Changes in tissue oxygenation of the porcine liver measured by near-infrared spectroscopy

El-Desoky, A; Seifalian, Alexander M.; Cope, M; Delpy, David T.; Davidson, Brian R

doi:10.1002/lt.500050316

Cited by 33 publications

(43 citation statements)

References 26 publications

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“…11,38,39 Several case reports have shown significant mesenteric desaturation in infants with necrotizing enterocolitis that normalized after treatment. 40,41 Early recognition of mesenteric ischemia before the occurrence of intestinal infarction would be clinically important.…”

Section: Discussionmentioning

confidence: 99%

Regional tissue oxygenation in preterm born infants in association with echocardiographically significant patent ductus arteriosus

2011

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Objective: To analyze the levels of regional tissue oxygenation in preterm infants in association with echocardiographically significant patent ductus arteriosis (PDA).Study Design: Preterm infants with gestational age less than 32 week were enrolled before the first dose of the pharmacological treatment for the PDA. Non-invasive near-infrared spectroscopy (NIRS) technology was utilized to measure cerebral (rSO 2 -C), renal (rSO 2 -R) and mesenteric (rSO 2-M ) tissue oxygenation for approximately 60 min. Regional fractional oxygen extraction (FOE) was calculated using simultaneously measured arterial saturation (SaO 2 ). We analyzed regional tissue oxygenation and oxygen extraction, hemodynamic parameters, and demographic and clinical information in association with the size of the PDA (moderate vs large).Result: Among the 38 enrolled infants, the majority were diagnosed with a large (63.2%, n ¼ 24) and the rest with a moderate-sized PDA. Infants with large and moderate PDA were comparable in terms of gestational age, study age and weight, mode of delivery and hemodynamic parameters. A significantly higher proportion of infants with a moderate PDA were mechanically ventilated as compared with those with a large PDA. We found no significant differences in the rSO 2 -C and rSO 2 -R, irrespective of the type of respiratory support. However, in infants with a large PDA on continuous nasal positive airway pressure (NCPAP), the rSO 2 -M was lower and mesenteric FOE was higher than that in mechanically ventilated neonates with a large PDA, and in those with moderate PDA irrespective of the type of respiratory support. Conclusion:The PDA size did not affect cerebral and renal tissue oxygenation, but the mesenteric tissue oxygenation was decreased in infants with a large PDA on NCPAP.

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Section: Discussionmentioning

confidence: 99%

Regional tissue oxygenation in preterm born infants in association with echocardiographically significant patent ductus arteriosus

2011

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“…The fraction of inspired oxygen (FiO 2 ) was reduced in stepwise function from FiO 2 of 30% (baseline) to 20,15,10,8,6, and 4%. Five minutes were allowed at each hypoxaemia level before blood samples were taken.…”

Section: Experimental Protocolmentioning

confidence: 99%

“…The difference between transmitted and received light intensity at each wavelength was used to determine the optical density changes at each wavelength. A computer program, developed for hepatic tissue [8], was used to compute continuously hepatic HbO 2 , Hb and Cyt Ox concentration changes in micromole per litre of tissue. In addition, the sum of HbO 2 + Hb (HbT) was computed continuously and reflects the liver blood volume [8].…”

Section: Near Infrared Spectroscopymentioning

confidence: 99%

“…A computer program, developed for hepatic tissue [8], was used to compute continuously hepatic HbO 2 , Hb and Cyt Ox concentration changes in micromole per litre of tissue. In addition, the sum of HbO 2 + Hb (HbT) was computed continuously and reflects the liver blood volume [8]. The differential pathlength factor of the pig's liver is 2.7, which was measured by direct time of flight measurement and used in this study [17].…”

Section: Near Infrared Spectroscopymentioning

confidence: 99%

“…A new algorithm for measurement of hepatic tissue oxygenation using NIRS has been developed and validated for measuring tissue oxygenation changes with alterations to hepatic blood flow [8]. Graded hypoxia and its effect on liver tissue oxygenation have also been investigated [9].…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Hepatic Tissue Hypoxia Using Near Infrared Spectroscopy: Comparison with Hepatic Vein Oxygen Partial Pressure

et al. 2000

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Hepatic hypoxia occurs during liver surgery and transplantation. The critical level associated with irreversible hepatocellular damage is unknown. Measurement of hepatic tissue oxygenation and hepatic vein oxygen partial pressure (HVPO₂) reflects oxygen supply and consumption. Near infrared spectroscopy (NIRS) can be used to monitor hepatic oxyhaemoglobin (HbO₂), deoxyhaemoglobin (Hb) and cytochrome oxidase (Cyt Ox) oxidation. This study compared regional hepatic tissue oxygenation (HbO₂, Hb and Cyt Ox) using NIRS with HVPO₂. The use of tissue oxygenation measured by NIRS and HVPO₂ as indicators of hepatic tissue hypoxia was also investigated. Large Landrace pigs (n = 5) underwent laparotomy and liver exposure. Systemic and hepatic haemodynamics were monitored continuously. NIRS probes were placed on the liver to record continuously HbO₂, Hb and Cyt Ox. Graded hypoxaemia was achieved by stepwise reduction of the fraction of inspired oxygen (FiO₂) from 30% (baseline) to 4%. A significant decrease in hepatic arterial blood flow and total hepatic blood flow was seen with severe hypoxaemia while there was no significant change to portal vein blood flow. Oxygen partial pressures in the hepatic artery, portal vein and hepatic vein decreased progressively with all grades of hypoxaemia. There was an immediate reduction of hepatic HbO₂ and simultaneous increase in hepatic Hb with all grades of hypoxaemia. Hepatic Cyt Ox was reduced significantly only with FiO₂ ≤10%. A significant correlation (p < 0.001) was found between the changes in hepatic oxygenation parameters measured by NIRS and HVPO₂. HVPO₂ measurement did not predict the reduction in intracellular tissue oxygenation demonstrated by NIRS with a decrease of Cyt Ox oxidation. In conclusion there was a good correlation between the tissue oxygenation parameters measured by NIRS and HVPO₂. However, the reduction of intracellular oxygenation found with severe hypoxaemia was demonstrated only by NIRS.

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Noninvasive Diagnoses by Near‐Infrared Spectroscopy

Alam

2001

Handbook of Vibrational Spectroscopy

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The sections in this article are Introduction The Study of Human Peripheral Muscle Organ Perfusion and Metabolism Skin Monitoring Tumor Detection Detection of p H in Blood and Tissue Lipids and Proteins Body Composition Conclusion

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Changes in tissue oxygenation of the porcine liver measured by near-infrared spectroscopy

Cited by 33 publications

References 26 publications

Regional tissue oxygenation in preterm born infants in association with echocardiographically significant patent ductus arteriosus

Regional tissue oxygenation in preterm born infants in association with echocardiographically significant patent ductus arteriosus

Measurement of Hepatic Tissue Hypoxia Using Near Infrared Spectroscopy: Comparison with Hepatic Vein Oxygen Partial Pressure

Noninvasive Diagnoses by Near‐Infrared Spectroscopy

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