Multispectral <i>ex vivo</i>
 photoacoustic imaging of cutaneous melanoma for better selection of the excision margin

Kim, J.; Kim, Yeo Hyung; Park, B.; Seo, Hyun-Min; Bang, Chul Hwan; Park, G.S.; Park, Y.M.; Rhie, Jong Won; Lee, J.H.; Kim, C.

doi:10.1111/bjd.16677

Cited by 69 publications

(55 citation statements)

References 9 publications

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“…16,17 A similar ex vivo study using MSOT has been performed on other malignancies (eg, melanoma) for better selection of the excision margins. 18 However, to the authors' knowledge, there has been no ex vivo study conducted to date that uses MSOT in the assessment of breast tumor margins after lumpectomy. Hence, we would like to present the first case of breast tumor margin assessment using MSOT in a 55-year-old patient who underwent lumpectomy for IDC.…”

Section: Clinical Practice Pointsmentioning

confidence: 99%

Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study

Goh

Balasundaram

Moothanchery

et al. 2018

Clinical Breast Cancer

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Section: Clinical Practice Pointsmentioning

confidence: 99%

Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study

Goh

Balasundaram

Moothanchery

et al. 2018

Clinical Breast Cancer

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“…The handheld probes implementation of PAI systems are necessary to access these contoured areas. Various PAI configurations with handheld transducer setup have been reported to quantify the size of these in situ lesions [24–28] and ex vivo specimens [29], which were substantiated with histological measurements of the lesion after it has been excised for the former.…”

Section: Photoacoustic Imagingmentioning

confidence: 98%

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress

Attia

Dev

et al. 2020

Transl Biophotonics

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Dermatologists mainly entrust visual clinical examinations in conjunction with histopathology for an informed skin condition diagnosis, which is invasive and not adequate to assess skin conditions still present in subcutaneous skin layers. With emerging complementary imaging and spectroscopic technologies currently available, the assessment of skin conditions is more accessible than before. This review article will cover these technologies including: photoacoustic imaging, reflectance confocal microscopy, multiphoton microscopy, optical coherence tomography and confocal Raman spectroscopy. The basic concepts of these technologies and their configurations will be touched on, together with their limitations and future directions. The review article will discuss how these technologies are utilized for cutaneous applications, examining studies accomplished either in vivo on humans or on ex vivo human specimens.

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“…Photoacoustic tomography (PAT), an imaging modality with high-resolution, optical contrast and deep penetration [1], has potential applications in clinical practices such as breast [2][3][4], dermatologic [5][6][7][8][9], and vascular imaging [10][11][12]. In PAT systems, short laser pulses illuminate biological tissue to excite photoacoustic (PA) signals.…”

Section: Introductionmentioning

confidence: 99%

Photothermally tunable Fabry-Pérot fiber interferometer for photoacoustic mesoscopy

Chen

2020

Biomed. Opt. Express

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An optical fiber based Fabry-Pérot interferometer whose resonant wavelength can be dynamically tuned was designed and realized for photoacoustic mesoscopy. The optical path length (OPL) of the Fabry-Pérot cavity can be modulated by a photothermal heating process, which was achieved by adjusting the power of a 650 nm heating laser. The optical heating process can effectively change the thickness and refractive index of the polymer spacer of the sensor cavity. The robustness of the sensor can be greatly improved by proper packaging. The interferometer was interrogated by a relatively cheap wavelength-fixed 1550 nm laser for broadband and sensitive ultrasound detection, eliminating the requirement for an expensive tunable interrogation laser. The sensing module was then integrated into a photoacoustic mesoscopic imaging system. Two phantom imaging experiments and an ex vivo imaging experiment demonstrated the capability of such a miniature sensor. The interferometer has an acoustic detection bandwidth of up to 30 MHz and a noise equivalent pressure of 40 mPa/Hz 1/2 (i.e., 220 Pa over the full detection bandwidth). The new tuning mechanism and the batch-production compatibility of the sensor holds promises for commercialization and parallelized detection.

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Multispectral ex vivo photoacoustic imaging of cutaneous melanoma for better selection of the excision margin

Cited by 69 publications

References 9 publications

Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study

Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress

Photothermally tunable Fabry-Pérot fiber interferometer for photoacoustic mesoscopy

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