Noninvasive Characterization of Myocardial Molecular Interventions by Integrated Positron Emission Tomography and Computed Tomography

Wagner, Bettina; Anton, Martina; Nekolla, Stephan G.; Reder, Sybille; Henke, Julia; Seidl, Stefan; Hegenloh, Renate; Miyagawa, Masao; Haubner, Roland; Schwaiger, Markus; Bengel, Frank M.

doi:10.1016/j.jacc.2006.08.029

Cited by 37 publications

(20 citation statements)

References 19 publications

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“…In clinical practice, the fusion images are typically used to map or localize the abnormal territory on emission images to the diseased vessel on coronary CTA (121). For research applications, hybrid imaging of radionuclide and CTA images is obtained for localization of radionuclide uptake (122,123). The fused images can be helpful to localize diseased regions but should not be the sole images used for diagnostic interpretation.…”

Section: Ctac and Emission Imagesmentioning

confidence: 99%

SNMMI/ASNC/SCCT Guideline for Cardiac SPECT/CT and PET/CT 1.0

et al. 2013

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Section: Ctac and Emission Imagesmentioning

confidence: 99%

SNMMI/ASNC/SCCT Guideline for Cardiac SPECT/CT and PET/CT 1.0

et al. 2013

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“…9,10 Only a few reports are available that describe molecular imaging of cardiac angiogenesis with nuclear 11,12 or optical 13 imaging.…”

mentioning

confidence: 99%

Molecular Magnetic Resonance Imaging of Myocardial Angiogenesis After Acute Myocardial Infarction

et al. 2010

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Background-Angiogenesis is a natural mechanism to restore perfusion to the ischemic myocardium after acute myocardial infarction (MI). Therapeutic angiogenesis is being explored as a novel treatment for MI patients; however, sensitive, noninvasive in vivo measures of therapeutic efficacy are lacking and need to be developed. Here, a molecular magnetic resonance imaging method is presented to noninvasively image angiogenic activity in vivo in a murine model of MI with cyclic Asn-Gly-Arg (cNGR)-labeled paramagnetic quantum dots (pQDs). The tripeptide cNGR homes specifically to CD13, an aminopeptidase that is strongly upregulated during myocardial angiogenesis. Methods and Results-Acute MI was induced in male Swiss mice via permanent ligation of the left anterior descending coronary artery. Molecular magnetic resonance imaging was performed 7 days after surgery and up to 2 hours after intravenous contrast agent administration. Injection of cNGR-pQDs resulted in a strong negative contrast that was located mainly in the infarcted myocardium. This negative contrast was significantly less in MI mice injected with unlabeled pQDs and in sham-operated mice injected with cNGR-pQDs. Validation with ex vivo 2-photon laser scanning microscopy revealed a strong colocalization of cNGR-pQDs with vascular endothelial cells, whereas unlabeled pQDs were mostly extravasated and diffused through the tissue. Additionally, 2-photon laser scanning microscopy demonstrated significant microvascular remodeling in the infarct/border zones compared with remote myocardium. Conclusions-cNGR-pQDs allow selective, noninvasive detection of angiogenic activity in the infarcted heart with the use of in vivo molecular magnetic resonance imaging and ex vivo 2-photon laser scanning microscopy. (Circulation. 2010; 121:775-783.)

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“…This type of reporter gene technology was used to detect the expression of VEGF 121 with PET/CT in porcine myocardium after adenoviral transfer (11). In that study, the authors demonstrated the value of integrated multimodal systems for detecting VEGF overexpression (with PET) and for localizing uptake to the myocardium (with CT).…”

Section: Nuclear Approachesmentioning

confidence: 99%