Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy

Chen, Jiping; Ruczinski, Ingo; Jorgensen, Timothy J.; Yenokyan, Gayane; Yao, Yin; Alani, Rhoda M.; Liégeois, Nanette J.; Hoffman, Sandra C.; Hoffman‐Bolton, Judith; Strickland, Paul T.; Helzlsouer, Kathy J.; Alberg, Anthony J.

doi:10.1093/jnci/djn260

Cited by 103 publications

(88 citation statements)

References 28 publications

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“…reports, except that the risk estimate tended to be lower in the present study (multivariable-adjusted HR ¼ 2.22) than those reported in previous case-control or registry-based studies (HR/ meta-analysis relative risk > 2.70) (6)(7)(8) and in a prospective study with a total of 19 174 individuals and a 16-year follow-up (multivariable-adjusted relative risk ¼ 7.94) (9). The modest associations reported in our study may be partly explained by the adjustment for a number of potential risk factors.…”

Section: Articlecontrasting

confidence: 88%

“…Our previous study has reported an increased risk of cancer including melanoma in association with history of KC in the Nurses' Health Study (NHS;1984-2008 and Health Professionals Follow-up Study (HPFS;1986-2008 (18). However, this previous report did not examine the detailed subgroups of KC in association with the risk of developing melanoma and melanoma subtypes, did not investigate the impact of multiple KCs on melanoma risk, and did not investigate the potential modification of the KC-melanoma association by other melanoma risk factors.…”

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confidence: 99%

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History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Cho

et al. 2017

JNCI: Journal of the National Cancer Institute

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Background: The association between history of keratinocyte carcinoma (KC, also known as nonmelanoma skin cancer) and risk of developing invasive melanoma has not been assessed comprehensively using prospective data. Methods: We followed 91 846 women in the Nurses' Health Study (NHS; 1984-2010, 114 918 women in the NHSII , and 48 946 men in the Health Professionals Follow-up Study (1986-2010 for diagnoses of KC and melanoma biennially. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma associated with history of KC, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). All statistical tests were two-sided. Results: We documented 1949 melanomas, 38 842 BCCs, and 7462 SCCs over 6.4 million person-years of follow-up. After adjustment for other risk factors, a personal history of KC was associated with an increased risk of melanoma (meta-analysis HR ¼ 2.22, 95% CI ¼ 1.73 to 2.85). The association was more apparent among participants with a history of both BCC and SCC (HR ¼ 3.40, 95% CI ¼ 1.60 to 7.19) than among participants with a history of BCC only (HR ¼ 2.20, 95% CI ¼ 1.80 to 2.70) or SCC only (HR ¼ 1.56, 95% CI ¼ 0.98 to 2.46), and there was a strong risk-increasing trend associated with a higher number of reported KCs removed by surgery (P trend < .001). In women, KC history was more strongly associated with head/neck melanomas (HR ¼ 4.17, 95% CI ¼ 2.77 to 6.27) than with trunk or limb melanomas (both HRs < 2.50, P heterogeneity ¼ .04). Conclusions: Our results provide novel insights for the relationship between KC history and risk of developing melanoma, which may be important for melanoma prevention.

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Section: Articlecontrasting

confidence: 88%

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confidence: 99%

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Cho

et al. 2017

JNCI: Journal of the National Cancer Institute

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“…[116][117][118][119]123,[125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140][141] …”

Section: Follow-up and Reducing Risk For Future Skin Cancersunclassified

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

314

219

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Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed. ( J Am Acad Dermatol

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“…Furthermore, a recent study showed that individuals with a history of NMSC may be at a greater risk of going on to develop other types of cancer. 9 The principal cause of skin cancer is excessive exposure to ultraviolet radiation (UVR), solar radiation being the principal source. Other risk factors that appear to be involved with the development of NMSC include mutations in regulatory genes, exposure to ionizing radiation, arsenic, polyaromatic hydrocarbons and changes in the immune system, among others.…”

Section: Introductionmentioning

confidence: 99%

Estimativa do custo do tratamento do câncer de pele tipo não-melanoma no Estado de São Paulo - Brasil

Souza

Mattedi

Correa

et al. 2011

An. Bras. Dermatol.

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FUNDAMENTOS: O câncer de maior incidência no Brasil é o de pele não-melanoma, que afeta aproximadamente 0,06% da população. Não existem políticas públicas para sua prevenção e o impacto econômico do seu diagnóstico não tem sido avaliado. OBJETIVOS: Estimar os custos do diagnóstico e tratamento do câncer de pele não-melanoma no Estado de São Paulo entre 2000 a 2007 e compará-los com os do melanoma cutâneo no mesmo período. MÉTODOS: Foi utilizado como modelo de procedimento o projeto diretriz Clinical Practice Guidelines in Oncology, (National Comprehensive Cancer Network), adequado aos procedimentos da Fundação SOBECCan - Hospital do Câncer de Ribeirão Preto - SP. Os custos estimados baseiam-se nos valores do tratamento médico pagos pelos setores público e privado em 2007. RESULTADOS: Os valores médios de custo individual do tratamento anual do câncer de pele não-melanoma são muito mais baixos do que os estimados para o tratamento do melanoma cutâneo. Entretanto, observados os gastos totais no tratamento do câncer de pele não-melanoma, percebe-se que os 42.184 casos deste câncer em São Paulo, no período estudado, fazem com que o custo total do seu tratamento seja 14% superior ao dos 2.740 casos de melanoma cutâneo registrados no mesmo período para o SUS. Porém, para o sistema privado, o gasto total é, aproximadamente, 34% menor para o tratamento do câncer de pele não-melanoma. CONCLUSÃO: O elevado número de casos de câncer de pele não-melanoma no Brasil - com 114 mil novos casos previstos para 2010, sendo 95% diagnosticados em estágios precoces - representa um impacto financeiro ao sistema público e aos sistemas privados de saúde de cerca de R$ 37 milhões e R$ 26 milhões ao ano, respectivamente

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Nonmelanoma Skin Cancer and Risk for Subsequent Malignancy

Abstract: This community-based, prospective cohort study provides evidence for an association between an NMSC diagnosis and an increased risk of subsequent cancer, even after adjusting for individual-level risk factors.

Cited by 103 publications

References 28 publications

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Guidelines of care for the management of basal cell carcinoma

Estimativa do custo do tratamento do câncer de pele tipo não-melanoma no Estado de São Paulo - Brasil

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