Noninvasive evaluation of airway inflammation in asthmatic patients who smoke: implications for application in clinical practice

Bessa, Vasiliki; Tseliou, Eleni; Bakakos, Petros; Loukides, Stelios

doi:10.1016/s1081-1206(10)60485-1

Cited by 15 publications

(9 citation statements)

References 47 publications

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“…According to previous studies on smokers the reduction of nasal NO [26] and exhaled NO [27] has been significant. The different out-come in our study might be due to the low cigarette consumption.…”

Section: Discussionmentioning

confidence: 99%

Acoustic rhinometry, spirometry and nitric oxide in relation to airway allergy and smoking habits in an adolescent cohort

Irander¹,

Borres

Palm

2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Acoustic rhinometry, spirometry and nitric oxide in relation to airway allergy and smoking habits in an adolescent cohort

Irander¹,

Borres

Palm

2011

International Journal of Pediatric Otorhinolaryngology

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“…FENO levels positively correlate with male gender,11 older age, lower body mass index, allergic sensitization,12 pollen13 or air pollution exposure,14 sputum eosinophils,15,16 persistent airway inflammation responsive to inhaled corticosteroids,17,18 Asian ethnicity,19 morning time of day,20 gene polymorphisms in the nitric oxide pathway21 and acute stress. Smoking or exposure to secondhand smoke also modestly reduces FENO 22–24. Importantly, FENO does not consistently correlate with lung function25,26 or bronchial hyperreactivity 27.…”

Section: Fractional Expired Nitric Oxidementioning

confidence: 95%

Role of biomarkers in understanding and treating children with asthma: towards personalized care

Lang¹,

Blake²

2013

PGPM

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Asthma is one of the most common chronic diseases affecting children. Despite publicized expert panels on asthma management and the availability of high-potency inhaled corticosteroids, asthma continues to pose an enormous burden on quality of life for children. Research into the genetic and molecular origins of asthma are starting to show how distinct disease entities exist within the syndrome of “asthma”. Biomarkers can be used to diagnose underlying molecular mechanisms that can predict the natural course of disease or likely response to drug treatment. The progress of personalized medicine in the care of children with asthma is still in its infancy. We are not yet able to apply stratified asthma treatments based on molecular phenotypes, although that time may be fast approaching. This review discusses some of the recent advances in asthma genetics and the use of current biomarkers that can help guide improved treatment. For example, the fraction of expired nitric oxide and serum Immunoglobulin E (IgE) (including allergen-specific IgE), when evaluated in the context of recurrent asthma symptoms, are general predictors of allergic airway inflammation. Biomarker assays for secondhand tobacco smoke exposure and cysteinyl leukotrienes are both promising areas of study that can help personalize management, not just for pharmacologic management, but also education and prevention efforts.

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“…Mast cells play a crucial role in allergic reactions [18]. Interestingly, emerging evidence also suggests a role of mast cells in the pathogenesis of emphysema [19, 20]. Kalenderian et al [19, 20] found that the levels of mast cell mediators, such as histamine and tryptase, are considerably elevated in BALF from smokers.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, emerging evidence also suggests a role of mast cells in the pathogenesis of emphysema [19, 20]. Kalenderian et al [19, 20] found that the levels of mast cell mediators, such as histamine and tryptase, are considerably elevated in BALF from smokers. The importance of mast cells is further supported by the fact that mast cell tryptase activity is correlated with the severity of COPD [21], and in COPD patients an accumulation of mast cells in the airways has been observed [22].…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoke Suppresses the Surface Expression ofc-kitand FcεRI on Mast Cells

Givi

Blokhuis

Silva

et al. 2013

Mediators of Inflammation

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Chronic obstructive pulmonary disease (COPD) is a multicomponent disease characterized by emphysema and/or chronic bronchitis. COPD is mostly associated with cigarette smoking. Cigarette smoke contains over 4,700 chemical compounds, including free radicals and LPS (a Toll-Like Receptor 4 agonist) at concentrations which may contribute to the pathogenesis of diseases like COPD. We have previously shown that short-term exposure to cigarette smoke medium (CSM) can stimulate several inflammatory cells via TLR4 and that CSM reduces the degranulation of bone-marrow-derived mast cells (BMMCs). In the current study, the effect of CSM on mast cells maturation and function was investigated. Coculturing of BMMC with CSM during the development of bone marrow progenitor cells suppressed the granularity and the surface expression of c-kit and FcεRI receptors. Stimulation with IgE/antigen resulted in decreased degranulation and release of Th1 and Th2 cytokines. The effects of CSM exposure could not be mimicked by the addition of LPS to the culture medium. In conclusion, this study shows that CSM may affect mast cell development and subsequent response to allergic activation in a TLR4-independent manner.

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Noninvasive evaluation of airway inflammation in asthmatic patients who smoke: implications for application in clinical practice

Cited by 15 publications

References 47 publications

Acoustic rhinometry, spirometry and nitric oxide in relation to airway allergy and smoking habits in an adolescent cohort

Acoustic rhinometry, spirometry and nitric oxide in relation to airway allergy and smoking habits in an adolescent cohort

Role of biomarkers in understanding and treating children with asthma: towards personalized care

Cigarette Smoke Suppresses the Surface Expression ofc-kitand FcεRI on Mast Cells

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