Nonmyogenic Cells in Skeletal Muscle Regeneration

Paylor, Ben; Natarajan, Arunkumar; Zhang, Regan-Heng; Rossi, Fábio

doi:10.1016/b978-0-12-385940-2.00006-1

Cited by 43 publications

(35 citation statements)

References 124 publications

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“…Moreover, Paylor et al (2001) reported that non-myogenic cell populations are likely present in newt myofiber interstitium, and might participate in skeletal muscle regeneration (Paylor et al, 2011). Axolotl limbs harbor a Pax7 þ satellite cell population and proliferative Pax7 þ cells are observed during limb regeneration (Kragl et al, 2009).…”

Section: Amphibiansmentioning

confidence: 98%

Regeneration across Metazoan Phylogeny: Lessons from Model Organisms

Yang

Zhong

2015

Journal of Genetics and Genomics

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Section: Amphibiansmentioning

confidence: 98%

Regeneration across Metazoan Phylogeny: Lessons from Model Organisms

Yang

Zhong

2015

Journal of Genetics and Genomics

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“…Such ability is mostly dependent on myogenic precursor cells. Among these cells, particularly relevant are the satellite cells (SC), which are located under the basal lamina of myofibres, although other interstitial stem cells may also play a role [41]. SC activate and differentiate upon muscle injury contributing significantly to its repair.…”

Section: Nitric Oxide In Myogenesis and Skeletal Muscle Repairmentioning

confidence: 99%

Nitric Oxide in Myogenesis and Therapeutic Muscle Repair

Palma

Clementi

2012

Mol Neurobiol

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Nitric oxide is a short-lived intracellular and intercellular messenger. The first realisation that nitric oxide is important in physiology occurred in 1987 when its identity with the endothelium-derived relaxing factor was discovered. Subsequent studies have shown that nitric oxide possesses a number of physiological functions that are essential not only to vascular homeostasis but also to neurotransmission, such as in the processes of learning and memory and endocrine gland regulation, as well as inflammation and immune responses. The discovery in 1995 that a splice variant of the neuronal nitric oxide synthase is localised at the sarcolemma via the dystrophin-glycoprotein complex and of its displacement in Duchenne muscular dystrophy has stimulated a host of studies exploring the role of nitric oxide in skeletal muscle physiology. Recently, nitric oxide has emerged as a relevant messenger also of myogenesis that it regulates at several key steps, especially when the process is stimulated for muscle repair following acute and chronic muscle injuries. Here, we will review briefly the mechanisms and functions of nitric oxide in skeletal muscle and discuss its role in myogenesis, with specific attention to the promising nitric oxide-based approaches now being explored at the pre-clinical and clinical level for the therapy of muscular dystrophy.

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“…Until now, scholars have carried out a lot of empirical studies on this topic, and some measures to stop the process of denerved muscle atrophy have been raised, such as the application of clenbuterol, electric stimulation, Chinese drugs, and nerve homogenate and neuron implantation; although all these measures can relieve atrophy partially, none of them can address the problem of atrophic muscle functional recovery fundamentally (Bischoff & Heintz, 1994;Hall et al, 2011;Paylor et al, 2011;Sharifiaghdas et al, 2011;YablonkaReuveni, 2011). With the rise of study on embryonic stem cells and adult stem cells in recent years, more and more scholars have realized that muscle satellite cells (SCs) play an important role in atrophic muscle regeneration, and SCs have been more and more extensively accepted as muscle adult stem cells (Schmalbruch & Lewis, 1994).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells

Sun

Zhu

et al. 2012

Int. J. Morphol.

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SUMMARY:In order to explore the change rule of myoblast stem cells (satellite cells, SCs) in the denervated and re-innervated muscle and to investigate the cellular mechanism of the morphological and functional changes of the muscle, denervated muscle atrophy and nerve regeneration models were established in one-month-old rats. Postoperative indexes such as muscle wet weight, cell section areas, content of collagen fibers and DNA, electrophysiology, numbers of SCs in the triceps muscle of calf were dynamically tested. After denervation, the muscle wet weight and cell area reduced rapidly, and the collagen fiber content increased slowly. The number of SCs increased at first, and then declined suddenly two months later. From 4 to 5 weeks after re-neuralization, muscle action potentials could be evoked, but the best innervation effect was found in the groups, which received re-neuralization at 2 months and 3 months after denervation. Denervation causes a progressive progress of muscle atrophy. SCs proliferate within 3 months after denervation, and then atrophy becomes irreversible from 4 months. At 4 or 5 weeks after re-neuralization, muscle action potentials can be evoked. Re-neuralization at 2 months and 3 months after denervation can achieve a good effect on the functional recovery of the atrophic muscle.

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Nonmyogenic Cells in Skeletal Muscle Regeneration

Cited by 43 publications

References 124 publications

Regeneration across Metazoan Phylogeny: Lessons from Model Organisms

Regeneration across Metazoan Phylogeny: Lessons from Model Organisms

Nitric Oxide in Myogenesis and Therapeutic Muscle Repair

Correlation between Innervation of Skeletal Muscles and Myoblast Stem Cells

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