Nonlinear Resistance Training Enhances the Lipid Profile and Reduces Inflammation Marker in People Living With HIV: A Randomized Clinical Trial

Zanetti, Hugo Ribeiro; Cruz, Lucas; Lourenço, Camilo Luís Monteiro; Ribeiro, Giovana Castilho; Leite, Marco Aurélio Ferreira de Jesus; Neves, Fernando Freitas; Silva‐Vergara, Mario León; Mendes, Edmar Lacerda

doi:10.1123/jpah.2015-0540

Cited by 26 publications

(35 citation statements)

References 13 publications

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“…Our results are consistent with four more recently published randomized controlled trials involving thrice weekly PRE with adults living with HIV. Authors reported similar improvements with PRE (or combined PRE and aerobic exercise) for outcomes of cardiorespiratory health, body composition, strength, quality of life, and CD4 count consistent with the results of this review [67–70]. …”

Section: Discussionsupporting

confidence: 85%

Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

O’Brien

Tynan²,

Nixon

et al. 2017

BMC Infect Dis

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BackgroundHIV is increasingly considered a chronic illness. More individuals are living longer and aging with the health-related consequences associated with HIV and multi-morbidity. Exercise is a self-management approach that can promote health for people aging with HIV. We examined the safety and effectiveness of progressive resistive exercise (PRE) interventions on immunological, virological, cardiorespiratory, strength, weight, body composition, and psychological outcomes in adults living with HIV.MethodsWe conducted a systematic review using the Cochrane Collaboration protocol. Searching databases up to April 2013, we included randomized controlled trials that compared PRE with no exercise or another intervention performed at least three times per week for at least four weeks with adults living with HIV. Two reviewers independently determined study eligibility. We extracted data from included studies and assessed risk of bias using the Cochrane Collaboration risk of bias tool. Meta-analyses were conducted using random effects models with Review Manager (RevMan) computer software.ResultsTwenty studies met inclusion criteria (n = 764 participants at study completion); the majority of participants were men (77%) taking antiretroviral therapy (14/20 included studies). Exercise interventions included PRE alone (8 studies) or a combination of resistive and aerobic exercise (12 studies) ranging from 6 to 52 weeks in duration. Thirty-four meta-analyses were performed. Results demonstrated statistically significant improvements in cardiorespiratory status (maximum oxygen consumption, exercise time), strength (chest press, knee flexion), weight, and body composition (arm and thigh girth, leg muscle area) among exercisers versus non-exercisers. We found no significant differences in change in CD4 count and viral load. We were unable to perform meta-analyses for psychological outcomes however results from individual studies demonstrated improvements in health-related quality of life with exercisers compared with non-exercisers.ConclusionsPerforming progressive resistive exercise (PRE) or a combination of resistive and aerobic exercise at least three times per week for at least six weeks is safe and can lead to improvements in cardiorespiratory fitness, strength, weight, and body composition for adults with HIV. Exercise may be considered a safe and beneficial for enhancing the health of medically stable adults aging with HIV.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2342-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 85%

Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

O’Brien

Tynan²,

Nixon

et al. 2017

BMC Infect Dis

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“…Zanetti et al (2016) reported the nonlinear resistance training group had reduced the levels of TC, LDL-c, and TG, and the HDL-c level increased (18); But their study period was 12 weeks in people living with HIV. Ribeiro et al (2016) after 8 weeks resistance training (traditional and pyramidal systems), a significant improvements were observed for TG, HDL-C, and LDL-C of older women in both systems (19) but the present research was conducted in 7 training sessions in young female student.…”

Section: Discussionmentioning

confidence: 98%

The Effect of a Short-Term Circuit Resistance Training on Blood Glucose, Plasma Lipoprotein and Lipid Profiles in Young Female Students

Tayebi

Mottaghi

Mahmoudi

et al. 2016

Jentashapir J Health Res

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Background: According to observations on the effect of exercise training on lipid profile, there is little evidence about the effect of short-term circuit resistance training in females because these researches often use aerobic methods in males. Objectives: The current study aimed to examine the effect of a short term course of circuit resistance training on blood glucose and serum lipids in female students. Methods: Twenty female students from the physical education in the luteal phase of their menstrual cycle were randomly selected and divided into two groups of 10 (resistance training and control groups). For seven consecutive days, the experimental group conducted a circuit resistance training including 10 exercises with the intensity of 60% of one maximum repetition and duration of 20 seconds for each exercise in four sets. Each session took 32 -40 minutes including warm-up and cool-down time. To measure fasting blood glucose, three glyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), very low density lipoprotein cholesterol (VLDL-c) and low density lipoprotein cholesterol (LDL-c), blood samples were taken 24 hours before the first session and after the seventh session in a 12-hour overnight fasting. Results: Analysis of variance for repeated measures revealed that although seven sessions of circuit resistance training with a moderate intensity had no significant effects on plasma HDL-c, VLDL-c, TC, and TG in the female students, a significant reduction was observed in the fasting blood glucose and plasma LDL-c. Conclusions: Resistance training exercises in the present method can be considered as a prophylaxis attempt against related diseases by improving cardiovascular and metabolic health.

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“…Furthermore, exercise intervention was applied to fifteen HIV-infected individuals between 35 and 51 years-of-age, and improvements in hand strength, scapular force, and several quality-of-life domains, including environment, perception of quality-of-life and global health [47,48]. Thirty HIV patients, undergoing highly active antiretroviral therapy, were either assigned to a nonlinear resistance exercise group or to a group with the exercise intervention interval covering 12 weeks [49]. After the 12-week intervention, the exercise group had augmented levels of lean body mass, with a reduction in body fat mass and body fat percentage whereas the levels of total cholesterol, low density lipoprotein cholesterol, triglyceride, and c-reactive protein were reduced, with the high density lipoprotein cholesterol level increased.…”

mentioning

confidence: 99%

Aspects of Cognition/Health Failure by HIV-infected Individuals: Amelioration through Exercise

Archer¹

2016

HIV Curr Res

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Nonlinear Resistance Training Enhances the Lipid Profile and Reduces Inflammation Marker in People Living With HIV: A Randomized Clinical Trial

Abstract: Twelve weeks of NLRT causes beneficial changes in the body composition, lipid profile, and inflammation markers in PLHIV, and it can be used in this patient population.

Cited by 26 publications

References 13 publications

Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol

The Effect of a Short-Term Circuit Resistance Training on Blood Glucose, Plasma Lipoprotein and Lipid Profiles in Young Female Students

Aspects of Cognition/Health Failure by HIV-infected Individuals: Amelioration through Exercise

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