Noninvasive, Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters

Jöbsis, Frans F.

doi:10.1126/science.929199

Cited by 3,496 publications

(1,806 citation statements)

References 18 publications

Supporting

Mentioning

1,711

Contrasting

Unclassified

Order By: Relevance

“…Temporally in tegrated measurements of CBF, however, have been made with iodoamphetamine or iodoantipy rine autoradiography (Ringel et aI.,199 1) or H2 15 0 positron emission tomography studies in humans (Phelps and Mazziotta, 1985). Vasodilatation has been determined videomicroscopicaJly (Ngai et a!., 1988) and increased CBV from hemoglobin spectro photometry (Jobsis, 1977;LaManna et aI., 1987), while recruitment has been demonstrated in hypox ia (Shockley and LaManna, 1988) and after stimu lation (Bereczki et aI., 1993). However, recruitment studies such as temporaJly integrative autoradio graphic experiments have been unable to confirm the delayed time scales of CBF and vasodilatation.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the absorption of excitation or emission wavelength light by moieties exhibiting activity-related (or un predictable) accumulation prevents quantitative flu orescence analyses. For example, hemoglobin ac cumulates locally post stimulation (Jobsis, 1977) and absorbs light at 578 nm, thus reducing the intensity of light available for dye excitation and thereby spu riously underestimating fluorescence. While trends remain intact, such effects prevent the numerical interpretation of fluorescence intensity as plasma (dye) volume when comparing pre-and poststimu Ius states.…”

Section: Vascular Fluorescence Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Functional Increases in Cerebral Blood Volume over Somatosensory Cortex

Narayan

Esfahani

Blood

et al. 1995

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary:We have examined the relationship between cerebral blood volume (CBV) and electrophysiology over primary somatosensory cortex (S-I) in the rat. We did this by comparing the spatial characteristics and time course of activity-related changes in plasma fluorescence, intrin sic optical reflectance signals, and single unit electro physiology in S-I to identical stimuli. S-Is of urethane anesthetized male Sprague-Dawley rats were exposed, and fluorescent Texas Red dextran dye (MW 70,000) was administered intravenously. Subsequently, foredigit elec troshock or vibrissal deflection was associated with fluo rescence increases over contralateral forelimb or postero medial barrel subfield cortex. Fluorescence was delayed and prolonged, indicating that CB V increases at 1-1.5 s and peaks 2-2.5 s after the onset of stimulation in both regions. When stimulus intensity was adjusted to produce barely detectable fluorescence foci (10% above back ground), significant electrophysiologic spiking was seen. At these parameters, fluorescence change overlay areas Cerebral metabolic activity and vascular perfu sion are functionally linked. Regional increases in perfusion have been used to map cerebral activation (Phelps and Mazziotta, 1985), and the characteriza tion of that functional perfusion has provided in sights into cerebral metabolism and neurovascular relationships. Positron emission tomography perfu sion studies have demonstrated the physiological uncoupling between oxygen supply and metabolic Received July 25, 1994; final revision received November 3, 1994; accepted November 5, 1994. Abbreviations used: CBV, cerebral blood volume; CCD, charge-coupled device; FL, forelimb cortex; PMBSF, postero medial barrel subfield; PSTH , peristimulus time histogram; S-I, primary somatosensory cortex; SNR, signal-to-noise ratio. 754of increased cortical layer III cell firing on single unit recordings. However, surface boundaries of the smallest observable fluorescence foci at their peak spatial extents consistently overspilled electrophysiologic center recep tive fields. Corresponding intrinsic optical reflectance de creases were seen at 610 and 850 nm, exhibiting similar timing and colocalizing closely with fluorescence increase at both wavelengths after identical stimuli. These signals similarly overspilled electrophysiologic activity. Thus, we observed delayed increases in vascular fluorescence (related to CBV) over activated cortex. The smallest de tectable fluorescence changes overspilled the center re ceptive field boundaries and were associated with appre ciable electrophysiologic firing. In addition, the striking spatial and temporal similarity between intrinsic optical reflectance and fluorescence activity suggests that changes in intrinsic cortical reflectance are strongly re lated to changes in CBV. Key Words: Cerebral blood vol ume-Electrophysiology-Somatosensory cortex.oxygen usage Fox et ai., 1986), as well as providing evidence for a human visual area V5 (Watson et ai., 1993). However, the spatial and temporal rel...

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Vascular Fluorescence Imagingmentioning

confidence: 99%

Functional Increases in Cerebral Blood Volume over Somatosensory Cortex

Narayan

Esfahani

Blood

et al. 1995

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…The underlying principles behind the use of NIRS to probe biologic media are relatively simple and have been described in detail elsewhere (Jobsis, 1977). As NIR light enters the tissue, it is multiply scattered and partially absorbed by four endogenous NIR light absorbers: HbO 2 , Hb, cytochrome oxidase, and water.…”

Section: Second Derivative Near-infrared Spectroscopymentioning

confidence: 99%

Measurement of Cerebral Oxidative Metabolism with Near-Infrared Spectroscopy: A Validation Study

Tichauer

Hadway

Lee

et al. 2005

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Predicting the onset of secondary energy failure after a hypoxic-ischemic insult in newborns is critical for providing effective treatment. Measuring reductions in the cerebral metabolic rate of oxygen (CMRO 2 ) may be one method for early detection, as hypoxia-ischemia is believed to impair oxidative metabolism. We have developed a near-infrared spectroscopy (NIRS) technique based on the Fick Principle for measuring CMRO 2 . This technique combines cerebral blood flow (CBF) measurements obtained using the tracer indocyanine green with measurements of the cerebral deoxy-hemoglobin (Hb) concentration. In this study, NIRS measurements of CMRO 2 were compared with CMRO 2 determined from the product of CBF and the cerebral arteriovenous difference in oxygen measured from blood samples. The blood samples were collected from a peripheral artery and the sagittal sinus. Eight piglets were subjected to five cerebral metabolic states created by varying the plane of anesthesia. No significant difference was found between CMRO 2 measurements obtained with the two techniques at any anesthetic level (P > 0.5). Furthermore, there was a strong correlation when concomitant CMRO 2 values from the two techniques were compared (R 2 = 0.88, P < 0.001). This work showed that CMRO 2 can be determined accurately by combining NIRS measurements of CBF and Hb. Since NIRS is safe and measurements can be obtained at the bedside, it is believed that this technique could assist in the early diagnosis of cerebral energy dysfunction after hypoxia-ischemia.

show abstract

“…10 It can also monitor intracellular oxygenation by measuring the reduction-oxidation changes of cytochrome oxidase (Cyt Ox), the terminal enzyme of the mitochondrial electron transport chain. 10,11 The use of NIRS for evaluating hepatic tissue oxygenation is limited to the authors 12 and one main group in Japan.…”

confidence: 99%

Changes in tissue oxygenation of the porcine liver measured by near-infrared spectroscopy

et al. 1999

View full text Add to dashboard Cite

Near-infrared spectroscopy (NIRS) is a novel method for the measurement of tissue oxygenation and may have a role in monitoring liver oxygenation and viability. The aim of this study is to validate the application of NIRS for monitoring hepatic tissue oxygenation. Large Landrace pigs (n ‫؍‬ 12) underwent laparotomy and liver exposure. Total hepatic blood flow (THBF) was measured by the Transonic Medical Flowmeter system. NIRS probes were placed on the liver surface to continuously record changes in hepatic tissue oxyhemoglobin (HbO 2 ), deoxyhemoglobin (Hb), and the reduction-oxidation state of cytochrome oxidase (Cyt Ox). Reduction of hepatic tissue oxygenation was achieved by hepatic vascular inflow occlusion (n ‫؍‬ 6) or reduction of inspired oxygen (FIO 2 ; n ‫؍‬ 6). The THBF changes correlated significantly with hepatic HbO 2 (r ‫؍‬ 0.84; P F .001) and Cyt Ox (r ‫؍‬ 0.88; P F .001). With reduction of FIO 2 , a significant correlation was found between arterial oxygen saturation and hepatic HbO 2 and Hb (r ‫؍‬ 0.99 and r ‫؍‬ ؊0.99, respectively; P F .0001). NIRS measurement of liver parenchymal oxygenation correlates well with changes in liver blood flow and arterial oxygenation.

show abstract

Noninvasive, Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters

Cited by 3,496 publications

References 18 publications

Functional Increases in Cerebral Blood Volume over Somatosensory Cortex

Functional Increases in Cerebral Blood Volume over Somatosensory Cortex

Measurement of Cerebral Oxidative Metabolism with Near-Infrared Spectroscopy: A Validation Study

Changes in tissue oxygenation of the porcine liver measured by near-infrared spectroscopy

Contact Info

Product

Resources

About