Acoustic rhinometry, spirometry and nitric oxide in relation to airway allergy and smoking habits in an adolescent cohort

Irander, Kristina; Borres, Magnus P.; Palm, Jörgen

doi:10.1016/j.ijporl.2010.10.029

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…On the other hand, a recent study of a cohort of adolescents demonstrated lower, albeit not significantly, nNO values in active smokers compared to non-smokers. 68 Table 2 summarizes individual and environmental factors that may affect nNO values. 12,37,38,[69][70][71][72][73][74][75] Compared to velum closure techniques, tidal breathing results in significantly reduced nNO levels.…”

Section: Yes/no 1mentioning

confidence: 99%

“…These authors also demonstrated that nNO concentration depends on the environmental NO and, in children younger than 12 years, on patient's age, while sex, passive smoking, body mass index, weight, and height do not seem to influence it. On the other hand, a recent study of a cohort of adolescents demonstrated lower, albeit not significantly, nNO values in active smokers compared to non‐smokers . Table summarizes individual and environmental factors that may affect nNO values .…”

Section: Introductionmentioning

confidence: 99%

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Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Manna

Montella

Maniscalco³

et al. 2014

Pediatric Pulmonology

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Nitric oxide plays an important role in several physiological and pathophysiological processes in the respiratory tract. Different ways to measure nasal nitric oxide levels in children are currently available. The possibility of obtaining nasal nitric oxide measurement from relatively young children, combined with the availability of portable devices that can be used even in the office setting, opens new perspectives for nasal nitric oxide analysis in the pediatric daily practice. This review presents a synopsis about the current clinical applications of nasal nitric oxide measurement in the pediatric clinical practice. A total of 3,775 articles on the topic were identified, of which 883 duplicates were removed, and 2,803 were excluded based on review of titles and abstracts. Eighty-nine full text articles were assessed for eligibility and 32 additional articles were obtained from the reference lists of the retrieved studies. Since very low nasal nitric oxide levels are found in the majority of patients with primary ciliary dyskinesia, most publications support a central role for nasal nitric oxide to screen the disease, and indicate that it is a very helpful first-line tool in the real-life work-up in all age groups. Decreased nasal nitric oxide concentration is also typical of cystic fibrosis, even though nasal nitric oxide is not as low as in primary ciliary dyskinesia. In other upper airway disorders such as allergic rhinitis, rhinosinusitis, nasal polyposis, and adenoidal hypertrophy, clinical utility of nasal nitric oxide is still critically questioned and remains to be established. Since nNO determination is flow dependent, a general consensus from the major investigators in this area is highly desirable so that future studies will be performed with the same flow rate. A shared nNO methodology will enable to overcome the challenges that lie ahead in incorporating nNO measurement into the mainstream clinical setting of pediatric airway diseases.

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Section: Yes/no 1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Manna

Montella

Maniscalco³

et al. 2014

Pediatric Pulmonology

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“…Previous studies have shown that smoking decreased nasal NO levels. [14,15] Low levels of NO were also detected in patients with severe nasal obstruction and inflammation. [16][17][18] The association of asthma with AR is well known, and it is also well known that AR is a risk factor for asthma.…”

Section: Discussionmentioning

confidence: 99%

Nasal nitric oxide and its metabolites as potential biomarkers for the diagnosis and follow-up of allergic rhinitis

Çoşkun¹,

Arslan²,

İmamoğlu³

2017

ENT Updates

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The effects of physical exercise and smoking habits on the expression of SPLUNC1 in nasal lavage fluids from allergic rhinitis subjects

Irander

Borres

Ghafouri

2014

International Journal of Pediatric Otorhinolaryngology

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Current allergen exposure has an impact on SPLUNC1 expression in nasal lavage fluid, why allergy ought to be considered in study populations where analyses of SPLUNC1 levels are included in the reports. The normal nasal decongestion after exercise was not affected by allergy in contrast to smoking habits. The correlation between SPLUNC1 levels and Vol2(increase) in non-smokers may indicate involvement of SPLUNC1in the regulation of the normal function of the nasal mucosa. Complementary studies are needed to confirm the smoke-related reduction of SPLUNC1 expression and to analyze the possible participation of SPLUNC1 in the nasal mucosa regulation.

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Acoustic rhinometry, spirometry and nitric oxide in relation to airway allergy and smoking habits in an adolescent cohort

Cited by 4 publications

References 29 publications

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Clinical application of nasal nitric oxide measurement in pediatric airway diseases

Nasal nitric oxide and its metabolites as potential biomarkers for the diagnosis and follow-up of allergic rhinitis

The effects of physical exercise and smoking habits on the expression of SPLUNC1 in nasal lavage fluids from allergic rhinitis subjects

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