Noninvasive estimation of impaired hemodynamics for patients with acute myocardial infarction by Tei index

Takasaki, Kunitsugu; Shiro, Yoshitsugu; Kuwahara, Eiji; Yuasa, Toshinori; Rahim, Alaa Eldin Rabea Abd El; Matsukida, Keiko; Kumanohoso, Toshiro; Toyonaga, Kouichi; Kisanuki, Akira; Minagoe, Shinichi

doi:10.1016/j.echo.2004.02.020

Cited by 10 publications

(3 citation statements)

References 31 publications

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“…2,5 A significant relationship between reduced %FS and the survival in the current study confirmed these reports. In addition, the Tei index closely correlates with patient prognosis, 2-5,13 hemodynamics, [14][15][16] and others. [17][18][19][20][21][22] The present study confirmed these previous findings and further demonstrated the usefulness of the Tei index in the UM-X7.1 hamster model of CHF.…”

Section: Discussionmentioning

confidence: 89%

Prediction of Prognosis in the UM-X7.1 Hamster Model of Congestive Heart Failure Using the Tei Index

Shiro

Ikeda

et al. 2005

Circ J

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ardiac function is difficult to evaluate in small animal models of congestive heart failure (CHF). The Tei index, defined as the sum of isovolume contraction time (ICT) and isovolume relaxation time (IRT) divided by ejection time (ET), can express both systolic and diastolic function. Therefore, global left ventricular (LV) function can be determined and the prognosis of patients with cardiac dysfunction or CHF can be predicted. [1][2][3][4][5] Because of its simplicity, the Tei index can be applicable to even small animal models of CHF. 6 However, the ability of the Tei index to predict the outcome in a small animal model of CHF has not been fully investigated. Therefore, we postulated that the Tei index could also predict the prognosis of animal models of CHF. The present study investigates the relationship between the Tei index and survival in an animal model of CHF. Methods Animal ModelThe study included 48 male UM-X7.1 hamsters at an average age of 19.7±0.4 weeks. Heart function is normal in this model at 15 weeks of age, but cardiac dysfunction be- Circulation Journal Vol.69, August 2005comes significant without overt CHF at 20 weeks. CHF becomes overt at 27 weeks, and cardiac death occurs between 27 and 44 weeks. 7-9 Therefore, these animals have significant cardiac dysfunction but without obvious CHF at 20 weeks of age. The institutional committee of Kagoshima University approved the study protocol. Doppler EchocardiographyStandard 2-dimensional and Doppler echocardiography Background Cardiac function is difficult to evaluate in small animal models of heart disease. The Doppler Tei index is a simple and non-invasive measure that can express global cardiac function even in small animal models of congestive heart failure. However, its ability to predict prognosis has not been evaluated. Methods and ResultsWe tested the hypothesis that cardiac functional indices, such as the Tei index, can predict the prognosis of hamsters with cardiac dysfunction. The Tei index, defined as the sum of the isovolume contraction and relaxation time divided by ejection time, and the percent fractional shortening of the left ventricle was measured in 48 anesthetized male hamsters (19.7±0.4 weeks old) with cardiac dysfunction (UM-X7.1), using Doppler and 2-dimensional echocardiography. The hamsters were separated into 2 groups based on the median Tei index (0.50) and % fractional shortening (FS) (21%). Kaplan-Meier analysis determined the survival rates of the groups. Both the Tei index and %FS enabled significant distinction of better and poorer survival (p<0.01), and the survival curves were less overlapped when the animals were separated according to the Tei index. Conclusion The Tei index can predict prognosis in a small animal model of heart failure. (Circ J 2005; 69: 991 -993)

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Section: Discussionmentioning

confidence: 89%

Prediction of Prognosis in the UM-X7.1 Hamster Model of Congestive Heart Failure Using the Tei Index

Shiro

Ikeda

et al. 2005

Circ J

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“…Accordingly, the feasibility of using E/e’ and TE–e’, as obtained with use of a dual Doppler system, was possible for use in the evaluation of LV filling pressure in patients with AF and a wide range of LVEFs. The results of Takasaki et al suggest that the Tei index, combining systolic and diastolic function, and showing significant correlations both with pulmonary capillary wedge pressure and cardiac index, enabled a better evaluation of cardiac function [20]. Our current results demonstrating increased levels of E/e’(S), E/e’(L),the Tei index and TE-e’ within the AF group are in good agreement with these previous studies [10, 18–20].…”

Section: Discussionmentioning

confidence: 99%

Value of dual Doppler echocardiography for prediction of atrial fibrillation recurrence after radiofrequency catheter ablation

Chen

Sun

et al. 2019

BMC Cardiovasc Disord

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BackgroundIncreasing evidence has been presented which suggests that left ventricular (LV) diastolic dysfunction may play an important role in the development of atrial fibrillation (AF). However, the potential for LV diastolic dysfunction to serve as a predictor of AF recurrence after radiofrequency catheter ablation remains unresolved.MethodsDual Doppler and M-PW mode echocardiography were performed in 67 patients with AF before ablation and 47 patients with sinus rhythm. The parameters measured within identical cardiac cycles included, the time interval between the onset of early transmitral flow peak velocity (E) and that of early diastolic mitral annular velocity (e’) (TE-e’), the ratio of E to color M-mode Doppler flow propagation velocity (Vp)(E/Vp), the Tei index, the ratio of E and mitral annular septal (S) peak velocity in early diastolic E/e’(S) and the ratio of E and mitral annular lateral (L) peak velocity E/e’(L). A follow-up examination was performed 1 year after ablation and patients were divided into two groups based on the presence or absence of AF recurrence. Risk estimations for AF recurrence were performed using univariate and multivariate logistic regression.ResultsTE-e’, E/Vp, the Tei index, E/e’(S) and E/e’(L) were all increased in AF patients as compared with the control group (p < 0.05). At the one-year follow-up examination, a recurrence of AF was observed in 21/67 (31.34%) patients. TE-e’ and the Tei index within the recurrence group were significantly increased as compared to the group without recurrence (p < 0.001). Results from multivariate analysis revealed that TE-e’ can provide an independent predictor for AF recurrence (p = 0.001).ConclusionsDual Doppler echocardiography can provide an effective and accurate technique for evaluating LV diastolic function within AF patients. The TE-e’ obtained within identical cardiac cycles can serve as an independent predictor for the recurrence of AF as determined at 1 year after ablation.

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“…Since the Tei index reflects global cardiac function, it is related to multiple pathophysiology, which is related to cardiac function. 17 Such applications include the prediction of patient survival, 19,20,31 prediction of congestive heart failure or complications after AMI, [32][33][34] screening to identify patients with elevated LV filling pressure, 35,36 differentiation of pseudonormal from normal mitral flow, 37 early detection of cardiac toxicity from anthracycline, 38 evaluation of right ventricular function 39 and serial evaluation of the natural course or therapeutic procedures. 40,41 The present study showed a novel clinical application of the Tei index for evaluating important pathophysiology or coronary reperfusion in patients with first anteroseptal AMI without other coronary lesions or LV hypertrophy.…”

Section: Relationship To Previous Studiesmentioning

confidence: 99%

Increased Tei Index Suggests Absence of Adequate Coronary Reperfusion in Patients With First Anteroseptal Acute Myocardial Infarction

Kuwahara

Takasaki

Yuasa

et al. 2006

Circ J

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Noninvasive estimation of impaired hemodynamics for patients with acute myocardial infarction by Tei index

Cited by 10 publications

References 31 publications

Prediction of Prognosis in the UM-X7.1 Hamster Model of Congestive Heart Failure Using the Tei Index

Prediction of Prognosis in the UM-X7.1 Hamster Model of Congestive Heart Failure Using the Tei Index

Value of dual Doppler echocardiography for prediction of atrial fibrillation recurrence after radiofrequency catheter ablation

Increased Tei Index Suggests Absence of Adequate Coronary Reperfusion in Patients With First Anteroseptal Acute Myocardial Infarction

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