Nonmonotonic age changes in susceptibility to hypothermia-induced retrograde amnesia in rats

Mactutus, Charles F.; Concannon, James T.; Riccio, David C.

doi:10.1016/0031-9384(82)90218-9

Cited by 19 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the reminder was just as effective in overcoming hypothermia-induced amnesia as it was in overcoming normal memory impairment (Experiment 1). These results contrast sharply with those reported by Mactutus et al (1982) and Richardson and Riccio (1987), who found no evidence of hypothermia-induced retrograde amnesia in 23-day-old rats. We believe the discrepancy between our results and those reported by them may be due to subtle procedural differences.…”

Section: Discussioncontrasting

confidence: 99%

Preventing and alleviating hypothermia-induced amnesia in weanling and young adult rats.

Hinderliter¹,

Blanton²,

Misanin³

1989

Behavioral Neuroscience

View full text Add to dashboard Cite

Reminder (Experiment 1) and familiarization (Experiment 2) treatments were found to have similar effects on the 24-hr retention performance of 24- to 26- and 90- to 100-day-old rats that either did or did not undergo an amnesic treatment (hypothermia) immediately after training. Similar degrees of retrograde amnesia and normal forgetting were evident in both trained age groups that were not subjected to familiarization or reminder treatments. These results suggest that memory processes in weanling and adult rats are similar in susceptibility to disruption by an established amnesic treatment (hypothermia) and in the ease of prevention of and recovery from amnesia by recognized preventive (familiarization) and alleviation (reminder) measures. The similarity of the effects of these preventive and alleviation treatments on normal forgetting and induced amnesia suggests that experimentally induced amnesia may be a fruitful approach to studying the ontogeny of memory processes and, more specifically, to studying factors that influence infantile amnesia.

show abstract

Section: Discussioncontrasting

confidence: 99%

Preventing and alleviating hypothermia-induced amnesia in weanling and young adult rats.

Hinderliter¹,

Blanton²,

Misanin³

1989

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…In addition, others reported that the amnesia following reactivation was only transient [69]. Nevertheless, a number of studies confirmed the initial findings of Misanin et al [68] using different memory tasks and amnesic agents, including hypothermia and protein synthesis inhibitors [71,74,75]. A basic model that came from these experiments was that it is not the time elapsed since encoding that determines the susceptibility of the memory trace, but the functional state of the trace itself.…”

Section: Introductionmentioning

confidence: 55%

Memory

Alberini

Milekic

Tronel

2006

Cell. Mol. Life Sci.

136

View full text Add to dashboard Cite

Memories become stabilized through a time-dependent process that requires gene expression and is commonly known as consolidation. During this time, memories are labile and can be disrupted by a number of interfering events, including electroconvulsive shock, trauma and other learning or the transient effect of drugs such as protein synthesis inhibitors. Once consolidated, memories are insensitive to these disruptions. However, they can again become fragile if recalled or reactivated. Reactivation creates another time-dependent process, known as reconsolidation, during which the memory is restabilized. Here we discuss some of the questions currently debated in the field of memory consolidation and reconsolidation, the molecular and anatomical requirements for both processes and, finally, their functional relationship.

show abstract

“…Several other findings that seem inconsistent with the consolidation view may in fact be compatible with that state dependent interpretation. For instance, it has been noted that several factors, including a strong training reinforcer, overtraining, pre-exposure to the conditioning context, or weak amnestic treatments, can reduce the susceptibility to retrograde amnesia (Geller et al, 1970; Miller, 1970; Mactutus et al, 1982; Parent and McGaugh, 1994; Garín-Aguilar et al, 2014). We suggest that when the information acquired during initial training is unusually strong, due to the use of numerous training trials or of a strong reinforcer, the internal state produced by the amnestic agent is less salient than the training state.…”

Section: State Dependency To Explain Retrograde Amnesiamentioning

confidence: 99%

Memory Integration as a Challenge to the Consolidation/Reconsolidation Hypothesis: Similarities, Differences and Perspectives

Gisquet-Verrier

Riccio

2019

Front. Syst. Neurosci.

Self Cite

View full text Add to dashboard Cite

We recently proposed that retrograde amnesia does not result from a disruption of the consolidation/reconsolidation processes but rather to the integration of the internal state induced by the amnesic treatment within the initial memory. Accordingly, the performance disruption induced by an amnesic agent does not result from a disruption of the memory fixation process, but from a difference in the internal state present during the learning phase (or reactivation) and at the later retention test: a case of state-dependency. In the present article, we will review similarities and differences these two competing views may have on memory processing. We will also consider the consequences the integration concept may have on the way memory is built, maintained and retrieved, as well as future research perspectives that such a new view may generate.

show abstract

Nonmonotonic age changes in susceptibility to hypothermia-induced retrograde amnesia in rats

Cited by 19 publications

References 30 publications

Preventing and alleviating hypothermia-induced amnesia in weanling and young adult rats.

Preventing and alleviating hypothermia-induced amnesia in weanling and young adult rats.

Memory

Memory Integration as a Challenge to the Consolidation/Reconsolidation Hypothesis: Similarities, Differences and Perspectives

Contact Info

Product

Resources

About