Nonionic Surfactants Enhancing Bactericidal Activity at Their Critical Micelle Concentrations

Tobe, Seiichi; Majima, Toshiaki; Tadenuma, Hirohiko; Suekuni, Tomonari; Sakai, Kenichi; Sakai, Hideki; Abe, Masahiko

doi:10.5650/jos.ess14159

Cited by 9 publications

(8 citation statements)

References 17 publications

(13 reference statements)

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“…Indeed, the high ζ -potential of co-micelles compared to pure C 12 E 8 micelles improves the probability of the attachment of [DiC 10 ] cations to the anionic regions ( i.e. phospholipids and proteins) prior to adsorption inside the envelope ( Tobe et al., 2015 ). It is believed that increasing the appearance of the cationic region of [DiC 10 ] cations in mixed micelles will increase the adsorption of [DiC 10 ] cations on the anionic region of the viruses.…”

Section: Resultsmentioning

confidence: 99%

How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?

Leclercq

Nardello‐Rataj

2020

European Journal of Pharmaceutical Sciences

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In response to the current pandemic situation, we present the development of an effective virucidal and biocidal solution to prevent from the spread of infectious diseases through contact with contaminated surfaces. The disinfectants, based on equimolar mixtures of didecyldimethylammonium chloride ([DiC 10 ][Cl]), dodecyloctaglycol (C 12 E 8 ), and cyclodextrin (CD), show synergistic effects against enveloped viruses (RSV, HSV-1, VACV) and fungi ( C. albicans ), and additive responses against bacteria ( P. aeruginosa ). These synergistic mixtures could then be highly helpful for prevention of respiratory illnesses, since a boosted activity allows: ( i ) a faster eradication of pathogens, ( ii ) a shorter contact time, and ( iii ) a complete and broad-spectrum eradication to avoid spread of resistant strains (including bacteria and fungi).

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Section: Resultsmentioning

confidence: 99%

How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?

Leclercq

Nardello‐Rataj

2020

European Journal of Pharmaceutical Sciences

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“…For example, the antimicrobial activity of the phenol type preservative is weakened in micellar solu-tion of nonionic surfactants, because the molecules are solubilized in the micelles or form a hydrophobic complex 43 45 . On the other hand, Tobe et al reported that bactericidal activities of benzalkonium chloride is stronger when the concentration of methyl ester ethoxylates type nonionic surfactant is greater than the CMC 46 .…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of the Mixed Systems Containing 1,2-Dodecanediol against <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>

et al. 2021

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S. epidermidis owing to its hydrophobic long alkyl chain.The antimicrobial behavior of 1,2-alkanediol in mixed systems with other components is unclear as only a single antimicrobial agent was added in these evaluation systems in previous study. However, various antimicrobial ingredients such as acids, salts, sebum and preservatives can coexist on the surface of the skin, if cosmetic and cleansing products containing 1,2-alkanediol are applied to keep the body clean and healthy 12 14 . These substances may affect the antimicrobial properties against skin bacteria. The antibacterial ability against S. aureus or E. coli was improved when 1,2-alkanediol was mixed with dipropylene glycol or phenoxyethanol 15,16 . Therefore, the antimicrobial behavior in mixed systems, including multiple antimicrobial agents, is important for the preparation of effective antimicrobial systems. The checkerboard method is useful for evaluating Abstract: 1,2-Alkanediols are characteristic cosmetic ingredients because these moisturizers exhibit the antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). However, the antimicrobial behavior in mixed systems containing several active ingredients is unclear because previous reports focus on an antibacterial system containing only 1,2-alkanediol. In this study, the minimal inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were evaluated for 1,2-dodecanediol/lactic acid, 1,2-dodecanediol/myristic acid, 1,2-dodecanediol/methylparaben, and 1,2-dodecanediol/isopropyl methylphenol mixed systems to show the effect of the addition of other antimicrobial components to 1,2-dodecanediol. The antibacterial property of 1,2-dodecanediol/lactic acid mixed system was almost similar compared to 1,2-dodecanediol monomeric system. On the other hand, the antimicrobial activity of 1,2-dodecanediol against S. epidermidis was inhibited in the 1,2-dodecanediol/ myristic acid mixed system. Because the selective antimicrobial activity of myristic acid against S. aureus was demonstrated in the mixed system. The present findings are useful for designing formulations of cosmetics and body cleansers containing 1,2-dodecanediol.

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“…Tobe et al . [65] observed that methyl ester ethoxylates increase the permeability of the Escherichia coli cell membrane. On the other hand, Fuchedzhieva et al .…”

Section: Resultsmentioning

confidence: 99%

“…The compounds with surface activity are considered as an important modifier of a cell membrane structure and its permeability [64]. Tobe et al [65] observed that methyl ester ethoxylates increase the permeability of the Escherichia coli cell membrane. On the other hand, Fuchedzhieva et al [66] noticed that benzene sulfonates (LAS) with linear alkyl chain did not affect the microbial cell permeability of Pseudomonas sp.…”

Section: Cell Surface Modificationsmentioning

confidence: 99%

Alkyl Xylosides: Physico‐Chemical Properties and Influence on Environmental Bacteria Cells

Smułek

Kaczorek

Hricovíniová

2017

J Surfact & Detergents

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A group of four selected non-ionic surfactants based on carbohydrates, namely octyl d-xyloside (C8X), nonyl d-xyloside (C9X), decyl d-xyloside (C10X) and dodecyl d-xyloside (C12X), have been investigated to accomplish a better understanding of their physico-chemical properties as well as biological activities. The surface-active properties, such as critical micelle concentration (CMC), emulsion and foam stability, the impact of the compounds on cell surface hydrophobicity and cell membrane permeability together with their toxicity on the selected bacterial strains have been determined as well. The studied group of surfactants showed high surface-active properties allowing a decrease in the surface tension to values below 25 mN m−1 for dodecyl d-xyloside at the CMC. The investigated compounds did not have any toxic influence on two Pseudomonas bacterial strains at concentrations below 25 mg L−1. The studied long-chain alkyl xylosides influenced both the cell inner membrane permeability and the cell surface hydrophobicity. Furthermore, the alkyl chain length, as well as the surfactant concentration, had a significant impact on the modifications of the cell surface properties. The tested non-ionic surfactants exhibited strong surface-active properties accompanied by the significant influence on growth and properties of Pseudomonas bacteria cells.

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Nonionic Surfactants Enhancing Bactericidal Activity at Their Critical Micelle Concentrations

Cited by 9 publications

References 17 publications

How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?

How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?

Antibacterial Activity of the Mixed Systems Containing 1,2-Dodecanediol against <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>

Alkyl Xylosides: Physico‐Chemical Properties and Influence on Environmental Bacteria Cells

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