First a new autopilot design model is presented for the interceptor missile with the blended aerodynamic lift and reaction jet. The reaction jet can improve the response speed, but the structure of control system becomes more complex. Therefore how to design control strategy properly is an urgent problem. Second, considering the discrete property of the lateral pulse jet thrusters and the continuous property of the aerodynamic fins, a kind of ADRC (active disturbance rejection control) autopilot system was designed for the aerodynamic lift/reaction jet missile. Finally, through a testing in the simulation of MATLAB, it is shown that, due to the sufficient utilization of the reaction jet, there is a significant improvement in the fast response and robust performance of the proposed controller. It is applicable to design the autopilot of aerodynamic lift and reaction jet blended missile.