Noninvasive quantitative assessment of oral tongue cancer by intraoral ultrasonography

Yamane, M.; Ishii, Junichi; Izumo, Toshiyuki; T, Nagasawa; Amagasa, Teruo

doi:10.1002/hed.20523

Cited by 41 publications

(43 citation statements)

References 20 publications

(34 reference statements)

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“…UTT was the most widely reported metric and was assessed in 10 of the 19 studies . The ability to accurately T stage tumors using dimensions obtained during sonographic examination was also investigated by two of the 19 studies Classification of deep margin shape was also used as a method to study different patterns of invasion by three studies . The categories used to describe different margin shapes, however, varied significantly across the three studies.…”

Section: Resultsmentioning

confidence: 99%

Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review

et al. 2018

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“…US can be used as a preoperative noninvasive tool with which to assess the histological structure of tongue cancer [2,[5][6][7][8][9][10][11][12][13][14]. Hayashi [15] reported that US should be routinely used as a standard technique to evaluate the depth of tumor invasion.…”

Section: Discussionmentioning

confidence: 98%

“…Preoperative ultrasonography (US) assessment is useful to noninvasively predict the prognosis of tongue cancer [2,3]. Some reports have demonstrated the usefulness of intraoral US for delineating the shape of the tumor margin, internal echo signal, tumor extent, and depth of invasion [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17]. US images reflect the histological structure of tongue cancers, even superficial carcinomas [2,[5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Peters and Withers [1] reported that a shorter total treatment duration is critical to improved patient outcomes. Preoperative ultrasonography (US) assessment is useful to noninvasively predict the prognosis of tongue cancer [2,3]. Some reports have demonstrated the usefulness of intraoral US for delineating the shape of the tumor margin, internal echo signal, tumor extent, and depth of invasion [2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography

et al. 2016

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Objectives To evaluate the feasibility of using ultrasoundobtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer. Methods Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as ''pressure,'' ''wedge-shaped,'' or ''permeated.'' Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived.Results The correlation between TD and MS was significant (Spearman rank correlation q = 0.552, p \ 0.01).Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: D ¼ À2:801 þ 0:093x þ 0:872y, where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was -0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p \ 0.05). The cut-off value for classifying cases was -0.00169. Using the formula above, 73.1 % of patients in the poor prognosis group were correctly classified.Conclusions MS and TD are useful predictors of tongue cancer prognosis.

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“…[1][2][3][4][5] Tumour thickness on intraoral ultrasonography images is reportedly an important predictor of cervical lymph node metastasis and patient outcome. [4][5][6][7][8] Invasion front ratio calculated from the length of the invasive front on intraoral ultrasonography images is related to the histopathological grade.…”

Section: Introductionmentioning

confidence: 99%

Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis

Yamamoto¹,

Yuasa²,

Okamura³

et al. 2016

Dentomaxillofacial Radiology

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Objectives: To quantitatively evaluate the relationship of vascularity of tongue cancer as demonstrated on intraoral ultrasonography images and tumour thickness with pathological grade of malignancy and the presence of cervical lymph node metastases. Methods: 18 patients with tongue cancer were enrolled in this retrospective study. Using Doppler ultrasonography images of the invasion front of the cancers along the length of their tumour boundaries, three vascular indexes were analysed quantitatively, namely ratio of blood flow signal area within the cancer to whole tumour area (BAR), blood flow signal number ratio (BNR) and blood flow signal width ratio (BWR). The associations between these three indexes and occurrence of cervical lymph node metastasis and pathological grade of malignancy [Yamamoto-Kohama (YK) classification] were assessed. Furthermore, the relationship between tumour thickness and occurrence of cervical lymph node metastasis was evaluated on B-mode intraoral ultrasonography images. Results: There was no significant association between BAR and tumour thickness or occurrence of cervical lymph node metastasis. The BNRs and BWRs of patients with cervical lymph node metastasis were significantly higher than those of patients without nodal involvement. The BWRs of patients with high-grade malignancy (YK-4C) were significantly higher than those of patients with low-grade malignancy (YK-2 or 3). Conclusions: BNR and BWR on the invasion front of the tongue cancer are predictors of pathological grade of malignancy and cervical lymph node metastasis. Dentomaxillofacial Radiology (2016Radiology ( ) 45, 20150372. doi: 10.1259 Cite this article as: Yamamoto C, Yuasa K, Okamura K, Shiraishi T, Miwa K. Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis. Dentomaxillofac Radiol 2016; 45: 20150372.

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Noninvasive quantitative assessment of oral tongue cancer by intraoral ultrasonography

Abstract: Intraoral ultrasonography in conjunction with the proposed CAD system allows tissue characterization and prediction of subclinical cervical lymph node metastasis.

Cited by 41 publications

References 20 publications

Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review

Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review

Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography

Vascularity as assessed by Doppler intraoral ultrasound around the invasion front of tongue cancer is a predictor of pathological grade of malignancy and cervical lymph node metastasis

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