Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap)

Neubauer, Aljoscha S.; Kernt, Marcus; Haritoglou, Christos; Priglinger, Siegfried; Kampik, Anselm; Ulbig, Michael W.

doi:10.1007/s00417-007-0631-4

Cited by 80 publications

(73 citation statements)

References 19 publications

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“…Effective axial line rate with 6x averaging is 1.1 MHz, still higher than the raw speed demonstrated with any non-FMDL light source. The en-face image also shows ciliary shadowing, a typical problem encountered in wide-field retinal imaging [78].…”

Section: 7 Mhz Dual-spot Imaging: Fdml Without Dispersion Compensationmentioning

confidence: 92%

Multi-MHz retinal OCT

Klein

Wieser

Reznicek

et al. 2013

Biomed. Opt. Express

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Abstract:We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging of the human retina at A-scan rates in excess of 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line rates are investigated, and a simple multi-volume data processing approach is presented. In-vivo OCT of the human ocular fundus is performed at different axial scan rates of up to 6.7 MHz. High quality non-mydriatic retinal imaging over an ultra-wide field is achieved by a combination of several key improvements compared to previous setups. For the FDML laser, long coherence lengths and 72 nm wavelength tuning range are achieved using a chirped fiber Bragg grating in a laser cavity at 419.1 kHz fundamental tuning rate. Very large data sets can be acquired with sustained data transfer from the data acquisition card to host computer memory, enabling high-quality averaging of many frames and of multiple aligned data sets. Three imaging modes are investigated: Alignment and averaging of 24 data sets at 1.68 MHz axial line rate, ultra-dense transverse sampling at 3.35 MHz line rate, and dual-beam imaging with two laser spots on the retina at an effective line rate of 6.7 MHz. 58. R. Huber, D. C. Adler, V. J. Srinivasan, and J. G. Fujimoto, "Fourier domain mode locking at 1050 nm for ultrahigh-speed optical coherence tomography of the human retina at 236,000 axial scans per second," Opt. Lett. ©2013 Optical Society of America

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Section: 7 Mhz Dual-spot Imaging: Fdml Without Dispersion Compensationmentioning

confidence: 92%

Multi-MHz retinal OCT

Klein

Wieser

Reznicek

et al. 2013

Biomed. Opt. Express

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198

124

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“…7 Our first observation was that although all ultra wide-angle images were gradable, there were nine conventional images that fell short of grading standards, predominantly due to media opacities and technical difficulties with positioning the patient for long enough to take gradable images. As lasers are much less susceptible to any media opacities 18,19 and they outperform even very high resolution digital images in terms of sharpness and contrast, 20 the better image quality is perhaps not surprising. However, it must be acknowledged that new graders must learn to appreciate artifacts related to the broad depth of focus of this device, such as the presence of eyelids, eyelashes, floaters (eg, see Supplementary Figure 1), the optics and the haptics of the intraocular lens or lens opacities.…”

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confidence: 99%

Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study

Csutak

Lengyel

Jónasson

et al. 2010

Eye

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Purpose To establish the agreement between image grading of conventional (451) and ultra wide-angle (2001) digital images in the macula. Methods In 2008, the 12-year follow-up was conducted on 573 participants of the Reykjavik Eye Study. This study included the use of the Optos P200C AF ultra wide-angle laser scanning ophthalmoscope alongside Zeiss FF 450 conventional digital fundus camera on 121 eyes with or without age-related macular degeneration using the International Classification System. Of these eyes, detailed grading was carried out on five cases each with hard drusen, geographic atrophy and chorioretinal neovascularisation, and six cases of soft drusen. Exact agreement and j-statistics were calculated. Results Comparison of the conventional and ultra wide-angle images in the macula showed an overall 96.43% agreement (j ¼ 0.93) with no disagreement at end-stage disease; although in one eye chorioretinal neovascularisation was graded as drusenoid pigment epithelial detachment. Of patients with drusen only, the exact agreement was 96.1%. The detailed grading showed no clinically significant disagreement between the conventional 451 and 2001 images. Conclusions On the basis of our results, there is a good agreement between grading conventional and ultra wide-angle images in the macula.

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“…The potential for use of UWF imaging, particularly UWF FA, for enhancing diagnosis and treatment in DR has been demonstrated [23]. Several studies compared UWF pseudocolor images with conventional fundus photographs in the screening of DR [24][25][26][27]. Wilson et al [26] reported 83.6% sensitivity for UWF images versus 82.9% for digital photography in identifying DR. Silva et al [25] found that UWF matched 7 standard grading of severity in 80% of eyes and was within 1 level in 94.5% of eyes.…”

Section: Clinical Applications Of Ultra-widefield Imaging Diabetic Rementioning

confidence: 99%

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

Lee

Sagong

2016

J Retin

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The peripheral retina is frequently affected by various diseases and ultra-widefield (UWF) imaging has become an essential tool for evaluation of peripheral retinal pathology. The wide angle and high resolution of this imaging device were recently updated along with multimodal capabilities, including pseudocolor fundus photographs, fluorescein and indocyanine green angiography, and autofluorescence images. Using this UWF technology, important clinical observations have been made in the normal population and patients with certain diseases including diabetic retinopathy, retinal vascular occlusion, retinal detachment, uveitis, age-related macular degeneration, and choroidal tumors. Although peripheral distortion and the need for clinical validation are obstacles to overcome for the accurate quantification and more generalized use, UWF imaging has provided new insights into a variety of disorders and has become the standard-ofcare imaging modality for many diseases. Therefore, use of UWF retinal imaging for the daily retina practice in the near future is inevitable. This review will describe the principles of UWF technologies with several modalities, and include its clinical applications and then suggest future directions.

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Nonmydriatic screening for diabetic retinopathy by ultra-widefield scanning laser ophthalmoscopy (Optomap)

Abstract: The Optomap Panoramic200 nonmydriatic images are of sufficient quality to assess DR and CSME validly and therefore fulfill the basic requirements for telescreening programs.

Cited by 80 publications

References 19 publications

Multi-MHz retinal OCT

Multi-MHz retinal OCT

Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study

Ultra-Widefield Retina Imaging: Principles of Technology and Clinical Applications

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