Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort

Tovey, Euan R.; Almqvist, Catarina; Li, Qiang; Crisafulli, Daniel; Marks, Guy B.

doi:10.1016/j.jaci.2008.05.010

Cited by 94 publications

(75 citation statements)

References 43 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We will not detail these results in this section as several recent reviews have discussed this subject [40,41]. However, we would like to underline recent results, which suggest a nonlinear relationship between exposure to allergens and allergic diseases [42,43]: high exposure to HDM allergens might be protective against the risks of asthma and allergic sensitisation. This has been suggested by the ''high-dose tolerance'' hypothesis put forward for exposure to the cat allergen [44].…”

Section: Biological Pollutantsmentioning

confidence: 99%

Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

View full text Add to dashboard Cite

We reviewed the main epidemiological studies that evaluate the respiratory effects of indoor air pollutants quantitatively in industrialised countries. Consistent results support short-term (aggravation) and, although more rarely, long-term (prevalence augmentation) effects on asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD) in indoor settings with poor air quality. Environmental tobacco smoke is one of the most important risks for respiratory symptoms and diseases worldwide. The evidence is also reliable for indoor nitrogen dioxide and particulate matter, which have been associated with asthma, bronchitis and COPD. Whereas formaldehyde and volatile organic compounds seem to be the main pollutants in indoor settings, relevant papers on their respiratory effects are still scarce, and limited to asthma and bronchitis. Moulds have been associated with an increased risk of asthma and COPD. Contradictory results have been found between endotoxins and asthma. The role of phthalates, persistent organic pollutants and flame retardants in respiratory diseases remains to be established. Results from rural areas of industrialised countries indicate that exposure to some indoor bio-contaminants might be protective in early life, while it is associated with adverse respiratory adverse effects in adulthood. Studies focusing on indoor air pollutants should be developed to better understand their involvement in the inception and aggravation of respiratory diseases.

show abstract

Section: Biological Pollutantsmentioning

confidence: 99%

Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

View full text Add to dashboard Cite

show abstract

“…It was long believed that the load of mite allergens which a subject is exposed to could be an essential factor in determining simple sensitization or clinical allergy. However, recent data have indicated that this relationship is not linear, as the highest exposure to dust mites was not directly associated with the risk of allergic outcome [34]. Instead, the mite species seems to have an influence on the type of allergy which subjects develop: In a large group of around 1,700 children, respiratory allergy was associated with both D. pteronyssinus and D. farinae exposure, while only the latter one was associated with AD [19].…”

Section: Introductionmentioning

confidence: 99%

House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy

Fuiano

Fusilli

Incorvaia³

2009

Eur J Pediatr

View full text Add to dashboard Cite

The atopy patch test (APT) was recently defined as an important tool in diagnosis of atopic dermatitis (AD) and also of rhinitis and asthma caused by hypersensitivity to the house dust mites. We evaluated 465 children (279 males and 186 females) aged 0.4-17.6 years (mean 6.6 +/- 3.8 years), by dividing them into four groups: group A, current AD (40 patients); group B, current AD with respiratory symptoms (156 patients); group C, past AD with respiratory symptoms (203 patients); and the control group, respiratory symptoms with no history of AD (66 patients). The APT was significantly more frequently positive in groups with current AD (groups A and B) or past AD (group C) than in the control group, while skin prick test (SPT) and radioallergosorbent test (RAST) were significantly more frequently positive in the control group. With multivariate analysis, for APT, significant differences were found in the comparison between group A vs group B (odds ratio (OR) 1.55) and between group A vs group C (OR 1.81). The mean age was significantly lower in group A than in groups B, C, and the control group and with less significance in groups C vs D. Children sensitized to mites with current or past AD, with or without respiratory symptoms, have a different response to diagnostic tests, which is characterized by a highly significantly more frequent positive APT in comparison with subjects who have respiratory symptoms but a negative history for AD, who show the common response to SPT and RAST.

show abstract

“…All this suggests that infancy may be a critical time for exposure to common indoor allergens and later development of asthma. However, although the relationship between allergen exposure and asthma is widely accepted, several recent studies challenge this dose-response concept (67)(68)(69)(70) is associated with higher production of specifi c IgG4 antibody and decreased cat-specifi c IgE response, which could result in better protection against sensitisation (62,71,72). This induction of tolerance to Fel d 1 could actually reduce the risk of allergy development (11,18,71) In addition to mite, cockroach, and pet allergens, mould and pollen allergens, viral infections, and especially tobacco smoke may contribute to the development of sensitisation and respiratory diseases (2,10,73).…”

Section: Indoor Allergens and Asthmamentioning

confidence: 99%

Arthropod Allergens in Urban Homes

Prester¹

2012

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort

Cited by 94 publications

References 43 publications

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Respiratory health and indoor air pollutants based on quantitative exposure assessments

House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy

Arthropod Allergens in Urban Homes

Contact Info

Product

Resources

About