Introduction to Noninvasive Cardiac Mapping

Bear, Laura; Cuculich, Phillip S.; Bernus, Olivier; Efimov, Igor R.; Dubois, Rémi

doi:10.1016/j.ccep.2014.11.015

Cited by 15 publications

(15 citation statements)

References 86 publications

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“…Considering computational cost, most inverse problems in cardiac imaging consider simplifications in the forward model, as reviewed in the literature. [15][16][17] Recently, patient-specific heart meshes and monodomain forward models have been studied with manual selection of optimal parameters. 40 In addition, adjoint-based PDE-constrained optimization for the monodomain/bidomain models is developing, 20,21,23 but the number of large scale (3D) studies is still very limited with the notable exception.…”

Section: Discussionmentioning

confidence: 99%

Inverse estimation of cardiac activation times via gradient‐based optimization

Kallhovd

Maleckar

Rognes

2017

Numer Methods Biomed Eng

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Computational modeling may provide a quantitative framework for integrating multiscale data to gain insight into mechanisms of heart disease, identify and test pharmacological and electrical therapy and interventions, and support clinical decisions. Patient-specific computational cardiac models can help guide such procedures, and cardiac inverse modeling is a promising alternative to adequately personalize these models. Indeed, full cardiac inverse modeling is currently becoming computationally feasible; however, fundamental work to assess the feasibility of emerging techniques is still needed. In this study, we use a partial differential equation-constrained optimal control approach to numerically investigate the identifiability of an initial activation sequence from synthetic (partial) observations of the extracellular potential using the bidomain approximation and 2D representations of cardiac tissue. Our results demonstrate that activation times and duration of several stimuli can be recovered even with high levels of noise, that it is sufficient to sample the observations at the electrocardiogram-relevant sampling frequency of 1 kHz, and that spatial resolutions that are coarser than the standard in electrophysiological simulations can be used. The optimization of activation times is still effective when synthetic data are generated with a different cell membrane kinetics model than optimized for. The findings thus indicate that the presented approach has potential for finding activation sequences from clinical data modalities, as an extension to existing cardiac imaging approaches.

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Section: Discussionmentioning

confidence: 99%

Inverse estimation of cardiac activation times via gradient‐based optimization

Kallhovd

Maleckar

Rognes

2017

Numer Methods Biomed Eng

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“…The combination of these three systems resulted in a 12-lead ECG, which became one of the standard non-invasive diagnostic tools in the medical fiel [6]. Electrocardiographic findings, such as ST segment depressions, inverted T waves, and pathological Q waves are some of the ECG uses for diagnosis of ischemia [7,8].…”

Section: International Journal Of Cardiovascular Practicementioning

confidence: 99%

The Association between Myocardial Perfusion Scan and Electrocardiographic Findings among Patients with Myocardial Ischemia

Farahani

Skandari

Abbasi

et al. 2017

ijcp

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Introduction: The aim of this study was to determine the consistency of Electrocardiography (ECG) and myocardial perfusion scan findings of patients with myocardial ischemia at Firoozgar and Hazrat-Rasool hospitals. Methods: Electrocardiogram of 80 patients undergoing myocardial perfusion scans was analyzed. All patients had a stable angina. All patients with bundle branch blocks and history of MI and coronary bypass or angiography were excluded. Overall, 120 patients were evaluated with single photon emission tomography/myocardial perfusion imaging for ischemia and 80 patients had a positive test. Results: Forty-five percent of patients were female and 55% were male. The average age of patients was 61.48 years. Sixty-one patients (76.25%) had normal ECG and 19 patients (23.75) had pathological changes in their ECG. Eleven patients had ST segment depression and 6 patients had T wave inversion. Furthermore, 21 patients (26.25%) had lateral wall ischemia in their myocardial perfusion scan and 13 (16.25%) patients had septal wall ischemia. The ECG changes in male patients and hypertensive cases were more prominent. Conclusions: This study showed that ST-T changes (ST depression and T inversion) in the ECG are more suggestive of accuracy of myocardial ischemia and ECG.

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“…High density body surface potential mapping (BSPM) provides precise detection and diagnosis of electrophysiological phenomena, either through direct analysis of BSPM [1] or through non-invasive electrocardiographic imaging of cardiac electrical activity [2]. Clinicians prefer to interpret this information in light of a 12-lead ECG, which is of daily use in cardiac arrhythmia diagnosis.…”

Section: Introductionmentioning

confidence: 99%