Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart

Han, Chengzong; Pogwizd, Steven M.; Killingsworth, Cheryl R.; Zhou, Zhaoye; He, Bin

doi:10.1016/j.hrthm.2013.06.010

Cited by 24 publications

(22 citation statements)

References 34 publications

(42 reference statements)

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“…The CEI technique was previously used to reconstruct 3-D ventricular cardiac activation patterns from BSPM, and has been validated with animal studies [11–13, 24, 25]. In the present study, CEI was used to image atrial electrical activity.…”

Section: Methodsmentioning

confidence: 94%

Noninvasive Imaging of High-Frequency Drivers and Reconstruction of Global Dominant Frequency Maps in Patients With Paroxysmal and Persistent Atrial Fibrillation

Zhou

Chen

et al. 2016

IEEE Trans. Biomed. Eng.

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Objective Highest dominant-frequency (DF) drivers maintaining atrial fibrillation (AF) activities are effective ablation targets for restoring sinus rhythms in patients. This study aims to investigate whether AF drivers with highest activation rate can be noninvasively localized by means of a frequency-based cardiac electrical imaging (CEI) technique, which may aid in the planning of ablation strategy and the investigation of the underlying mechanisms of AF. Method A total of 7 out of 13 patients were recorded with spontaneous paroxysmal or persistent AF and analyzed. The bi-atrial DF maps were reconstructed by coupling 5-second BSPM with CT-determined patient geometry. The CEI results were compared with ablation sites and DFs found from BSPMs. Results CEI imaged left-to-right maximal frequency gradient (7.42 ± 0.66 Hz vs. 5.85 ± 1.2 Hz, LA vs. RA, p<0.05) in paroxysmal AF patients. Patients with persistent AF were imaged with a loss of the intra-chamber frequency gradient and a dispersion of the fast sources in both chambers. CEI was able to capture the AF behaviors, which were characterized by short-term stability, dynamic transition, and spatial repetition of the highest DF sites. The imaged highest DF sites were consistent with ablation sites in patients studied. Conclusions The frequency-based CEI allows localization of AF drivers with highest DF and characterization of the spatiotemporal frequency behaviors, suggesting the possibility for individualizing treatment strategy and advancing understanding of the underlying AF mechanisms. Significance: The establishment of noninvasive imaging techniques localizing AF drivers would facilitate management of this significant cardiac arrhythmia.

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Section: Methodsmentioning

confidence: 94%

Noninvasive Imaging of High-Frequency Drivers and Reconstruction of Global Dominant Frequency Maps in Patients With Paroxysmal and Persistent Atrial Fibrillation

Zhou

Chen

et al. 2016

IEEE Trans. Biomed. Eng.

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“…The Weighted Minimum Norm (WMN) method has been used in the previous 3D cardiac electric imaging studies and has shown to have a generally good performance in imaging accuracy among the minimum norm based methods [9], [28], [29]. Therefore, in this study we evaluated the performance of the proposed CESI method as compared with the WMN method.…”

Section: Methodsmentioning

confidence: 99%

Temporal Sparse Promoting Three Dimensional Imaging of Cardiac Activation

Zhou

2015

IEEE Trans. Med. Imaging

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A new Cardiac Electrical Sparse Imaging (CESI) technique is proposed to image cardiac activation throughout the three-dimensional myocardium from body surface electrocardiogram (ECG) with the aid of individualized heart-torso geometry. The sparse property of cardiac electrical activity in the time domain is utilized in the temporal sparse promoting inverse solution, one formulated to achieve higher spatial-temporal resolution, stronger robustness and thus enhanced capability in imaging cardiac electrical activity. Computer simulations were carried out to evaluate the performance of this imaging method under various circumstances. A total of 12 single site pacing and 7 dual sites pacing simulations with artificial and the hospital recorded sensor noise were used to evaluate the accuracy and stability of the proposed method. Simulations with modeling error on heart-torso geometry and electrode-torso registration were also performed to evaluate the robustness of the technique. In addition to the computer simulations, the CESI algorithm was further evaluated using experimental data in an animal model where the noninvasively imaged activation sequences were compared with those measured with simultaneous intracardiac mapping. All of the CESI results were compared with conventional weighted minimum norm solutions. The present results show that CESI can image with better accuracy, stability and stronger robustness in both simulated and experimental circumstances. In sum, we have proposed a novel method for cardiac activation imaging, and our results suggest that the CESI has enhanced performance, and offers the potential to image the cardiac activation and to assist in the clinical management of ventricular arrhythmias.

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“…Simultaneous recordings of torso and transmural ventricular potentials have also been obtained in rabbits and dogs, with geometries obtained by ultrafast CT several days before experiments. 79,80 Using these data, the accuracy of several different activation time-based inverse algorithms has been assessed in normal hearts 80,81 and during norepinephrine-induced focal VT. 25,79 More recently, this group has also used pig models. 82,83 Cardiac potentials were recorded on the endocardial surface only, whereas cardiac and torso geometries reconstructed initially using the endocardial mapping system were subsequently fused with MR images of the torso.…”

Section: Validation Studiesmentioning

confidence: 99%