Nonmelanoma Cancers of the Skin

Preston, Diana S.; Stern, Robert S.

doi:10.1056/nejm199212033272307

Cited by 494 publications

(319 citation statements)

References 178 publications

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“…Squamous carcinoma is the most frequent skin cancer reported in transplant recipients. 11 However, in our series, we found a ratio of four basal cell carcinomas to every squamous carcinoma, the same distribution observed in the general population, 17 perhaps because our follow-up is short. This short follow-up and the limited number of patients are the main limitations of our study.…”

Section: Discussionsupporting

confidence: 80%

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Risk factors for development of de novo neoplasia after liver transplantation

Xiol

Guardiola²,

Menéndez

et al. 2001

Liver Transplantation

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Liver transplant recipients are at greater risk for de novo neoplasia, especially lymphoma and nonmelanoma skin cancer; however, risk factors for this complication have not been well studied. Clinical and pathological records of 137 consecutive liver transplant recipients who had survived for at least 1 year were reviewed to register de novo neoplasia. Ten variables were analyzed for their association with the development of de novo malignancies by means of a log-rank test and stepwise selection in a multivariate analysis using the Cox proportional hazard model. Thirty de novo neoplasias appeared in 22 of 137 transplant recipients between 12 and 104 months after orthotopic liver transplantation (OLT; median follow-up, 69 months): 14 patients had 21 skin cancers, 6 patients had solid-organ cancer, and 3 patients developed a lymphoproliferative disease. Probabilities of de novo neoplasia were 13% at 5 years post-OLT and 26% at 8 years post-OLT. The only associated risk factor for any neoplasia was age. Age and hepatocarcinoma were independent risk factors associated with skin cancer. That hepatocarcinoma in the explanted liver is an independent risk factor for skin cancer suggests there is individual susceptibility to both neoplasias. (Liver Transpl 2001;7:971-975.)

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Section: Discussionsupporting

confidence: 80%

“…This result was expected because the incidence of all neoplasias, including skin cancer, increases with age. 17 In the previously mentioned Dutch study, 8 greater age was the only risk factor associated with post-OLT cancer. In that study, most of the patients who developed a neoplasia were aged older than 40 years.…”

Section: Discussionmentioning

confidence: 88%

Risk factors for development of de novo neoplasia after liver transplantation

Xiol

Guardiola²,

Menéndez

et al. 2001

Liver Transplantation

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“…BCC is the commonest cancer overall in white people. [6][7][8] Although the prevalence of metastasis and mortality is very low 9,10 BCCs may grow aggressively causing extensive tissue destruction. 11 Over 30,000 new cases are reported each year in the UK.…”

mentioning

confidence: 99%

Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study

Bath‐Hextall

Leonardi‐Bee

Smith

et al. 2007

Intl Journal of Cancer

187

105

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We determined the trends in incidence of skin basal cell carcinoma (BCC) using a primary care population-based cohort study in the UK. 11,113 adults with a BCC diagnosis were identified from a total of 7.22 million person-years of data between 1996 and 2003 from the Health Improvement Network database. From a random subsample of BCC cases identified from the database, 93% were confirmed by hospital letter and/or pathology report. The incidence of BCC was 153.9 per 100,000 person-years (95% CI 151.1, 156.8) and was slightly higher in men as compared to women (Incidence Rate Ratio 1.10, 95% CI 1.06, 1.14). There was a 3% increase year on year across the study period (IRR 1.03, 95% CI 1.01, 1.04), with the largest increase in incidence seen in the 30-39 year age groups, although this did not reach statistical significance. Our study indicates 53,000 new cases of BCC are estimated every year in the UK and figures are continuing to rise on a yearly basis. Incidence rates are highest for men and in particular in the older age categories. These findings are consistent with those reported for various other populations. We have also found an increase in incidence in ages 30-39, which may suggest a cohort effect of increasing ultraviolet exposure in successive younger generations. This may have a huge public and service impact in future years in countries such as the UK, with predominantly fairskinned population, with high leisure exposure to ultraviolet light. Our findings underline the need for more elaborate preventive measures. ' 2007 Wiley-Liss, Inc.Key words: skin basal cell carcinoma; incidence; trend by age; UK The incidence of skin cancer is increasing worldwide 1-4 ; up to 10% annually. 5 Skin cancer is an increasing health problem placing a heavy burden on dermatologists and general practitioners (GP).Basal cell carcinoma (BCC) accounts for about 75% of all skin cancers, and along with squamous cell carcinoma and a few rarer types of skin cancer, is often referred to as non-melanoma skin cancer. BCC is the commonest cancer overall in white people. [6][7][8] Although the prevalence of metastasis and mortality is very low 9,10 BCCs may grow aggressively causing extensive tissue destruction. 11 Over 30,000 new cases are reported each year in the UK. This figure is likely to be a gross underestimate owing to Regional Cancer Registries 12 in the UK adopting different practices for registration of skin cancer, some registering only the first of each skin cancer type with others not registering BCCs at all. The situation is further complicated by the fact that some BCCs may be treated by destructive methods such as cryotherapy, with no resultant histology. Details of BCCs treated in this way may not reach the cancer registries, especially if they are treated in primary care.A sustained rise in the incidence of BCC has been documented using a validated register in South Wales. 13 In the US, the incidence of BCC has doubled approximately every 14 years 3 and similar changes have occurred in Australia. 14 Worryingly, th...

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“…Other works also recommend long follow-up although there is no consensus on this topic. 3,6,7 Besides that, subsequent annual follow-up favors the detection of new BCCs in less advanced stages.…”

Section: Comunicationmentioning

confidence: 99%

Recidivas e recorrências de carcinomas basocelulares da face

Ocanha

Dias

Miot

et al. 2011

An. Bras. Dermatol.

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Abstract:To evaluate factors related to oncological follow-up of basal cell face carcinomas it was carried out the analysis of a series of cases. Four hundred sixty-five patients with 834 basal cell face carcinomas were evaluated; 3,1% presented recurrences. There was 14.7% of recurrence in incompletely excised tumors against 2.3% of the tumors with clear margins. Recurrences were more prevalent on the nose. Relapse rates showed a cumulative risk. These findings reinforce the importance of oncological follow-up after surgery of basal cell carcinoma. Keywords: Carcinoma, basal cell; General surgery; Neoplasm recurrence, local; Pathology; skin neoplasms Resumo: Para avaliar fatores relacionados ao seguimento oncológico dos carcinomas basocelulares da face, foi realizada a análise de série de casos. Avaliaram-se 465 pacientes, com 834 carcinomas basocelulares de face; 3,1% apresentaram recidivas. Nos tumores incompletamente excisados, a recidiva foi 14,7% contra 2,3% dos tumores, com margens livres. Ocorreram mais na região nasal. As taxas de recorrência evidenciaram risco cumulativo. Estes achados reforçam a importância do seguimento oncológico após a cirurgia do carcinoma basocelular. Palavras-chave: Carcinoma basocelular; Cirurgia geral; Neoplasias cutâneas; Patologia; Recidiva local de neoplasia

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Nonmelanoma Cancers of the Skin

Cited by 494 publications

References 178 publications

Risk factors for development of de novo neoplasia after liver transplantation

Risk factors for development of de novo neoplasia after liver transplantation

Trends in incidence of skin basal cell carcinoma. Additional evidence from a UK primary care database study

Recidivas e recorrências de carcinomas basocelulares da face

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