Noninvasive Determination of Melanoma Depth using a Handheld Photoacoustic Probe

Zhou, Yong; Tripathi, Shivani; Rosman, Ilana S.; Ma, Jun; Hai, Pengfei; Linette, Gerald P.; Fields, Ryan C.; Wang, Lihong V.; Cornelius, Lynn A.

doi:10.1016/j.jid.2017.01.016

Cited by 63 publications

(59 citation statements)

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“…sO 2 can then be measured, which is an important indicator of tumor metabolism and therapeutic response. Oncologic applications of PAT to date include breast cancer (9)(10)(11)(12)(13), prostate cancer (14,15), skin cancer (16,17), thyroid cancer (18), and ovarian cancer (19)(20)(21)(22).…”

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confidence: 99%

Evaluation of Ovarian Cancer: Initial Application of Coregistered Photoacoustic Tomography and US

et al. 2018

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Purpose To assess transvaginal coregistered photoacoustic tomography (PAT) and pulse-echo US for diagnosis of ovarian cancer based on functional parameters provided by PAT. Materials and Methods Between February 2017 and December 2017, 26 ovarian masses from 16 participants were successfully imaged in vivo by multispectral photoacoustic imaging, including nine invasive epithelial ovarian cancers (six serous carcinomas and three endometroid adenocarcinomas), three other tumors (two borderline serous tumors and one sex cord-stromal tumor), and 14 benign and normal (hereafter referred to as benign/normal) ovaries. The relative total hemoglobin concentration (rHbT) and mean oxygen saturation (sO) shown at PAT were used to characterize the ovaries identified at US. Results The average rHbT was 1.9 times higher for invasive epithelial cancers than for the benign/normal ovaries (P = .01). Additionally, the rHbT distribution was extensive in invasive epithelial cancers, but was scattered in benign/normal ovaries. However, the rHbT of two borderline serous tumors and one stromal tumor was in the same range as that of benign/normal ovaries. The mean sO of invasive epithelial cancers, and of the borderline and stromal tumors, was 8.2% lower than that of benign/normal ovaries (P = .003). Discussion Invasive epithelial ovarian cancers showed higher and extensive tumor vascularity and lower oxygen saturation than benign and normal ovaries. Two borderline noninvasive serous and one stromal tumor showed low oxygen saturation compared with benign and normal ovaries. ©RSNA, 2018 Online supplemental material is available for this article.

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confidence: 99%

Evaluation of Ovarian Cancer: Initial Application of Coregistered Photoacoustic Tomography and US

et al. 2018

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“…5 In recent years, PA imaging systems have been investigated worldwide for clinical applications. 6,7 However, the previous clinical PA systems are limited because of their single anatomical availability (e.g. breast only), clinically irrelevant US transducer (e.g.…”

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confidence: 99%

Multispectral ex vivo photoacoustic imaging of cutaneous melanoma for better selection of the excision margin

Kim

Park

et al. 2018

Br J Dermatol

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“…LA-PAT has been demonstrated to detect and quantify CTC clusters. In addition, photoacoustic imaging can measure other important biological parameters, including tumor depth, the oxygen saturation of hemoglobin, metabolic rate, and tumor stiffness [26][27][28][29] , all of which are closely related to metastasis [30][31][32] . With the capability to detect and quantify CTC clusters and the potential to provide multidimensional information on tumor metastasis, LA-PAT is a promising tool for both preclinical cancer metastasis study and clinical tumor therapy.…”

Section: Resultsmentioning

confidence: 99%

Linear-array-based photoacoustic tomography for label-free high-throughput detection and quantification of circulating melanoma tumor cell clusters

Hai

Zhou

Zhang

et al. 2017

Photons Plus Ultrasound: Imaging and Sensing 2017

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Circulating tumor cell (CTC) clusters arise from multicellular grouping in the primary tumor and elevate the metastatic potential by 23 to 50 fold compared to single CTCs. High throughout detection and quantification of CTC clusters is critical for understanding the tumor metastasis process and improving cancer therapy. In this work, we report a lineararray-based photoacoustic tomography (LA-PAT) system capable of label-free high-throughput CTC cluster detection and quantification in vivo. LA-PAT detects CTC clusters and quantifies the number of cells in them based on the contrast-to-noise ratios (CNRs) of photoacoustic signals. The feasibility of LA-PAT was first demonstrated by imaging CTC clusters ex vivo. LA-PAT detected CTC clusters in the blood-filled microtubes and computed the number of cells in the clusters. The size distribution of the CTC clusters measured by LA-PAT agreed well with that obtained by optical microscopy. We demonstrated the ability of LA-PAT to detect and quantify CTC clusters in vivo by imaging injected CTC clusters in rat tail veins. LA-PAT detected CTC clusters immediately after injection as well as when they were circulating in the rat bloodstreams. Similarly, the numbers of cells in the clusters were computed based on the CNRs of the photoacoustic signals. The data showed that larger CTC clusters disappear faster than the smaller ones. The results prove the potential of LA-PAT as a promising tool for both preclinical tumor metastasis studies and clinical cancer therapy evaluation.

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Noninvasive Determination of Melanoma Depth using a Handheld Photoacoustic Probe

Cited by 63 publications

References 10 publications

Evaluation of Ovarian Cancer: Initial Application of Coregistered Photoacoustic Tomography and US

Evaluation of Ovarian Cancer: Initial Application of Coregistered Photoacoustic Tomography and US

Multispectral ex vivo photoacoustic imaging of cutaneous melanoma for better selection of the excision margin

Linear-array-based photoacoustic tomography for label-free high-throughput detection and quantification of circulating melanoma tumor cell clusters

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