook's Textbook of Dermatology, Ninth Edition

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The subject matter of this chapter comprises the major acquired disorders that affect mainly collagen and elastic tissue. The connective tissue of normal skin is discussed elsewhere. Heritable disorders of connective tissue, such as Ehlers–Danlos syndrome, are covered in another chapter, as are disorders of ground substance, such as the mucinoses and mucopolysaccharidoses. In addition, many disorders, including developmental defects, neoplasms and other reactive or scarring conditions, may involve the connective tissues. Although it can be convenient to separate conditions into disorders affecting collagen or elastic tissue, the distinction is somewhat artificial, as changes in these proteins are generally preceded by abnormal metabolism of other matrix components, such as fibronectin or periostin.

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Nonoperative Treatment of Dupuytren’s Disease

Cited by 93 publications

References 34 publications

Dupuytren’s Contracture: An Update of Biomolecular Aspects and Therapeutic Perspectives

Dupuytren’s Contracture: An Update of Biomolecular Aspects and Therapeutic Perspectives

Effect of extracorporeal shockwave therapy on palmar fibromatosis

Acquired Disorders of Dermal Connective Tissue

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