Nonmelanoma skin cancer in the United States: Incidence

Miller, Dena L.; Weinstock, Martin A.

doi:10.1016/s0190-9622(08)81509-5

Cited by 1,028 publications

(709 citation statements)

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“…It has been established that UVB-induced oxidative stress contributes to several adverse biologic effects including skin cancers and premature aging of the skin in an in vivo system [11,36,37]. We observed that chronic exposure to UVB radiation induced higher levels of oxidative stress in the skin of obese mice than wild-type mice when measured in terms of depletion of antioxidant defense enzymes, such as GSH, GPx and catalase, and generation of H 2 O 2 and nitric oxide.…”

Section: Discussionmentioning

confidence: 76%

Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-κB signaling

Katiyar

Meeran

2007

Free Radical Biology and Medicine

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Obesity has been implicated in several diseases including cancer, however, the relationship of obesity and susceptibility to ultraviolet (UV) radiation-caused skin diseases has not been investigated. As UV-induced oxidative stress has been implicated in several skin diseases, we assessed the role of obesity on UVB-induced oxidative stress in genetically obese Lep ob /Lep ob (leptin-deficient) mice. Here, we report that chronic exposure to UVB (120 mJ/cm 2 ) resulted in greater oxidative stress in the skin of obese mice in terms of higher levels of H 2 O 2 and NO production, photo-oxidative damage of lipids and proteins, and greater depletion of antioxidant defense enzymes, like, glutathione, glutathione peroxidase and catalase. As UV-induced oxidative stress mediates activation of MAPK and NF-κB signaling pathways, we determined the effect of UVB on these pathways in obese mice. Exposure of obese mice to UVB resulted in phosphorylation of ERK1/2, JNK and p38 proteins of the MAPK family. Compared to wild-type mice, the obese mice exhibited higher levels of phosphorylation of these proteins, greater activation of NF-κB/p65, and higher levels of circulating proinflammatory cytokines, including TNF-α, IL-1-β and IL-6, on UVB irradiation. Together, our study suggests for the first time that obesity in mice is associated with greater susceptibility to UVBinduced oxidative stress, and therefore may be a risk factor for skin diseases associated with UVBinduced oxidative stress.

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Section: Discussionmentioning

confidence: 76%

Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-κB signaling

Katiyar

Meeran

2007

Free Radical Biology and Medicine

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“…[2][3][4] After a rise in incidence of roughly 20% between 1971 and 1977, 5 by 1998 roughly one million new cases were being diagnosed annually in the United States. 6 In consequence of its high incidence, BCC, although eminently curable when the diagnosis is made promptly and the lesion treated in its early phase, constitutes an enormous financial burden on the health care system.…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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“…1 Although metastases rarely occur, the tumor cells are locally invasive, destroy surrounding tissue and cause substantial morbidity. Cell-mediated immunity appears to be important in the pathogenesis of BCC and the immune system may contribute to protection in this disease.…”

Section: Introductionmentioning

confidence: 99%